Houston Astros vs Sacramento Athletics Prediction, 9/25/2026 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Sacramento Athletics

Date: Friday, September 25, 2026

Location: Sutter Health Park in West Sacramento, CA

TV: NBC Sports California

Odds/Point Spread: Houston (-144) Sacramento (+120)

Sutter Health Park is the site where the Sacramento Athletics (62-95) will try to defeat the Houston Astros (78-79) on Friday. The moneyline on this game has Houston at -144 and Sacramento is sitting at +120. The over/under is set at 8. The starting pitchers will be Hayden Wesneski and Jacob Lopez.

As a team, the Houston Astros are notching 4.4 runs per game, which ranks them 18th in the league. They have accounted for 695 runs while holding a team OBP of .314. The Astros have hit 229 two-baggers as a squad and have hit 212 balls out of the park. They have accumulated 664 runs batted in as well as 1,267 hits over the course of the season, while their batting average is at .240. Houston has a slugging percentage of .411 and have struck out 1,290 times, while being walked on 507 occasions.

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The Astros have a team earned run average of 4.50 this season (24th in the league), and their staff has struck out 1,368 hitters. Astros pitchers have conceded 201 home runs and 747 runs (24th in the league). Their pitching staff has walked 631 opposing players and their FIP is 4.56 as a unit this year. Houston has conceded 1,237 base knocks (8.0 per 9 innings) in addition to 696 earned runs. Their strikeout to walk ratio is 2.17 and their pitching staff has earned a collective WHIP of 1.34.

The Astros relief pitchers have recorded a save rate of 78.7% and stepped onto the hill in 149 save situations. They have accumulated 48 saves for the year and have blown 13 of 61 save opportunities. The relievers have inherited 222 base runners this year and 26.1% of those players earned a run for their team. Astros relief pitchers have stepped onto the hill with runners on 147 times in addition to having 160 appearances in high leverage situations. The Astros have sent 510 relievers to the hill for the season. The bullpen have a total of 86 holds over the course of the season (13th in MLB).

The Houston Astros have amassed 4,178 putouts on the year, in addition to 1,156 assists and 70 errors. Their fielding rate sits at .987 which has them sitting 10th in pro baseball, and they have turned 124 double plays. The Astros have converted 70.9% of balls in play into outs out of 12,534 innings, which has them sitting at 9th in pro baseball.

Wesneski has pitched in 276 innings and has racked up 253 punch outs so far in his career. His ERA is 3.91 (120 earned runs allowed) and his career WHIP is 1.156. He has allowed 234 hits (7.6 hits per nine innings) and has had 85 walks. Wesneski (15-18 career win-loss record) has a FIP of 3.85 and he has faced 1,144 batters in the majors.

Sacramento has accounted for 190 home runs on the season as well as 650 runs batted in. They have put up 237 two-baggers, while getting a free base 505 times and scoring 679 runs. The Sacramento Athletics have accounted for an on-base percentage of .317 as well as a team batting average of .245 this season. The Athletics have a slugging percentage of .403 and they average 4.32 runs per game (21st in MLB). They have been called out on strikes on 1,332 occasions (12th in the league) and have earned a total of 1,302 base knocks.

The Athletics have a WHIP of 1.506 and have a FIP of 4.87 as a pitching staff so far this year. They are sitting at 29th in the league as a staff in total hits relinquished with 1,472. The Sacramento pitching staff have conceded 900 runs so far this year while holding a team ERA of 5.45 (838 earned runs relinquished). Their K/BB ratio comes in at 8.50 (1,307 strikeouts against 614 walks). They have conceded 232 long balls and they concede 5.85 runs per 9 innings (29th in MLB).

They are ranked 22nd in the league holding a save percentage of 57.6%, and they have dispatched 537 relievers onto the field over the course of the season. Their relief pitchers have stepped onto the mound 147 times in high leverage situations and on 175 occasions with runners on. With 152 save situations, the Athletics have accumulated 83 holds and 28 blown saves. Sacramento has had relief pitchers take the mound in 66 save chances and they have come away with 38 saves. Sacramento relievers have an inherited score percentage of 36.5% out of 266 inherited runners.

Out of their 12,465 innings on the field, the Athletics are sitting with a defensive efficiency of 67.5% (29th in professional baseball). The Sacramento Athletics have turned 118 double plays and hold a fielding percentage of .986 (13th in baseball). The Athletics have recorded 1,195 assists, 75 errors and have a tally of 4,155 putouts on the campaign.

Lopez (14-12 career record) has earned a 4.96 ERA while allowing 8.7 hits per 9 innings. He has a K/BB ratio of 2.32 and he has faced 1,028 opposing batters so far in his pro baseball career. He has conceded a total of 128 earned runs while holding a WHIP of 1.404 and being the owner of a FIP of 4.9. During his pro baseball career, Lopez has conceded 224 base knocks and he has 237 K's in 232 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Sacramento (+120)

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