Houston Astros vs Chicago White Sox Prediction, 7/25/2026 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Chicago White Sox

Date: Saturday, July 25, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Houston (-130) Chicago (+110)

The Houston Astros (50-54) are en route to Rate Field on Saturday where they will go up against the Chicago White Sox (54-47). The line on this contest has Houston at -130 while Chicago is at +110. The betting total is set at 8. The expected starting pitchers will be Hunter Brown and Sean Burke.

As a unit, the Houston Astros are compiling 4.6 runs per outing, which is 12th in the league. They have racked up 473 runs scored while holding a team OBP of .315. The Astros have recorded 156 doubles as a team and have knocked 142 baseballs out of the park. They have compiled 452 runs batted in in addition to 843 hits on the season, while their team batting average is .242. Houston is slugging .413 and have been rung up 841 times, while taking a walk on 341 occasions.

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Their strikeout to walk ratio sits at 2.02 and the pitching staff sits with a WHIP of 1.39. Astros pitchers have surrendered 142 long balls in addition to 518 total runs (25th in baseball). Houston has relinquished 829 base hits (8.1 per 9 innings) as well as 482 earned runs. The Astros have a team earned run average of 4.71 for the year (25th in the league), and they have rung up 915 hitters. Their pitching staff has walked 453 hitters and their FIP is 4.80 as a team so far this season.

The Astros have sent 328 relievers to the hill so far this season. The bullpen pitchers have inherited 140 base runners this year with 28.6% of them ended up scoring. The bullpen have tallied 46 holds this season (24th in MLB). Astros relief pitchers have come into the game with players on base 93 times and also have had 101 appearances in high leverage situations. They have accumulated 30 saves this season and have blown 6 of 36 chances to get a save. The Astros relief pitchers have recorded a save percentage of 83.3% and stepped onto the hill in 82 save situations.

The Astros have turned 70.7% of balls in play into outs out of 8,292 innings on the diamond, which ranks them 10th in the majors. The Houston Astros have accumulated 2,764 putouts so far this season, in addition to 752 assists and 43 errors. Their fielding rate sits at .988 which has them ranked 7th in MLB, and have 82 double plays.

Brown has taken the mound for 571 innings and has racked up 628 punch outs in his career. Brown (37-32 career record) has a FIP of 3.48 while facing 2,363 batters in the major leagues. His ERA is 3.53 (224 earned runs allowed) and his career WHIP is 1.222. He has surrendered 491 hits (7.7 hits per nine innings) and has 207 walks.

The White Sox hold a slugging percentage of .409 and they are scoring 4.78 runs per game (8th in MLB). They have tallied 157 doubles, while getting a free base 342 times as well as putting up 483 runs. Chicago has recorded 131 home runs so far this season as well as 464 runs batted in. They have been called out on strikes on 906 occasions (7th in MLB) and have totaled 809 hits. The Chicago White Sox hold an on-base percentage of .318 as well as a batting average of .240 over the course of the season.

The White Sox have a team WHIP of 1.309 with a FIP of 4.23 as a staff so far this season. Their strikeout to walk ratio comes in at 8.60 (853 strikeouts against 375 walks). They rank 7th in baseball as a pitching staff in total hits surrendered with 795. They have conceded 109 homers and they allow 4.42 runs per 9 innings (10th in MLB). The Chicago pitching staff have given up 439 runs for the year while holding an ERA of 4.08 (405 earned runs surrendered).

They rank 19th in the league with a save rate of 59.6%, and they have dispatched 339 relievers onto the diamond for the season. Their relief pitchers have stepped onto the mound 99 times in high leverage situations and also on 107 occasions with runners on. With 85 save situations, the White Sox have accrued 38 holds and 19 blown saves. Chicago has had relievers step onto the mound in 47 save chances and they have recorded 28 saves. Chicago relief pitchers have an inherited score percentage of 30.2% out of their 159 inherited base runners.

The Chicago White Sox have turned 72 double plays and have a fielding percentage of .986 (15th in MLB). The White Sox have accrued 837 assists, 50 errors and have accounted for 2,682 putouts this year. Out of their 8,046 innings on the diamond, the White Sox have accumulated a defensive efficiency of 70.5% (11th in professional baseball).

Burke (13-15 record in his career) has earned a 3.60 earned run average and has allowed 8.0 hits per 9 innings. He has a strikeout to walk ratio of 2.64 and he has gone up against 1,130 hitters during his pro baseball career. He has conceded 106 ER's while holding a WHIP of 1.282 and being the owner of a FIP of 3.5. So far in his pro baseball career, Burke has surrendered 236 hits while totaling 275 K's in 265 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Houston (-130)

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