Los Angeles Dodgers vs San Francisco Giants Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: Los Angeles Dodgers vs San Francisco Giants

Date: Wednesday, April 22, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Los Angeles (-122) San Francisco (+102)

The San Francisco Giants (9-13) welcome the Los Angeles Dodgers (16-6) at Oracle Park on Wednesday. The moneyline on this contest has Los Angeles at -122 and San Francisco is at +102. The betting total comes in at 9. The starting pitchers are Shohei Ohtani and Tyler Mahle.

Los Angeles is slugging .507 and have been called out on strikes 188 times, while taking a walk on 84 occasions. They have tallied 128 runs batted in and 222 base knocks this season, and their average at the plate comes in at .293. The Dodgers have accumulated 34 two-baggers as a team and have hit 42 baseballs out of the stadium. They have earned 133 runs while holding a team on-base percentage of .366. As a squad, the Los Angeles Dodgers are compiling 6.1 runs per outing, which ranks them 1st in MLB.

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They have accrued a K/BB ratio of 2.73 and their pitching staff holds a collective WHIP of 1.12. Dodgers pitchers have conceded 18 home runs and also 76 total runs (2nd in baseball). Los Angeles has given up 151 hits (7.0 per 9 innings) and also 74 earned runs. The Dodgers have compiled a team earned run average of 3.42 so far this year (8th in MLB), and their staff has struck out 183 hitters. Their pitching staff has walked 67 opposing batters and their FIP sits at 3.59 as a squad on the season.

The Dodgers have sent 69 relief pitchers to the hill on the year. The relievers have inherited 24 runners on the season with 29.2% of those runners crossing home plate. The relief pitchers have racked up 14 holds so far this year (13th in the league). Dodgers relief pitchers have entered the game with opponents on base 14 times in addition to having 23 appearances in high leverage situations. They have accumulated 6 saves for the year and have not converted 4 out of their 10 chances to save the game. The Dodgers relief pitchers have accumulated a save rate of 60.0% and have come into the game in 24 save situations.

The Dodgers have transformed 73.7% of balls in play into outs out of their 1,755 innings on the diamond, which has them ranked 2nd in professional baseball. The Los Angeles Angels are sitting with 585 putouts on the campaign, as well as 188 assists and 5 errors. Their fielding percentage sits at .994 which is 2nd in professional baseball, and have accumulated 14 double plays.

Ohtani (41-20 career record) has a FIP of 2.87 and he has gone up against 2,208 batters in the majors. He has given up 395 hits (6.5 hits per 9 innings) and has 188 free passes. His earned run average is 2.92 (177 earned runs allowed) and his WHIP is 1.067. Ohtani has taken the hill for 546 innings and has accounted for 688 punch outs in his MLB career.

The San Francisco Giants have compiled an OBP of .293 in addition to a team batting average of .251 for the year. They have struck out on 170 occasions (28th in MLB) and have 190 base hits. San Francisco has accounted for 13 long balls so far this season and 71 runs batted in. The Giants have a team slugging % of .365 and they score 3.41 runs per outing (28th in baseball). They have hit 39 doubles, while getting a free base 43 times as well as earning 75 runs.

The San Francisco pitching staff have surrendered 96 runs on the season and come in with a team ERA of 4.15 (90 earned runs allowed). They have conceded 24 dingers and they yield 4.43 runs per 9 innings (13th in baseball). The Giants have a WHIP of 1.323 and have a FIP of 4.12 as a staff on the year. Their strikeout to walk ratio comes in at 9.00 (195 strikeouts against 84 walks). They are sitting at 14th in MLB as a pitching staff in total hits given up with 174.

San Francisco bullpen pitchers have an inherited score percentage of 30.3% out of their 33 inherited base runners. Their bullpen pitchers have stepped onto the mound 9 times in high leverage situations and on 21 occasions with runners on. Sitting with 16 save situations, the Giants have earned 10 holds and 3 blown saves. They sit at 25th in MLB with a save percentage of 50.0%, and they have dispatched 74 relievers onto the diamond so far this season.

The San Francisco Giants have turned 22 double plays and have earned a fielding percentage of .985 (17th in baseball). The Giants have recorded 209 assists, 12 errors and have notched a total of 585 putouts for the year. In 1,755 innings on the diamond, the Giants are sitting with a efficiency on defense of 69.6% (20th in professional baseball).

Thus far in his career, Mahle has given up 705 base knocks while he has totaled 774 strikeouts in 753 innings pitched. He has allowed a total of 347 ER's while holding a WHIP of 1.302 and having a FIP of 4.1. He has a K/BB ratio of 2.80 and he has gone up against 3,210 batters thus far in his career. Mahle (39-49 career record) is the owner of a 4.15 ERA while surrendering 8.4 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Los Angeles (-122)

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