Cleveland Guardians vs St. Louis Cardinals Prediction, 4/14/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs St. Louis Cardinals

Date: Tuesday, April 14, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Cleveland (-210) St. Louis (+172)

The Cleveland Guardians (9-7) are traveling to Busch Stadium on Tuesday where they will go up against the St. Louis Cardinals (8-7). The moneyline on this matchup has Cleveland at -210 while St. Louis is opening at +172. The over/under comes in at 9. The starting pitchers will be Joey Cantillo and Michael McGreevy.

As a unit, the Cleveland Guardians are knocking in 3.6 runs per game, which is 25th in MLB. They have accumulated 58 runs while holding a team OBP of .311. The Guardians have tallied 31 two-baggers as a unit and have hit 15 baseballs out of the stadium. They have 54 runs batted in as well as 114 hits for the year, while their batting average is .222. Cleveland has a slugging percentage of .370 and have been called out on strikes 123 times, while being walked on 59 occasions.

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The Guardians have a team earned run average of 4.05 for the year (18th in the league), and the staff has rung up 160 batters. Guardians pitchers have allowed 20 home runs and 67 runs (16th in MLB). Their pitching staff has walked 58 hitters and their FIP comes in at 4.09 as a team for the season. Cleveland has given up 121 hits (7.8 per 9 innings) in addition to 63 earned runs. Their K/BB ratio is 2.76 and the pitching staff has earned a collective WHIP of 1.28.

The Guardians have sent 51 relief pitchers to the hill for the season. The relief pitchers have inherited 23 runners this year with 13.0% of them crossing the plate. The bullpen have tallied 11 holds so far this season (10th in baseball). Guardians relief pitchers have entered the game with runners on base 15 times as well as having 17 appearances in high leverage situations. They have accumulated 5 saves for the year and have blown 1 of their 6 save opportunities. The Guardians bullpen have earned a save percentage of 83.3% and have come into the game in 17 save situations.

The Guardians have transformed 69.9% of balls in play into outs in their 1,260 innings on the field, which has them sitting 18th in baseball. The Cincinnati Reds have earned 420 putouts so far this season, as well as 113 assists and 5 errors. Their fielding percentage is holding steady at .991 which has them ranked 2nd in baseball, and they have turned 13 double plays.

Cantillo has thrown 148 innings and has tallied 172 punch outs thus far in his career. Cantillo (8-7 win-loss mark in his career) has earned a FIP of 3.53 while he has faced 624 batters during his time in the majors. His earned run average is 3.58 (59 earned runs allowed) and his WHIP is 1.269. He has conceded 124 base knocks (7.5 hits per 9 innings) and has 64 walks.

The St. Louis Cardinals have an OBP of .320 in addition to a batting average of .224 this season. They have struck out on 120 occasions (25th in baseball) and are sitting with 110 base hits. St. Louis has accumulated 16 HRs over the course of the season to go along with 65 RBIs. The Cardinals hold a team slugging % of .356 and they earn 4.40 runs per game (12th in MLB). They have notched 17 two-baggers, while getting a free base 64 times as well as recording 66 runs.

The Cardinals have a team WHIP of 1.478 and have a FIP of 4.71 as a squad for the year. They have earned a strikeout to walk ratio of 6.00 (91 strikeouts vs 61 free passes). They are sitting at 30th in baseball as a pitching staff in total hits conceded with 140. They have relinquished 14 home runs and they relinquish 5.29 runs per 9 innings (26th in baseball). The St. Louis pitching staff have surrendered 80 runs this season while holding a team ERA of 5.10 (77 earned runs conceded).

St. Louis relievers hold an inherited score percentage of 35.5% out of their 31 inherited base runners. Their relievers have come in 22 times in high leverage situations and on 19 occasions with runners on base. With 21 save situations, the Cardinals have compiled 13 holds and 2 blown saves. They are ranked 14th in the league with a save percentage of 71.4%, and they have dispatched 56 bullpen pitchers to the mound over the course of the season.

In 1,224 innings played, the Cardinals have accumulated a efficiency on defense of 69.6% (20th in the majors). The St. Louis Cardinals have gotten 12 double plays and have a fielding percentage of .988 (10th in professional baseball). The Cardinals have racked up 150 assists, 7 errors and have 408 putouts for the season.

McGreevy (12-5 record in his career) has a 3.75 ERA while surrendering 8.5 hits per 9 innings. He has a K/BB ratio of 3.58 and he has gone up against 548 batters so far in his career. He has conceded 56 ER's while earning a WHIP of 1.124 and being the owner of a FIP of 3.7. In his pro baseball career, McGreevy has surrendered 127 base knocks while earning 86 strikeouts in 134 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cleveland (-210)

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