Milwaukee Brewers vs Detroit Tigers Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs Detroit Tigers

Date: Wednesday, April 22, 2026

Location: Comerica Park in Detroit, MI

TV: Detroit SportsNet

Odds/Point Spread: Milwaukee (-152) Detroit (+126)

The Milwaukee Brewers (12-9) are on their way to Comerica Park on Wednesday where they will try to defeat the Detroit Tigers (12-11). The moneyline on this game has Milwaukee at -152 while Detroit is sitting at +126. The over/under comes in at 8. The pitchers expected to start will be Chad Patrick and Casey Mize.

Milwaukee has a slugging rate of .366 and have struck out 178 times, while being walked on 109 occasions. They have compiled 101 RBI's and 161 base knocks over the course of the season, and their batting average comes in at .232. The Brewers have tallied 32 two-baggers as a team and have smacked 19 baseballs out of the park. They are sitting with 106 runs and have an OBP of .339. As a team, the Milwaukee Brewers are scoring 5.1 runs per game, which puts them at 8th in MLB.

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The Brewers are sitting with a team ERA of 3.85 on the season (12th in baseball), and their staff has rung up 189 batters. Brewers pitchers have conceded 18 long balls and 87 total runs (9th in MLB). They have walked 80 players from the other team and their FIP comes in at 3.77 as a team this year. Milwaukee has conceded 167 base hits (8.0 per 9 innings) as well as 80 earned runs. They have a K/BB ratio of 2.36 and their pitching staff has earned a collective WHIP of 1.32.

The Brewers have sent 73 relief pitchers to the hill this year. The bullpen pitchers have inherited 34 runners so far this year and 41.2% of those runners crossing the plate. The bullpen have a total of 14 holds over the course of the season (14th in MLB). Brewers bullpen pitchers have stepped onto the hill with players on base 21 times in addition to having 25 appearances in high leverage situations. They have earned 8 saves on the year and have missed out on 4 of their 12 chances to get a save. The Brewers relievers have compiled a save rate of 66.7% and have come into the game in 26 save situations.

The Brewers have converted 69.2% of balls hit into play into outs out of 1,683 innings, which has them ranked 21st in pro baseball. The Miami Marlins have earned 561 putouts this season, as well as 184 assists and 8 errors. Their fielding percentage is at .989 which ranks 7th in MLB, and have a total of 14 double plays.

Patrick has taken the hill for 138 frames and has 136 punch outs during his pro baseball career. Patrick (4-8 record in his career) has earned a FIP of 3.14 while he has faced 578 opposing hitters during his time in the majors. His earned run average is 3.19 (49 ER's allowed) and he has a career WHIP of 1.266. He has surrendered 128 hits (8.3 hits per nine innings) and has had 47 walks.

The Tigers have a team slugging percentage of .381 and they have an average of 4.35 runs per contest (16th in MLB). They have hit 46 doubles, while taking a walk 84 times and recording 100 runs. Detroit has knocked in 17 HRs over the course of the season to go along with 96 RBIs. They have been called out on strikes on 187 instances (16th in the league) and have a total of 186 hits. The Detroit Tigers are sitting with a team on-base percentage of .326 and a batting average of .245 for the year.

The Tigers hold a team WHIP of 1.268 and have a FIP of 3.52 as a unit this season. They are sitting at 5th in the league as a staff in total hits conceded with 167. The Detroit pitching staff have conceded 83 runs so far this year while having a team ERA of 3.42 (75 earned runs surrendered). Their strikeout to walk ratio comes in at 8.30 (183 strikeouts vs 83 walks). They have allowed 13 long balls and they relinquish 3.79 runs per 9 innings (6th in MLB).

Detroit relievers have an inherited score percentage of 34.0% of 47 inherited runners. Their relievers have stepped onto the hill 17 times in high leverage situations and on 28 occasions with runners on. With 18 save situations, the Tigers have accumulated 9 holds and 2 blown saves. They are ranked 7th in MLB holding a save rate of 75.0%, and they have dispatched 63 relievers to the mound so far this year.

The Detroit Tigers have turned 19 double plays and have a fielding percentage of .984 (20th in baseball). The Tigers have accrued 185 assists, 13 errors and have a total of 593 putouts on the campaign. In their 1,779 innings on the diamond, the Tigers have earned a defensive efficiency of 70.5% (14th in pro baseball).

So far in his MLB career, Mize has surrendered 466 base hits while he has earned 390 K's in 462 frames. He has given up 212 earned runs while holding a WHIP of 1.285 and being the owner of a FIP of 4.1. He has a strikeout to walk ratio of 3.05 and he has faced 1,963 hitters thus far in his career. Mize (24-26 career win-loss mark) holds a 4.13 ERA while surrendering 9.1 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Milwaukee (-152)

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