Los Angeles Angels vs Seattle Mariners Prediction, 9/25/2026 MLB Picks, Best Bets & Odds

Game: Los Angeles Angels vs Seattle Mariners

Date: Friday, September 25, 2026

Location: T-Mobile Park in Seattle, WA

TV: MLB.TV

Odds/Point Spread: Los Angeles (+110) Seattle (-130)

The Los Angeles Angels (60-97) are traveling to T-Mobile Park on Friday where they will attempt to defeat the Seattle Mariners (73-84). The line on this matchup has the Angels at +110 and the Mariners are coming in at -130. The over/under is set at 9. The pitchers who are expected to start are Reid Detmers and Bryce Miller.

The Angels have hit 233 doubles as a team and have knocked 149 baseballs out of the park. Los Angeles owns a slugging percentage of .369 and have struck out 1,498 times, while being walked on 490 occasions. As a unit, the Los Angeles Angels are recording 4.0 runs per game, which has them at 29th in MLB. They have accrued 605 RBI's and 1,226 hits over the course of the season, and their batting average is sitting at .234. They have notched a total of 632 runs and have an OBP of .309.

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They have earned a K/BB ratio of 2.27 and the pitching staff has a collective WHIP of 1.34. Angels pitchers have conceded 160 home runs in addition to 721 runs in total (20th in the league). Los Angeles has allowed 1,247 base hits (8.1 per 9 innings) as well as 654 earned runs. The Angels are sitting with a team ERA of 4.24 on the year (20th in MLB), and the staff has rung up 1,402 batters. They have walked 617 opposing hitters and their FIP sits at 4.08 as a squad on the campaign.

The Angels relief pitchers have accumulated a save percentage of 44.4% and have stepped onto the mound in 147 save situations. They have tallied 24 saves over the course of the season and have blown 30 of their 54 save opportunities. The bullpen pitchers have inherited 239 runners for the year with 38.1% of them crossing home plate. Angels pitchers have entered the contest with runners on base 160 times in addition to having 166 appearances in high leverage situations. The Angels have sent 504 relievers to the hill for the year. The relief pitchers have earned 90 holds so far this year (10th in the league).

The Los Angeles Angels have earned 4,165 putouts for the season, in addition to 1,326 assists and 87 errors. Their fielding rate is at .984 which has them ranked 19th in professional baseball, and have accumulated 110 double plays. The Angels have converted 69.4% of balls in play into outs out of 12,495 innings, which has them ranked 20th in pro baseball.

Detmers has taken the hill for 628 innings and has earned 702 punch outs in his MLB career. Detmers (27-39 career win-loss mark) has a FIP of 4.33 and he has gone up against 2,659 hitters in the majors. His ERA is 4.40 (307 earned runs allowed) and his WHIP is 1.275. He has allowed 575 hits (8.2 hits per nine innings) and has 226 walks.

The Seattle Mariners are sitting with a team OBP of .312 as well as a team batting average of .231 this season. They have been rung up on 1,361 occasions (9th in the league) and have earned 1,206 hits. Seattle has recorded 179 home runs this year to go along with 611 runs batted in. The Mariners have a SLG% of .379 and they average 4.04 runs per contest (28th in baseball). They have put up 198 doubles, while taking a walk 531 times and scoring 634 runs.

The Mariners have a WHIP of 1.264 and have a FIP of 4.01 as a pitching staff over the course of the season. They sit at 22nd in baseball as a pitching staff in total hits given up with 1,330. The Seattle pitching staff have conceded 697 runs this season while having an ERA of 4.21 (647 earned runs yielded). Their K/BB ratio sits at 8.70 (1,336 strikeouts vs 420 free passes). They have surrendered 190 home runs and they concede 4.53 runs per 9 innings (16th in the league).

With 144 save situations, the Mariners have tallied 80 holds in addition to 28 blown saves. Seattle has called on relievers to step onto the hill in 63 save chances and they have earned 35 saves. Seattle bullpen pitchers hold an inherited score percentage of 32.4% out of their 173 inherited base runners. Their relief pitchers have taken the field 161 times in high leverage situations and on 123 occasions with runners on base. They are ranked 25th in baseball with a save rate of 55.6%, and they have sent 486 relief pitchers onto the field on the year.

The Seattle Mariners have turned 123 double plays and have earned a fielding percentage of .985 (18th in professional baseball). The Mariners have accrued 1,293 assists, 84 errors and have earned 4,153 putouts during this campaign. Out of their 12,459 innings on the field, the Mariners have accumulated a defensive efficiency of 68.9% (26th in the majors).

Miller (28-30 record in his career) has a 4.01 ERA and has surrendered 7.7 hits per 9 innings. He has a K/BB ratio of 3.38 and he has gone up against 2,092 hitters in his MLB career. He has given up a total of 229 earned runs while holding a WHIP of 1.134 and being the owner of a FIP of 3.9. During his MLB career, Miller has allowed 442 hits while totaling 476 K's in 514 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Seattle (-130)

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