Los Angeles Dodgers vs San Francisco Giants Prediction, 9/25/2026 MLB Picks, Best Bets & Odds

Game: Los Angeles Dodgers vs San Francisco Giants

Date: Friday, September 25, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Los Angeles (-130) San Francisco (+110)

The Los Angeles Dodgers (97-60) are on their way to Oracle Park on Friday where they will try to beat the San Francisco Giants (65-93). The moneyline on this contest has Los Angeles at -130 and San Francisco is sitting at +110. The over/under is set at 8.5. The pitchers expected to start will be Tarik Skubal and Yunior Marte.

Los Angeles has a slugging % of .426 and have been called out on strikes 1,223 times, while taking a walk on 611 occasions. They have accumulated 743 RBI's in addition to 1,358 base knocks so far this season, while their team batting average is at .257. The Dodgers have tallied 259 doubles as a team and have hit 199 balls out of the park. They are sitting with 787 runs scored and have an on-base percentage of .339. As a unit, the Los Angeles Dodgers are scoring 5.0 runs per game, which puts them at 4th in baseball.

Get all of our MLB Parlay Picks

The Dodgers have an earned run average of 3.59 for the season (4th in the league), and they have struck out 1,460 hitters. Dodgers pitchers have yielded 171 home runs and 587 runs (2nd in baseball). Their pitching staff has walked 473 opposing batters and their FIP comes in at 3.76 as a unit on the year. Los Angeles has yielded 1,128 base knocks (7.3 per 9 innings) and also 555 earned runs. They have accrued a K/BB ratio of 3.09 and the pitching staff has a team WHIP of 1.15.

Dodgers pitchers have gone to the mound with runners on 110 times and also have had 166 appearances in high leverage situations. The relief pitchers have recorded 99 holds this season (7th in baseball). The Dodgers relief pitchers have recorded a save percentage of 66.7% and have entered the game in 166 save situations. They have accumulated 44 saves this season and have blown 22 of 66 chances to save the game. The bullpen pitchers have inherited 177 base runners so far this year with 35.0% of those players crossing the plate. The Dodgers have sent 519 relief pitchers to the mound this year.

The Los Angeles Dodgers have notched a total of 4,169 putouts this year, as well as 1,252 assists and 63 errors. Their fielding percentage sits at .989 which ranks 4th in baseball, and have accumulated 87 double plays. The Dodgers have turned 72.1% of balls hit into play into outs out of their 12,507 innings, which ranks them 2nd in pro baseball.

Skubal has thrown 821 innings and has earned 949 K's in his pro baseball career. His earned run average is 3.07 (280 earned runs allowed) and his career WHIP is 1.033. He has surrendered 663 base hits (7.3 hits per 9 innings) and has 185 walks. Skubal (58-39 win-loss record in his career) holds a FIP of 3.02 and he has gone up against 3,279 hitters in the major leagues.

The Giants hold a team slugging % of .404 and they earn 4.20 runs per contest (24th in the league). They have recorded 257 two-baggers, while walking 443 times and scoring 663 runs. San Francisco has accumulated 178 home runs on the year as well as 640 runs batted in. They have been rung up on 1,295 instances (17th in baseball) and are sitting with 1,319 hits. The San Francisco Giants hold a team on-base percentage of .309 and a batting average of .247 over the course of the season.

The Giants have a WHIP of 1.360 in addition to having a FIP of 4.25 as a unit on the year. Their K/BB ratio is 7.60 (1,174 strikeouts vs 583 bases on balls). They are sitting at 19th in baseball as a staff in total hits allowed with 1,312. They have surrendered 154 HR's and they allow 4.81 runs per 9 innings (23rd in baseball). The San Francisco pitching staff have surrendered 745 runs for the season while holding an ERA of 4.36 (675 earned runs conceded).

With 139 save situations, the Giants have earned 83 holds and also 26 blown saves. San Francisco has called on relief pitchers to take the mound in 56 save chances and they have tallied 30 saves. San Francisco bullpen pitchers hold an inherited score percentage of 34.5% out of 281 inherited base runners. Their relief pitchers have come in 137 times in high leverage situations in addition to 180 occasions with runners on. They are ranked 27th in the league holding a save rate of 53.6%, and they have sent 504 relief pitchers onto the field on the season.

The San Francisco Giants have turned 143 double plays and have a fielding percentage of .982 (30th in the majors). The Giants have accrued 1,477 assists, 105 errors and have notched a total of 4,179 putouts so far this year. In 12,537 innings played, the Giants hold a defensive efficiency of 69.6% (15th in professional baseball).

During his pro baseball career, Marte has conceded 131 base hits while totaling 106 K's in 113 frames. He has surrendered 75 ER's while earning a WHIP of 1.643 and being the owner of a FIP of 5.9. He has a K/BB ratio of 1.93 and he has gone up against 529 hitters in his career. Marte (2-2 win-loss mark in his career) holds a 5.96 ERA and has conceded 10.4 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Los Angeles (-130)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.