Miami Marlins vs Chicago Cubs Prediction, 9/22/2026 MLB Picks, Best Bets & Odds

Game: Miami Marlins vs Chicago Cubs

Date: Tuesday, September 22, 2026

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Miami (+102) Chicago (-122)

The Chicago Cubs (87-69) are hosting the Miami Marlins (76-80) at Wrigley Field on Tuesday. The line on this contest has Miami at +102 and Chicago is sitting at -122. The over/under is set at 8.5. The pitchers taking the mound will be Janson Junk and Shota Imanaga.

As a unit, the Miami Marlins are scoring 4.4 runs per outing, which puts them at 17th in MLB. They have tallied 692 runs scored while holding a team OBP of .327. The Marlins have earned 237 doubles as a squad and have knocked 161 balls out of the park. They have earned 662 RBI's in addition to 1,295 hits this season, and their batting average is at .249. Miami has a slugging percentage of .400 and have been called out on strikes 1,296 times, while drawing a walk on 537 occasions.

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The Marlins have an ERA of 4.16 on the year (16th in the league), and their staff has struck out 1,265 batters. Marlins pitchers have given up 167 home runs and also 695 total runs (17th in the league). They have walked 542 batters and their FIP sits at 4.19 as a team so far this season. Miami has allowed 1,229 hits (8.1 per 9 innings) and 634 earned runs. They have earned a strikeout to walk ratio of 2.33 and their pitching staff has earned a collective WHIP of 1.29.

The Marlins relievers have compiled a save rate of 61.1% and have stepped onto the mound in 145 save situations. They have tallied 33 saves for the season and have not converted 21 of 54 save chances. The relievers have inherited 199 runners so far this year and 28.1% of those runners earned a run for their team. Marlins relief pitchers have gone to the mound with runners on 141 times and also have had 153 appearances in high leverage situations. The Marlins have dispatched 520 relievers to the hill on the season. The relievers have a total of 88 holds on the year (11th in the league).

The Marlins have converted 70.5% of balls in play into outs out of their 12,351 innings on the diamond, which has them ranked 11th in professional baseball. The Miami Marlins have notched a total of 4,117 putouts thus far, as well as 1,303 assists and 97 errors. Their fielding percentage is holding at .982 which ranks 28th in MLB, and they have turned 109 double plays.

Junk has thrown 264 innings and is sitting with 189 punch outs thus far in his career. His ERA is 4.70 (138 ER's allowed) and he has a WHIP of 1.322. He has allowed 294 base hits (10.0 hits per 9 innings) and has 55 walks. Junk (13-16 mark in his career) has earned a FIP of 4.63 and he has gone up against 1,123 batters during his time in the major leagues.

Chicago has 217 home runs on the campaign and 790 runs batted in. They have hit 264 doubles, while getting a free base 654 times and racking up 835 runs. The Chicago Cubs have recorded an OBP of .340 and a team batting average of .252 for the season. The Cubs have a team slugging % of .432 and they average 5.35 runs per game (1st in MLB). They have been called out on strikes on 1,294 occasions (16th in the league) and have accounted for 1,350 hits.

The Cubs hold a team WHIP of 1.264 and are the owners of a FIP of 4.64 as a squad on the season. They have earned a strikeout to walk ratio of 7.80 (1,212 strikeouts vs 480 bases on balls). They are currently ranked 17th in the league as a pitching staff in total hits relinquished with 1,279. They have surrendered 228 home runs and they surrender 4.42 runs per 9 innings (12th in baseball). The Chicago pitching staff have given up 683 runs for the season while holding a team ERA of 4.16 (644 earned runs relinquished).

Sitting with 124 save situations, the Cubs have 55 holds and 28 blown saves. Chicago has had bullpen pitchers enter the game in 62 save opportunities and they have converted 34 saves. Chicago relief pitchers have an inherited score rate of 33.6% out of their 223 inherited runners. Their relief pitchers have stepped onto the mound 150 times in high leverage situations and on 158 occasions with runners on base. They rank 26th in baseball with a save percentage of 54.8%, and they have dispatched 498 relief pitchers onto the diamond over the course of the season.

Out of their 12,528 innings played, the Cubs are sitting with a defensive efficiency of 71.9% (3rd in pro baseball). The Chicago Cubs have turned 118 double plays and own a fielding percentage of .990 (1st in MLB). The Cubs have recorded 1,478 assists, 59 errors and are sitting with 4,176 putouts over the course of the season.

In his career, Imanaga has surrendered 415 base knocks while tallying 455 strikeouts in 486 innings. He has given up a total of 187 earned runs while holding a WHIP of 1.041 and having a FIP of 3.4. He has a strikeout to walk ratio of 5.00 and he has gone up against 1,944 opposing hitters so far in his career. Imanaga (35-21 career mark) is the owner of a 3.46 ERA and has given up 7.7 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Miami (+102)

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