Los Angeles Dodgers vs San Francisco Giants Prediction, 9/26/2026 MLB Picks, Best Bets & Odds

Game: Los Angeles Dodgers vs San Francisco Giants

Date: Saturday, September 26, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Los Angeles (-145) San Francisco (+125)

The Los Angeles Dodgers (97-62) are hitting the road to Oracle Park on Saturday where they will play the San Francisco Giants (65-94). The odds on this game have Los Angeles at -145 and San Francisco opens at +125. The over/under is set at 9. The pitchers expected to start will be Blake Snell and Matt Wilkinson.

As a squad, the Los Angeles Dodgers are knocking in 5.0 runs per contest, which has them sitting at 4th in baseball. They have accounted for 790 runs while holding a team OBP of .339. The Dodgers have tallied 262 two-baggers as a unit and have hit 199 baseballs out of the stadium. They have accumulated 745 RBI's as well as 1,375 hits for the season, and their batting average is sitting at .257. Los Angeles has a slugging rate of .425 and have struck out 1,243 times, while taking a walk on 618 occasions.

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Their strikeout to walk ratio is 3.10 and their pitching staff has recorded a WHIP of 1.15. Dodgers pitchers have given up 172 home runs and 596 runs in total (2nd in MLB). Los Angeles has surrendered 1,142 base hits (7.3 per 9 innings) as well as 562 earned runs. The Dodgers have a team ERA of 3.59 over the course of the season (4th in baseball), and their staff has struck out 1,481 batters. Their pitching staff has walked 477 batters and their FIP comes in at 3.74 as a unit on the year.

The Dodgers relief pitchers have earned a save percentage of 66.7% and have entered the game in 166 save situations. They have compiled 44 saves over the course of the season and have not converted 22 of their 66 save opportunities. The relief pitchers have inherited 179 base runners so far this season and 35.8% of them ended up crossing the plate. Dodgers bullpen pitchers have stepped onto the hill with runners on base 111 times as well as having 167 appearances in high leverage situations. The Dodgers have sent 525 relievers to the hill this year. The bullpen have earned 99 holds this year (7th in the league).

The Dodgers have converted 72.1% of baseballs in play into outs out of 12,669 innings, which ranks them 2nd in MLB. The Los Angeles Dodgers have accounted for 4,223 putouts on the campaign, in addition to 1,269 assists and 64 errors. Their fielding percentage is holding at .988 which has them sitting 4th in pro baseball, and have 88 double plays.

Snell (85-63 career record) holds a FIP of 3.06 while facing 4,948 opposing hitters during his time in the majors. He has surrendered 917 base knocks (6.9 hits per nine innings) and has 537 free passes. His earned run average is 3.11 (413 ER's allowed) and he has a WHIP of 1.216. Snell has pitched in 1,196 innings and has tallied 1,492 K's so far in his career.

San Francisco has hit 178 HRs over the course of the season as well as 642 RBIs. They have notched 258 doubles, while taking a walk 446 times and scoring 665 runs. The San Francisco Giants have tallied a team OBP of .308 and a batting average of .246 on the campaign. The Giants hold a team SLG% of .403 and they are scoring 4.18 runs per outing (24th in baseball). They have struck out on 1,302 instances (19th in the league) and have recorded 1,324 hits.

The Giants have a team WHIP of 1.360 and are the owners of a FIP of 4.24 as a unit this season. Their K/BB ratio is 7.60 (1,180 strikeouts vs 586 free passes). They have a ranking of 18th in the league as a staff in total hits conceded with 1,321. They have yielded 155 homers and they yield 4.81 runs per 9 innings (23rd in the league). The San Francisco pitching staff have given up 749 runs on the season while holding a team ERA of 4.36 (679 earned runs allowed).

With 139 save situations, the Giants have 83 holds in addition to 26 blown saves. San Francisco has had bullpen pitchers take the mound in 56 save opportunities and they have come away with 30 saves. San Francisco relievers hold an inherited score percentage of 34.6% out of 283 inherited base runners. Their bullpen pitchers have stepped onto the mound 138 times in high leverage situations and on 182 occasions with base runners. They are ranked 27th in baseball with a save percentage of 53.6%, and they have sent 509 relievers onto the diamond this year.

The San Francisco Giants have turned 143 double plays and have notched a fielding percentage of .982 (30th in pro baseball). The Giants have recorded 1,489 assists, 106 errors and have amassed 4,206 putouts so far this season. In their 12,618 innings played, the Giants have a efficiency on defense of 69.6% (15th in baseball).

In his career, Wilkinson has allowed 0 base hits while tallying 0 punch outs in 0 frames. He has conceded 0 earned runs while earning a WHIP of 0.000 and a FIP of 0.0. His strikeout to walk ratio is 0.00 and he has gone up against 0 hitters so far in his career. Wilkinson (0-0 record in his career) has a 0.00 earned run average while surrendering 0.0 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Los Angeles (-145)

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