Detroit Tigers vs Baltimore Orioles Prediction, 5/22/2026 MLB Picks, Best Bets & Odds

Game: Detroit Tigers vs Baltimore Orioles

Date: Friday, May 22, 2026

Location: Oriole Park at Camden Yards in Baltimore, MD

TV: MASN

Odds/Point Spread: Detroit (-130) Baltimore (+110)

Oriole Park at Camden Yards is where the Baltimore Orioles (21-29) will compete against the Detroit Tigers (20-30) on Friday. The line on this contest has the Tigers at -130 while the Orioles are at +110. The over/under is set at 9. The expected starting pitchers are Jack Flaherty and Chris Bassitt.

The Tigers have earned 85 doubles as a team and have smacked 43 balls out of the park. Detroit is slugging .373 and have been called out on strikes 428 times, while being walked on 189 occasions. As a team, the Detroit Tigers are compiling 3.9 runs per game, which ranks them 27th in the league. They have amassed 184 runs batted in in addition to 391 base knocks for the season, and their average at the plate sits at .236. They have tallied 195 runs while holding a team OBP of .319.

Get all of our MLB Betting Picks

The Tigers have an ERA of 3.98 over the course of the season (13th in MLB), and the staff has rung up 403 batters. Tigers pitchers have surrendered 43 home runs in addition to 216 runs in total (12th in baseball). Their pitching staff has walked 173 opposing batters and their FIP is 3.84 as a unit so far this year. Detroit has conceded 391 hits (8.1 per 9 innings) as well as 193 earned runs. They have earned a strikeout to walk ratio of 2.33 and the pitching staff holds a WHIP of 1.29.

The Tigers have sent 157 relief pitchers to the mound so far this season. The bullpen pitchers have inherited 98 base runners so far this season and 33.7% of those players ended up crossing the plate. The relief pitchers have tallied 18 holds on the campaign (25th in MLB). Tigers relief pitchers have stepped onto the hill with players on base 62 times as well as having 46 appearances in high leverage situations. They have tallied 9 saves on the year and have not converted 11 of 20 chances to save the game. The Tigers relievers have earned a save rate of 45.0% and have stepped onto the mound in 39 save situations.

The Tigers have converted 70.0% of balls hit into play into outs out of their 3,927 innings, which has them sitting at 17th in pro baseball. The Detroit Tigers have a tally of 1,309 putouts thus far, as well as 433 assists and 27 errors. Their fielding percentage is holding at .985 which ranks 22nd in baseball, and have accumulated 44 double plays.

Flaherty has taken the hill for 1,033 frames and has earned 1,178 strikeouts during his MLB career. His earned run average is 3.88 (446 earned runs allowed) and he has a WHIP of 1.216. He has allowed 877 base knocks (7.6 hits per 9 innings) with 380 free passes. Flaherty (63-61 career record) is the owner of a FIP of 3.83 while he has faced 4,326 opposing batters during his time in the majors.

Baltimore has knocked in 54 home runs on the campaign to go along with 212 RBIs. They have recorded 84 doubles, while walking 190 times and notching 215 runs. The Baltimore Orioles are sitting with an on-base percentage of .314 as well as a batting average of .233 for the year. The Orioles hold a slugging percentage of .386 and they average 4.30 runs per contest (17th in the league). They have struck out on 464 occasions (3rd in the league) and are sitting with 386 base knocks.

The Orioles hold a team WHIP of 1.463 with a FIP of 4.47 as a staff on the campaign. Their strikeout to walk ratio comes in at 8.30 (406 strikeouts against 191 free passes). They sit at 27th in baseball as a pitching staff in total hits conceded with 450. They have given up 60 home runs and they yield 5.63 runs per 9 innings (29th in MLB). The Baltimore pitching staff have conceded 274 runs on the campaign while holding an ERA of 4.97 (242 earned runs yielded).

Sitting with 47 save situations, the Orioles have earned 28 holds and 5 blown saves. Baltimore has called on bullpen pitchers to step onto the hill in 18 save opportunities and they have converted 13 saves. Baltimore relief pitchers hold an inherited score percentage of 22.2% out of 63 inherited runners. Their relief pitchers have stepped onto the mound 48 times in high leverage situations and on 44 occasions with runners on. They rank 6th in MLB with a save rate of 72.2%, and they have sent 172 relievers to the mound this season.

The Baltimore Orioles have gotten 40 double plays and have a fielding rate of .984 (25th in the majors). The Orioles have 417 assists, 29 errors and have earned 1,315 putouts so far this season. Out of their 3,945 innings on the diamond, the Orioles hold a defensive efficiency of 67.6% (29th in pro baseball).

So far in his career, Bassitt has surrendered 1,238 hits while he has tallied 1,221 punch outs in 1,321 innings. He has conceded a total of 543 ER's while holding a WHIP of 1.261 and a FIP of 3.6. His strikeout to walk ratio is 2.85 and he has faced 5,612 batters so far in his MLB career. Bassitt (86-68 record in his career) holds a 3.70 earned run average while allowing 8.4 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Baltimore (+110)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.