Houston Astros vs Cleveland Guardians Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Cleveland Guardians

Date: Wednesday, April 22, 2026

Location: Progressive Field in Cleveland, OH

TV: MLB.TV

Odds/Point Spread: Houston (-128) Cleveland (+106)

The Houston Astros (9-15) are on their way to Progressive Field on Wednesday where they will try to beat the Cleveland Guardians (13-11). The odds on this game have the Astros at -128 while the Guardians are opening at +106. The betting total comes in at 8. The pitchers expected to start will be Peter Lambert and Tanner Bibee.

The Astros have accrued 55 doubles as a unit and have hit 30 baseballs out of the stadium. Houston has a slugging percentage of .440 and have struck out 186 times, while drawing a walk on 107 occasions. As a squad, the Houston Astros are notching 5.4 runs per outing, which ranks them 4th in the league. They have accrued 122 RBI's as well as 213 base knocks on the season, while their average at the plate is at .260. They have accumulated 130 runs while holding a team OBP of .350.

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They have a K/BB ratio of 1.77 and their pitching staff has a collective WHIP of 1.63. Astros pitchers have given up 34 home runs in addition to 142 total runs (29th in MLB). Houston has allowed 211 hits (9.1 per 9 innings) and 138 earned runs. The Astros have compiled a team earned run average of 5.93 so far this year (30th in the league), and their staff has rung up 228 batters. Their pitching staff has walked 129 opposing hitters and their FIP is 5.20 as a unit so far this season.

Astros pitchers have gone to the mound with players on base 30 times in addition to having 16 appearances in high leverage situations. The relievers are sitting with 8 holds this year (28th in the league). The Astros relievers have recorded a save percentage of 100.0% and stepped onto the hill in 13 save situations. They have accumulated 5 saves this season and have not converted 0 out of their 5 save chances. The bullpen pitchers have inherited 51 base runners this year with 31.4% of those runners crossing the plate. The Astros have sent 77 relief pitchers to the hill on the year.

The Detroit Tigers have 628 putouts this season, as well as 172 assists and 9 errors. Their fielding percentage is currently at .989 which is 8th in MLB, and have 22 double plays. The Astros have turned 66.8% of balls in play into outs in their 1,884 innings on the field, which has them sitting 29th in pro baseball.

Lambert has taken the ball for 248 innings and has earned 189 K's during his career. His ERA is 6.31 (174 ER's allowed) and he has a WHIP of 1.612. He has surrendered 304 hits (11.0 hits per 9 innings) and has had 96 walks. Lambert (8-20 career record) has a FIP of 6.21 while he has faced 1,129 hitters in the major leagues.

The Cleveland Guardians have earned an on-base percentage of .314 in addition to a team batting average of .227 for the year. They have struck out on 186 occasions (18th in the league) and have earned 176 hits. Cleveland has accumulated 25 home runs on the year as well as 92 runs batted in. The Guardians have a team slugging % of .378 and they score 4.04 runs per contest (21st in the league). They have 43 doubles, while taking a walk 92 times as well as racking up 97 runs.

The Guardians have a team WHIP of 1.270 and have a FIP of 4.21 as a team on the campaign. Their K/BB ratio is 9.90 (233 strikeouts vs 88 walks). They sit at 20th in the league as a staff in total hits allowed with 180. They have relinquished 31 homers and they relinquish 4.43 runs per 9 innings (14th in the league). The Cleveland pitching staff have relinquished 104 runs over the course of the season while holding a team ERA of 4.09 (96 earned runs relinquished).

They are currently ranked 9th in baseball with a save percentage of 70.0%, and they have dispatched 76 relievers onto the diamond on the year. Their relievers have come in 27 times in high leverage situations in addition to 22 occasions with runners on. With 26 save situations, the Guardians have accumulated 16 holds in addition to 3 blown saves. Cleveland has called on bullpen pitchers to enter the contest in 10 save chances and they have tallied 7 saves. Cleveland bullpen pitchers hold an inherited score percentage of 37.8% out of their 37 inherited base runners.

The Cleveland Guardians have gotten 20 double plays and hold a fielding percentage of .988 (10th in professional baseball). The Guardians have 171 assists, 10 errors and have notched a total of 634 putouts over the course of the season. Out of their 1,902 innings on the diamond, the Guardians have accumulated a efficiency on defense of 70.7% (13th in the majors).

So far in his career, Bibee has conceded 470 base hits while totaling 513 punch outs in 522 innings. Bibee (34-25 record in his career) is the owner of a 3.67 earned run average while conceding 8.1 hits per 9 innings. He has given up a total of 213 earned runs while holding a WHIP of 1.191 and a FIP of 3.6. He has a strikeout to walk ratio of 3.38 and he has gone up against 2,164 hitters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cleveland (+106)

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