Cleveland Guardians vs St. Louis Cardinals Prediction, 4/13/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs St. Louis Cardinals

Date: Monday, April 13, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Cleveland (+125) St. Louis (-145)

The St. Louis Cardinals (8-5) will try to defeat the Cleveland Guardians (8-6) at Busch Stadium on Monday. The moneyline on this game has the Guardians at +125 while the Cardinals are priced at -145. The total comes in at 8. The expected starting pitchers will be Gavin Williams and Matthew Liberatore.

Cleveland has a slugging % of .365 and have been called out on strikes 111 times, while drawing a walk on 50 occasions. They have 48 RBI's and 98 base knocks on the season, and their average at the plate sits at .220. The Guardians have tallied 26 doubles as a team and have knocked 13 balls out of the stadium. They have earned 51 runs scored and hold an OBP of .309. As a team, the Cleveland Guardians are compiling 3.6 runs/g, which ranks them 23rd in the league.

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The Guardians hold a team ERA of 3.66 on the year (11th in the league), and the staff has rung up 146 hitters. Guardians pitchers have relinquished 19 home runs in addition to 54 runs (11th in the league). Their pitching staff has walked 53 opposing hitters and their FIP is 4.19 as a squad so far this year. Cleveland has given up 97 hits (7.1 per 9 innings) and 50 earned runs. They have accumulated a K/BB ratio of 2.75 and the pitching staff has recorded a WHIP of 1.22.

The Guardians have dispatched 46 relief pitchers to the hill for the year. The bullpen pitchers have inherited 18 base runners for the year with 5.6% of those runners crossing home plate. The bullpen have 9 holds for the year (9th in the league). Guardians relief pitchers have come into the game with runners on 12 times and also have had 17 appearances in high leverage situations. They have recorded 5 saves on the campaign and have missed out on 1 of their 6 save chances. The Guardians bullpen have a save percentage of 83.3% and stepped onto the hill in 15 save situations.

The Cincinnati Reds are sitting with 369 putouts on the year, in addition to 94 assists and 4 errors. Their fielding rate is currently at .991 which has them ranked 5th in MLB, and have earned 12 double plays. The Guardians have converted 72.2% of balls hit into play into outs out of their 1,107 innings, which has them sitting 5th in MLB.

Williams has thrown 342 frames and has 358 punch outs during his MLB career. His earned run average is 3.47 (132 earned runs allowed) and he has a career WHIP of 1.282. He has conceded 273 base knocks (7.2 hits per 9 innings) and has had 166 free passes. Williams (19-21 career record) has earned a FIP of 3.42 while he has faced 1,448 hitters during his time in the majors.

The St. Louis Cardinals have accumulated an on-base percentage of .329 in addition to a team batting average of .228 for the year. They have struck out on 108 occasions (23rd in baseball) and have notched a total of 98 base knocks. St. Louis has 13 HRs this season to go along with 61 RBIs. The Cardinals have a slugging percentage of .359 and they score 4.77 runs per game (7th in MLB). They have 17 doubles, while getting a free base 59 times as well as putting up 62 runs.

The St. Louis pitching staff have surrendered 64 runs so far this season while having an ERA of 4.65 (61 earned runs yielded). They have given up 13 homers and they surrender 4.88 runs per 9 innings (25th in baseball). The Cardinals hold a team WHIP of 1.449 with a FIP of 4.70 as a unit so far this year. They currently have a strikeout to walk ratio of 6.20 (81 strikeouts vs 53 walks). They are currently ranked 26th in baseball as a pitching staff in total hits relinquished with 118.

Sitting with 21 save situations, the Cardinals have recorded 13 holds in addition to 2 blown saves. St. Louis has called on relief pitchers to enter the contest in 7 save opportunities and they have tallied 5 saves. St. Louis bullpen pitchers have an inherited score rate of 42.3% out of 26 inherited runners. Their relief pitchers have stepped onto the hill 21 times in high leverage situations and on 17 occasions with runners on base. They rank 14th in MLB with a save percentage of 71.4%, and they have sent 50 relief pitchers to the mound so far this year.

In their 1,062 innings played, the Cardinals are sitting with a efficiency on defense of 70.2% (15th in baseball). The St. Louis Cardinals have gotten 9 double plays and hold a fielding percentage of .986 (15th in pro baseball). The Cardinals have accrued 131 assists, 7 errors and have earned a total of 354 putouts this season.

In his pro baseball career, Liberatore has surrendered 366 hits while tallying 282 punch outs in 350 frames. He has allowed 178 earned runs while earning a WHIP of 1.377 and a FIP of 4.5. He has a strikeout to walk ratio of 2.43 and he has gone up against 1,513 batters thus far in his career. Liberatore (16-24 career mark) has a 4.58 ERA while allowing 9.4 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (-145)

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