Cleveland Guardians vs Kansas City Royals Prediction, 9/25/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Kansas City Royals

Date: Friday, September 25, 2026

Location: Kauffman Stadium in Kansas City, MO

TV: MLB.TV

Odds/Point Spread: Cleveland (-130) Kansas City (+110)

The Kansas City Royals (67-90) will try to defeat the Cleveland Guardians (82-75) at Kauffman Stadium on Friday. The odds on this game have the Guardians at -130 and the Royals are at +110. The total is 9. The pitchers taking the mound are Gavin Williams and Noah Cameron.

Cleveland has a slugging % of .377 and have struck out 1,242 times, while drawing a walk on 552 occasions. They have accrued 624 runs batted in and 1,250 base knocks this year, while their team batting average sits at .239. The Guardians have accounted for 243 two-baggers as a unit and have smacked 152 baseballs out of the stadium. They have tallied 652 runs while having a team on-base percentage of .316. As a team, the Cleveland Guardians are notching 4.2 runs per game, which is 26th in the league.

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They have accrued a K/BB ratio of 2.88 and their pitching staff has earned a collective WHIP of 1.26. Guardians pitchers have yielded 170 home runs and also 649 runs in total (8th in the league). Cleveland has given up 1,240 base knocks (8.0 per 9 innings) in addition to 584 earned runs. The Guardians have an ERA of 3.77 this season (8th in the league), and the staff has struck out 1,488 batters. They have walked 517 opposing batters and their FIP is 3.82 as a squad on the season.

Guardians pitchers have entered the contest with runners on base 163 times as well as having 171 appearances in high leverage situations. The relievers have racked up 111 holds on the campaign (2nd in MLB). The Guardians relievers have earned a save percentage of 72.6% and have stepped onto the mound in 175 save situations. They have compiled 45 saves this season and have blown 17 out of their 62 save chances. The bullpen pitchers have inherited 258 base runners so far this season with 28.3% of those runners earned a run for their team. The Guardians have dispatched 537 relievers to the hill this year.

The Cleveland Guardians have accounted for 4,184 putouts this season, as well as 1,220 assists and 81 errors. Their fielding percentage is at .985 which puts them in 17th in professional baseball, and they have turned 102 double plays. The Guardians have converted 69.3% of balls in play into outs out of 12,552 innings on the diamond, ranking them 21st in the majors.

Williams has taken the hill for 506 innings and has tallied 577 punch outs so far in his MLB career. His ERA is 3.57 (201 ER's allowed) and his career WHIP is 1.217. He has surrendered 407 base hits (7.2 hits per nine innings) and has had 209 free passes. Williams (32-28 career record) has a FIP of 3.52 while he has faced 2,109 batters during his time in the major leagues.

Kansas City has accumulated 164 home runs on the campaign to go along with 635 runs batted in. They have put up 280 doubles, while walking 500 times as well as racking up 667 runs. The Kansas City Royals have earned a team on-base percentage of .315 as well as a batting average of .246 on the season. The Royals hold a slugging percentage of .399 and they average 4.25 runs per game (23rd in the league). They have struck out on 1,235 occasions (26th in baseball) and have tallied 1,294 base hits.

The Royals have a WHIP of 1.398 and are the owners of a FIP of 4.69 as a unit for the year. They are sitting at 28th in the league as a staff in total hits conceded with 1,371. The Kansas City pitching staff have surrendered 772 runs this season while holding an ERA of 4.72 (724 earned runs yielded). Their K/BB ratio is 7.50 (1,142 strikeouts against 557 free passes). They have allowed 200 homers and they yield 5.04 runs per 9 innings (26th in baseball).

Sitting with 147 save situations, the Royals have 82 holds in addition to 26 blown saves. Kansas City has had bullpen pitchers take the mound in 62 save opportunities and they have walked away with 36 saves. Kansas City relief pitchers have an inherited score rate of 39.0% of 164 inherited runners. Their relievers have stepped onto the hill 157 times in high leverage situations and also on 113 occasions with runners on. They are ranked 21st in MLB holding a save rate of 58.1%, and they have dispatched 512 relievers onto the field this year.

Out of their 12,414 innings played, the Royals hold a defensive efficiency of 69.6% (16th in professional baseball). The Kansas City Royals have turned 138 double plays and own a fielding percentage of .987 (7th in baseball). The Royals have 1,418 assists, 71 errors and have notched a total of 4,138 putouts so far this year.

So far in his MLB career, Cameron has given up 262 hits and he has 269 punch outs in 310 innings pitched. Cameron (18-15 career record) has a 3.51 ERA while giving up 7.6 hits per 9 innings. He has allowed 121 ER's while earning a WHIP of 1.157 and being the owner of a FIP of 3.5. His strikeout to walk ratio is 2.77 and he has faced 1,274 opposing hitters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Kansas City (+110)

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