Houston Astros vs San Francisco Giants Prediction, 8/12/2026 MLB Picks, Best Bets & Odds

Game: Houston Astros vs San Francisco Giants

Date: Wednesday, August 12, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Houston (-128) San Francisco (+106)

The Houston Astros (60-59) are headed to Oracle Park on Wednesday where they will try to beat the San Francisco Giants (49-69). The line on this matchup has the Astros at -128 and the Giants are coming in at +106. The over/under is set at 8.5. The pitchers taking the mound are Ronel Blanco and Adrian Houser.

As a unit, the Houston Astros are putting up 4.6 runs per outing, which has them sitting at 10th in MLB. They have tallied 550 runs scored and have an OBP of .321. The Astros have hit 179 two-baggers as a unit and have knocked 161 balls out of the stadium. They have amassed 523 RBI's in addition to 983 hits for the season, and their team batting average is sitting at .245. Houston has a slugging rate of .415 and have been rung up 969 times, while drawing a walk on 402 occasions.

Get all of our MLB Picks

Their K/BB ratio is 2.10 and their pitching staff holds a collective WHIP of 1.36. Astros pitchers have yielded 161 home runs and 578 total runs (24th in baseball). Houston has surrendered 938 base knocks (8.0 per 9 innings) as well as 538 earned runs. The Astros have compiled a team earned run average of 4.59 for the year (25th in the league), and the staff has rung up 1,038 batters. Their pitching staff has walked 494 opposing batters and their FIP sits at 4.72 as a team so far this season.

The Astros bullpen have a save rate of 84.1% and have come into the game in 102 save situations. They have compiled 37 saves so far this year and have blown 7 out of their 44 chances to get a save. The relievers have inherited 161 runners over the course of the season and 26.1% of them ended up scoring. Astros relief pitchers have come into the game with opponents on base 108 times and also have had 116 appearances in high leverage situations. The Astros have dispatched 379 relief pitchers to the mound on the year. The relief pitchers are sitting with 56 holds over the course of the season (21st in the league).

The Houston Astros have 3,163 putouts this year, in addition to 875 assists and 51 errors. Their fielding percentage sits at .988 which puts them in 9th in baseball, and they have turned 93 double plays. The Astros have transformed 71.1% of baseballs in play into outs out of their 9,489 innings on the field, which ranks them 7th in pro baseball.

Blanco has taken the mound for 293 innings and has earned 290 K's in his MLB career. His ERA is 3.68 (120 earned runs allowed) and he has a career WHIP of 1.208. He has conceded 223 base knocks (6.8 hits per 9 innings) with 131 walks. Blanco (18-12 career mark) holds a FIP of 3.63 while he has gone up against 1,214 opposing hitters in the majors.

The Giants hold a team slugging percentage of .409 and they score 4.11 runs per outing (26th in baseball). They have tallied 200 two-baggers, while taking a walk 309 times as well as racking up 485 runs. San Francisco has a total of 131 long balls for the season and 466 runs batted in. They have struck out on 930 instances (25th in baseball) and have earned a total of 1,001 base knocks. The San Francisco Giants have tallied an on-base percentage of .307 as well as a batting average of .249 so far this season.

The Giants hold a team WHIP of 1.364 and have a FIP of 4.18 as a staff for the year. They are sitting at 18th in the league as a pitching staff in total hits given up with 978. The San Francisco pitching staff have allowed 548 runs on the season while holding a team ERA of 4.37 (505 earned runs conceded). They have earned a strikeout to walk ratio of 7.70 (893 strikeouts vs 441 bases on balls). They have conceded 112 HR's and they give up 4.74 runs per 9 innings (20th in baseball).

With 93 save situations, the Giants have accumulated 56 holds and also 15 blown saves. San Francisco has called on relief pitchers to enter the contest in 37 save opportunities and they have come away with 22 saves. San Francisco relievers hold an inherited score rate of 34.7% out of 196 inherited base runners. Their relief pitchers have come in 95 times in high leverage situations and on 130 occasions with base runners. They are ranked 19th in baseball with a save percentage of 59.5%, and they have dispatched 368 relief pitchers to the mound on the campaign.

The San Francisco Giants have turned 110 double plays and hold a fielding percentage of .983 (24th in MLB). The Giants have racked up 1,104 assists, 75 errors and have a total of 3,120 putouts during this campaign. In their 9,360 innings played, the Giants have accumulated a defensive efficiency of 69.4% (19th in baseball).

During his pro baseball career, Houser has surrendered 818 hits while totaling 641 strikeouts in 830 innings. Houser (43-51 record in his career) has a 4.12 ERA while giving up 8.9 hits per nine innings. He has surrendered 380 earned runs while earning a WHIP of 1.362 and a FIP of 4.1. His K/BB ratio is 2.05 and he has faced 3,561 hitters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Houston (-128)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.