Houston Astros vs Baltimore Orioles Prediction, 4/29/2026 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Baltimore Orioles

Date: Wednesday, April 29, 2026

Location: Oriole Park at Camden Yards in Baltimore, MD

TV: MASN

Odds/Point Spread: Houston (+110) Baltimore (-132)

The Houston Astros (11-18) are en route to Oriole Park at Camden Yards on Wednesday where they will meet the Baltimore Orioles (13-15). The odds on this game have Houston at +110 and Baltimore is opening at -132. The over/under is 8. The pitchers expected to start will be Peter Lambert and Chris Bassitt.

As a unit, the Houston Astros are notching 5.2 runs per outing, which puts them at 5th in MLB. They have tallied 151 runs and have an on-base percentage of .345. The Astros have tallied 63 doubles as a unit and have knocked 37 balls out of the park. They have accumulated 143 runs batted in and 254 base knocks on the campaign, and their team batting average is .259. Houston has a slugging rate of .438 and have struck out 221 times, while being walked on 120 occasions.

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The Astros hold a team ERA of 5.97 so far this year (30th in baseball), and they have struck out 266 hitters. Astros pitchers have allowed 43 home runs in addition to 174 runs in total (30th in MLB). Their pitching staff has walked 158 batters and their FIP comes in at 5.36 as a unit this season. Houston has surrendered 260 base hits (9.2 per 9 innings) and also 168 earned runs. They have earned a K/BB ratio of 1.68 and their pitching staff holds a collective WHIP of 1.65.

The Astros relief pitchers have a save percentage of 85.7% and have entered the game in 19 save situations. They have accumulated 6 saves for the year and have blown 1 of their 7 chances to save the game. The relievers have inherited 63 runners this season and 30.2% of them earned a run for their team. Astros relief pitchers have gone to the mound with runners on base 37 times in addition to having 23 appearances in high leverage situations. The Astros have sent 94 relief pitchers to the hill so far this year. The bullpen have a total of 12 holds for the year (26th in MLB).

The Astros have turned 67.0% of balls hit into play into outs in their 2,280 innings on the field, which ranks them 29th in professional baseball. The Houston Astros have notched a total of 760 putouts at this point in the season, as well as 217 assists and 10 errors. Their fielding percentage is currently at .990 which has them sitting 5th in MLB, and have earned 30 double plays.

Lambert (9-20 career win-loss mark) has a FIP of 6.07 while going up against 1,153 hitters in the major leagues. He has allowed 307 base hits (10.9 hits per nine innings) and has had 99 free passes. His ERA is 6.16 (174 earned runs allowed) and he has a career WHIP of 1.597. Lambert has taken the hill for 254 frames and is sitting with 197 strikeouts so far in his MLB career.

The Baltimore Orioles have accumulated an OBP of .321 in addition to a team batting average of .238 so far this season. They have struck out on 257 occasions (9th in baseball) and are sitting with 223 base knocks. Baltimore is sitting with 34 long balls on the season and 124 RBIs. The Orioles have a team slugging % of .400 and they are scoring 4.46 runs per outing (17th in MLB). They have 47 doubles, while walking 109 times as well as racking up 125 runs.

The Orioles hold a team WHIP of 1.396 and are the owners of a FIP of 4.26 as a unit on the season. They come in at 24th in MLB as a pitching staff in total hits allowed with 248. The Baltimore pitching staff have given up 140 runs on the season and come in with a team ERA of 4.33 (120 earned runs relinquished). Their strikeout to walk ratio is 8.70 (240 strikeouts against 100 free passes). They have surrendered 33 homers and they relinquish 5.06 runs per 9 innings (24th in MLB).

Baltimore bullpen pitchers have an inherited score percentage of 14.7% out of 34 inherited base runners. Their bullpen pitchers have come in 35 times in high leverage situations in addition to 25 occasions with runners on base. Sitting with 30 save situations, the Orioles have accumulated 17 holds and 3 blown saves. They rank 4th in the league holding a save percentage of 75.0%, and they have dispatched 96 bullpen pitchers to the hill for the season.

Out of their 2,247 innings on the field, the Orioles have earned a defensive efficiency of 67.7% (27th in professional baseball). The Baltimore Orioles have turned 24 double plays and have notched a fielding percentage of .982 (24th in professional baseball). The Orioles have racked up 247 assists, 18 errors and have amassed 749 putouts so far this year.

Bassitt (84-67 career mark) has earned a 3.69 ERA and has surrendered 8.4 hits per 9 innings. He has a K/BB ratio of 2.85 and he has gone up against 5,518 opposing batters during his MLB career. He has conceded 533 earned runs while earning a WHIP of 1.260 and being the owner of a FIP of 3.6. In his MLB career, Bassitt has surrendered 1,215 hits while he has tallied 1,201 strikeouts in 1,299 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Baltimore (-132)

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