Los Angeles Dodgers vs Houston Astros Prediction, 5/6/2026 MLB Picks, Best Bets & Odds

Game: Los Angeles Dodgers vs Houston Astros

Date: Wednesday, May 6, 2026

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: Los Angeles (-145) Houston (+125)

The Los Angeles Dodgers (22-13) are traveling to Daikin Park on Wednesday where they will try to beat the Houston Astros (14-22). The moneyline on this game has the Dodgers at -145 and the Astros are coming in at +125. The total comes in at 8.5. The expected starting pitchers are Tyler Glasnow and Lance McCullers Jr..

As a squad, the Los Angeles Dodgers are recording 5.2 runs per contest, which has them at 4th in MLB. They have notched a total of 183 runs scored while holding a team OBP of .352. The Dodgers have accounted for 58 two-baggers as a team and have smacked 47 balls out of the park. They have accumulated 174 RBI's as well as 324 hits over the course of the season, and their team batting average is .273. Los Angeles has a slugging % of .443 and have been rung up 279 times, while drawing a walk on 139 occasions.

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The Dodgers are sitting with a team earned run average of 3.21 on the campaign (2nd in the league), and their staff has struck out 310 batters. Dodgers pitchers have allowed 31 home runs and 115 runs in total (1st in the league). Their pitching staff has walked 105 opposing batters and their FIP comes in at 3.61 as a team on the campaign. Los Angeles has allowed 241 hits (7.0 per 9 innings) as well as 110 earned runs. They have a K/BB ratio of 2.95 and their pitching staff has recorded a WHIP of 1.12.

Dodgers pitchers have gone to the mound with players on base 20 times as well as having 30 appearances in high leverage situations. The relief pitchers have racked up 18 holds this year (20th in MLB). The Dodgers relievers have compiled a save rate of 61.5% and have come into the game in 31 save situations. They have accumulated 8 saves this season and have missed out on 5 out of their 13 save chances. The bullpen pitchers have inherited 34 runners for the year with 23.5% of them ended up scoring. The Dodgers have dispatched 105 relievers to the mound over the course of the season.

The Los Angeles Dodgers are sitting with 924 putouts thus far, as well as 282 assists and 13 errors. Their fielding percentage is currently at .989 which has them ranked 5th in baseball, and they have turned 22 double plays. The Dodgers have converted 72.6% of balls hit into play into outs out of 2,772 innings, which has them ranked 3rd in pro baseball.

Glasnow has taken the mound for 792 frames and is sitting with 999 strikeouts during his pro baseball career. His ERA is 3.68 (324 ER's allowed) and his career WHIP is 1.132. He has surrendered 594 base hits (6.7 hits per nine innings) with 303 walks. Glasnow (46-36 career record) has a FIP of 3.63 while he has faced 3,229 opposing hitters in the majors.

The Astros hold a team slugging percentage of .436 and they tally 5.03 runs per contest (8th in the league). They have put up 73 doubles, while walking 139 times and racking up 181 runs. Houston has compiled 44 home runs this season to go along with 171 RBIs. They have been called out on strikes on 284 occasions (18th in baseball) and are sitting with 331 base knocks. The Houston Astros have earned an on-base percentage of .346 and a team batting average of .267 on the campaign.

The Houston pitching staff have conceded 209 runs for the season and come in with a team ERA of 5.79 (202 earned runs conceded). They have yielded 50 HR's and they allow 5.99 runs per 9 innings (30th in baseball). The Astros have a team WHIP of 1.633 and are the owners of a FIP of 5.20 as a squad for the season. Their strikeout to walk ratio sits at 9.30 (326 strikeouts against 192 bases on balls). They come in at 27th in baseball as a pitching staff in total hits relinquished with 321.

Houston relievers hold an inherited score rate of 28.4% of 74 inherited runners. Their bullpen pitchers have stepped onto the mound 29 times in high leverage situations in addition to 43 occasions with base runners. With 21 save situations, the Astros have tallied 13 holds in addition to 1 blown save. They are ranked 1st in baseball with a save rate of 87.5%, and they have sent 117 relief pitchers onto the field for the year.

The Houston Astros have turned 36 double plays and have notched a fielding percentage of .989 (4th in the majors). The Astros have recorded 272 assists, 13 errors and have a total of 943 putouts for the year. Out of their 2,829 innings played, the Astros have accumulated a defensive efficiency of 67.0% (28th in professional baseball).

During his MLB career, McCullers has conceded 691 base knocks while earning 894 K's in 805 frames. He has surrendered a total of 340 ER's while earning a WHIP of 1.295 and being the owner of a FIP of 3.7. He has a strikeout to walk ratio of 2.54 and he has gone up against 3,424 opposing hitters in his pro baseball career. McCullers (53-39 career mark) is the owner of a 3.80 ERA while conceding 7.7 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Los Angeles (-145)

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