Milwaukee Brewers vs Detroit Tigers Prediction, 4/21/2026 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs Detroit Tigers

Date: Tuesday, April 21, 2026

Location: Comerica Park in Detroit, MI

TV: Detroit SportsNet

Odds/Point Spread: Milwaukee (-122) Detroit (+102)

The Milwaukee Brewers (12-9) are traveling to Comerica Park on Tuesday where they will attempt to defeat the Detroit Tigers (12-10). The line on this contest has Milwaukee at -122 while Detroit is priced at +102. The over/under has been set at 8. The expected starting pitchers are Kyle Harrison and Keider Montero.

The Brewers have hit 32 two-baggers as a unit and have hit 19 baseballs out of the park. Milwaukee has a slugging % of .366 and have been called out on strikes 178 times, while being walked on 109 occasions. As a team, the Milwaukee Brewers are compiling 5.1 runs per contest, which ranks them 8th in baseball. They have 101 RBI's in addition to 161 base knocks so far this year, while their batting average is at .232. They have earned 106 runs while holding a team on-base percentage of .339.

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They have earned a strikeout to walk ratio of 2.36 and the pitching staff holds a collective WHIP of 1.32. Brewers pitchers have relinquished 18 home runs and 87 runs (10th in the league). Milwaukee has allowed 167 hits (8.0 per 9 innings) and 80 earned runs. The Brewers have compiled a team ERA of 3.85 so far this year (11th in the league), and they have struck out 189 batters. They have walked 80 opposing batters and their FIP is 3.77 as a squad this year.

The Brewers relief pitchers have accumulated a save rate of 66.7% and stepped onto the hill in 26 save situations. They have recorded 8 saves on the year and have missed out on 4 out of their 12 save opportunities. The relief pitchers have inherited 34 runners over the course of the season and 41.2% of those players ended up crossing the plate. Brewers bullpen pitchers have entered the contest with runners on 21 times and also have had 25 appearances in high leverage situations. The Brewers have dispatched 73 relievers to the mound for the year. The bullpen have 14 holds so far this season (13th in MLB).

The Miami Marlins are sitting with 561 putouts this season, in addition to 184 assists and 8 errors. Their fielding rate is holding steady at .989 which is 7th in baseball, and have 14 double plays. The Brewers have transformed 69.2% of balls hit into play into outs out of their 1,683 innings on the field, which has them sitting at 22nd in professional baseball.

Harrison (10-10 career record) has earned a FIP of 4.25 while he has gone up against 895 opposing hitters in the major leagues. He has surrendered 201 base knocks (8.7 hits per nine innings) and has had 71 free passes. His earned run average is 4.32 (100 earned runs allowed) and he has a career WHIP of 1.305. Harrison has taken the mound for 208 innings and has earned 206 punch outs in his MLB career.

Detroit has a total of 17 home runs this year to go along with 90 runs batted in. They have put up 42 two-baggers, while getting a free base 80 times as well as earning 94 runs. The Detroit Tigers have accounted for an on-base percentage of .324 in addition to a team batting average of .243 on the campaign. The Tigers have a team slugging % of .380 and they score 4.27 runs per contest (16th in MLB). They have been called out on strikes on 180 occasions (17th in MLB) and have accounted for 176 base hits.

The Tigers have a WHIP of 1.216 and have a FIP of 3.48 as a team for the season. They rank 4th in baseball as a staff in total hits relinquished with 155. The Detroit pitching staff have conceded 75 runs for the year and come in with a team ERA of 3.28 (69 earned runs given up). Their strikeout to walk ratio comes in at 8.40 (176 strikeouts vs 75 bases on balls). They have conceded 13 dingers and they relinquish 3.57 runs per 9 innings (3rd in MLB).

They sit at 7th in the league with a save rate of 75.0%, and they have dispatched 60 bullpen pitchers onto the field for the season. Their bullpen pitchers have taken the field 15 times in high leverage situations and on 26 occasions with runners on base. Sitting with 18 save situations, the Tigers have amassed 9 holds in addition to 2 blown saves. Detroit has called on bullpen pitchers to take the mound in 8 save opportunities and they have recorded 6 saves. Detroit relievers hold an inherited score rate of 37.2% out of 43 inherited runners.

In 1,707 innings played, the Tigers hold a defensive efficiency of 71.2% (10th in pro baseball). The Detroit Tigers have gotten 19 double plays and have notched a fielding percentage of .984 (20th in the majors). The Tigers have 180 assists, 12 errors and have accounted for 569 putouts so far this year.

In his MLB career, Montero has surrendered 207 base knocks while earning 164 punch outs in 205 innings pitched. He has allowed 102 earned runs while holding a WHIP of 1.321 and having a FIP of 4.4. He has a strikeout to walk ratio of 2.56 and he has gone up against 864 hitters in his career. Montero (12-10 record in his career) has earned a 4.48 ERA while surrendering 9.1 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Detroit (+102) and under 8 runs

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