Houston Astros vs Seattle Mariners Prediction, 9/23/2026 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Seattle Mariners

Date: Wednesday, September 23, 2026

Location: T-Mobile Park in Seattle, WA

TV: MLB.TV

Odds/Point Spread: Houston (+106) Seattle (-128)

T-Mobile Park is the site where the Seattle Mariners (73-83) will take on the Houston Astros (77-79) on Wednesday. The moneyline on this game has Houston at +106 while Seattle is priced at -128. The over/under is set at 9. The men taking the mound are Ethan Pecko and George Kirby.

Houston has a slugging % of .410 and have been called out on strikes 1,282 times, while taking a walk on 502 occasions. They have tallied 657 runs batted in and 1,255 base knocks over the course of the season, and their average at the plate sits at .240. The Astros have compiled 228 two-baggers as a squad and have knocked 209 balls out of the stadium. They are sitting with 688 runs and have an on-base percentage of .313. As a unit, the Houston Astros are scoring 4.4 runs per game, which is 19th in baseball.

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They have accrued a K/BB ratio of 2.17 and their pitching staff holds a collective WHIP of 1.34. Astros pitchers have surrendered 201 home runs in addition to 747 runs (24th in the league). Houston has given up 1,233 hits (8.0 per 9 innings) as well as 696 earned runs. The Astros hold a team earned run average of 4.53 so far this year (24th in the league), and the staff has rung up 1,359 batters. They have walked 626 hitters and their FIP comes in at 4.57 as a squad for the season.

The Astros have sent 506 relievers to the hill so far this year. The relievers have inherited 222 runners on the season with 26.1% of those players earned a run for their team. The relief pitchers have a total of 86 holds for the year (12th in the league). Astros relief pitchers have stepped onto the hill with runners on base 147 times as well as having 160 appearances in high leverage situations. They have recorded 48 saves on the year and have not converted 13 out of their 61 chances to save the game. The Astros bullpen have a save rate of 78.7% and have entered the game in 149 save situations.

The Astros have converted 70.8% of baseballs in play into outs out of their 12,453 innings, which ranks them 9th in MLB. The Houston Astros have a total of 4,151 putouts on the campaign, as well as 1,155 assists and 70 errors. Their fielding percentage is holding steady at .987 which puts them in 10th in baseball, and have a total of 123 double plays.

Pecko has taken the mound for 28 frames and has accounted for 19 punch outs during his MLB career. His earned run average is 3.83 (12 earned runs allowed) and his WHIP is 1.135. He has surrendered 20 hits (6.4 hits per 9 innings) and has 12 free passes. Pecko (1-0 career record) sits with a FIP of 3.77 and he has gone up against 116 opposing hitters during his time in the major leagues.

The Seattle Mariners have an on-base percentage of .312 and a batting average of .232 so far this season. They have been called out on strikes on 1,352 instances (9th in baseball) and have tallied 1,202 hits. Seattle has compiled 179 long balls for the season as well as 611 RBIs. The Mariners have a team SLG% of .380 and they tally 4.06 runs per contest (28th in MLB). They have hit 198 doubles, while getting a free base 526 times and scoring 634 runs.

The Mariners hold a team WHIP of 1.260 in addition to having a FIP of 3.99 as a squad this season. They come in at 22nd in MLB as a pitching staff in total hits surrendered with 1,318. The Seattle pitching staff have given up 690 runs this season and come in with a team ERA of 4.19 (640 earned runs yielded). Their K/BB ratio comes in at 8.70 (1,328 strikeouts vs 415 walks). They have allowed 187 HR's and they yield 4.52 runs per 9 innings (15th in MLB).

Seattle relievers hold an inherited score percentage of 32.4% of 173 inherited runners. Their relief pitchers have taken the field 161 times in high leverage situations and on 123 occasions with runners on base. With 144 save situations, the Mariners have earned 80 holds and 28 blown saves. They are ranked 25th in baseball with a save rate of 55.6%, and they have sent 482 bullpen pitchers to the mound on the season.

The Seattle Mariners have turned 121 double plays and hold a fielding percentage of .985 (18th in baseball). The Mariners have 1,286 assists, 83 errors and have 4,126 putouts this season. Out of their 12,378 innings played, the Mariners have accumulated a defensive efficiency of 68.9% (25th in baseball).

Kirby (54-45 career mark) holds a 3.73 ERA while giving up 9.0 hits per nine innings. His strikeout to walk ratio is 5.58 and he has faced 3,319 batters during his MLB career. He has conceded 334 ER's while earning a WHIP of 1.171 and being the owner of a FIP of 3.7. In his pro baseball career, Kirby has conceded 807 hits and he has 764 punch outs in 806 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Houston (+106)

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