Los Angeles Dodgers vs San Diego Padres Prediction, 5/20/2026 MLB Picks, Best Bets & Odds

Game: Los Angeles Dodgers vs San Diego Padres

Date: Wednesday, May 20, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Los Angeles (-150) San Diego (+125)

The Los Angeles Dodgers (28-18) are en route to Petco Park on Wednesday where they will try to defeat the San Diego Padres (27-18). The moneyline on this contest has the Dodgers at -150 while the Padres are sitting at +125. The total comes in at 8. The pitchers who are expected to start are Shohei Ohtani and Randy Vasquez.

As a team, the Los Angeles Dodgers are putting up 5.3 runs per game, which puts them at 3rd in MLB. They have accounted for 248 runs while holding a team on-base percentage of .345. The Dodgers have recorded 75 two-baggers as a unit and have smacked 62 balls out of the park. They have recorded 233 RBI's in addition to 417 base knocks on the year, and their batting average is at .264. Los Angeles has a slugging % of .433 and have been called out on strikes 373 times, while being walked on 189 occasions.

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They have earned a K/BB ratio of 3.18 and their pitching staff holds a collective WHIP of 1.10. Dodgers pitchers have surrendered 41 home runs in addition to 154 runs (2nd in baseball). Los Angeles has conceded 325 base hits (7.0 per 9 innings) and also 148 earned runs. The Dodgers have an earned run average of 3.21 on the year (2nd in MLB), and their staff has struck out 423 batters. They have walked 133 opposing batters and their FIP is 3.46 as a team on the year.

The Dodgers have sent 146 relief pitchers to the hill over the course of the season. The bullpen pitchers have inherited 44 base runners so far this year with 29.5% of those players crossing the plate. The relievers have notched 23 holds on the campaign (19th in baseball). Dodgers pitchers have stepped onto the hill with runners on 26 times and also have had 36 appearances in high leverage situations. They have compiled 10 saves this year and have blown 5 out of their 15 save chances. The Dodgers relief pitchers have recorded a save rate of 66.7% and have come into the game in 38 save situations.

The Los Angeles Dodgers have a total of 1,245 putouts for the season, in addition to 378 assists and 15 errors. Their fielding rate is at .991 which has them sitting 2nd in pro baseball, and they have turned 27 double plays. The Dodgers have converted 72.6% of balls in play into outs out of their 3,735 innings, which has them ranked 2nd in MLB.

Ohtani has taken the ball for 572 frames and has earned 720 K's in his MLB career. His earned run average is 2.83 (180 earned runs allowed) and he has a WHIP of 1.059. He has conceded 413 base hits (6.5 hits per nine innings) and has 193 walks. Ohtani (42-22 win-loss record in his career) has earned a FIP of 2.79 while he has faced 2,310 hitters in the major leagues.

San Diego has 46 home runs on the season as well as 188 RBIs. They have notched 71 two-baggers, while taking a walk 147 times and earning 195 runs. The San Diego Padres have earned a team on-base percentage of .296 in addition to a team batting average of .224 so far this season. The Padres have a team slugging percentage of .371 and they earn 4.24 runs per outing (19th in MLB). They have been rung up on 392 occasions (14th in MLB) and have totaled 339 base hits.

The Padres have a team WHIP of 1.246 and are the owners of a FIP of 3.58 as a squad for the year. Their strikeout to walk ratio is 8.80 (403 strikeouts vs 153 bases on balls). They are sitting at 8th in baseball as a staff in total hits allowed with 358. They have given up 37 long balls and they concede 4.13 runs per 9 innings (8th in MLB). The San Diego pitching staff have surrendered 188 runs for the season while holding an ERA of 4.02 (183 earned runs yielded).

They sit at 8th in the league holding a save percentage of 70.8%, and they have sent 153 relievers to the hill on the campaign. Their bullpen pitchers have come in 49 times in high leverage situations in addition to 42 occasions with runners on. With 58 save situations, the Padres have earned 32 holds in addition to 7 blown saves. San Diego has called on bullpen pitchers to enter the contest in 24 save chances and they have converted 17 saves. San Diego bullpen pitchers have an inherited score percentage of 35.6% out of their 73 inherited runners.

Out of their 3,690 innings on the diamond, the Padres have earned a efficiency on defense of 70.3% (15th in MLB). The San Diego Padres have turned 32 double plays and have a fielding percentage of .992 (1st in pro baseball). The Padres have recorded 410 assists, 14 errors and have a tally of 1,230 putouts so far this season.

So far in his career, Vasquez has given up 317 base hits while he has earned 218 punch outs in 319 innings. Vasquez (17-17 win-loss record in his career) has a 3.86 earned run average and has allowed 8.9 hits per 9 innings. He has allowed 137 ER's while earning a WHIP of 1.344 and a FIP of 3.8. He has a strikeout to walk ratio of 1.95 and he has faced 1,370 hitters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take San Diego (+125)

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