Milwaukee Brewers vs Philadelphia Phillies Prediction, 9/22/2026 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs Philadelphia Phillies

Date: Tuesday, September 22, 2026

Location: Citizens Bank Park in Philadelphia, PA

TV: NBC Sports Philadelphia

Odds/Point Spread: Milwaukee (-132) Philadelphia (+110)

The Milwaukee Brewers (98-58) are hitting the road to Citizens Bank Park on Tuesday where they will take on the Philadelphia Phillies (86-70). The moneyline on this contest has Milwaukee at -132 while Philadelphia opens at +110. The betting total comes in at 8.5. The men taking the mound are Dustin May and Zack Wheeler.

The Brewers have accrued 270 doubles as a squad and have hit 149 balls out of the stadium. Milwaukee has a slugging % of .403 and have struck out 1,323 times, while drawing a walk on 648 occasions. As a team, the Milwaukee Brewers are scoring 5.1 runs per game, which has them at 2nd in the league. They have recorded 758 runs batted in in addition to 1,369 hits for the year, while their team batting average is sitting at .258. They are sitting with 802 runs scored and hold an on-base percentage of .341.

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Their strikeout to walk ratio sits at 2.98 and their pitching staff has a collective WHIP of 1.19. Brewers pitchers have surrendered 165 home runs and 600 runs in total (4th in baseball). Milwaukee has surrendered 1,155 base knocks (7.5 per 9 innings) and also 548 earned runs. The Brewers are sitting with a team ERA of 3.54 this year (2nd in the league), and they have rung up 1,492 hitters. They have walked 500 opposing players and their FIP comes in at 3.71 as a team over the course of the season.

Brewers bullpen pitchers have gone to the mound with opponents on base 127 times as well as having 155 appearances in high leverage situations. The relief pitchers have racked up 82 holds for the season (18th in baseball). The Brewers relievers have compiled a save rate of 71.8% and have stepped onto the mound in 155 save situations. They have compiled 51 saves on the campaign and have blown 20 of 71 save chances. The relief pitchers have inherited 185 runners so far this year with 37.8% of those runners ended up crossing the plate. The Brewers have sent 490 relievers to the mound for the year.

The Brewers have converted 71.0% of balls in play into outs out of their 12,543 innings, which has them ranked 8th in professional baseball. The Milwaukee Brewers have a tally of 4,181 putouts this year, in addition to 1,224 assists and 68 errors. Their fielding percentage is holding at .988 which is 7th in pro baseball, and have 116 double plays.

May has taken the hill for 355 innings and has totaled 328 strikeouts so far in his pro baseball career. May (21-22 win-loss mark in his career) has a FIP of 3.94 and he has gone up against 1,496 hitters in the major leagues. His ERA is 4.00 (158 ER's allowed) and his career WHIP is 1.222. He has allowed 309 base hits (7.8 hits per 9 innings) with 125 free passes.

The Phillies hold a team slugging % of .397 and they score 4.47 runs per contest (14th in baseball). They have hit 232 two-baggers, while taking a walk 506 times and recording 697 runs. Philadelphia has accumulated 179 home runs so far this year as well as 677 runs batted in. They have been called out on strikes on 1,282 occasions (18th in baseball) and have tallied 1,260 base hits. The Philadelphia Phillies have tallied an OBP of .312 in addition to a team batting average of .241 this year.

The Phillies hold a team WHIP of 1.286 and are the owners of a FIP of 3.81 as a squad this year. Their K/BB ratio is 9.80 (1,510 strikeouts against 468 walks). They sit at 21st in the league as a staff in total hits given up with 1,312. They have yielded 184 dingers and they allow 4.34 runs per 9 innings (10th in MLB). The Philadelphia pitching staff have surrendered 668 runs on the campaign while having a team ERA of 4.01 (616 earned runs allowed).

Philadelphia relievers have an inherited score percentage of 37.7% out of 162 inherited runners. Their relief pitchers have stepped onto the mound 153 times in high leverage situations in addition to 117 occasions with base runners. Sitting with 139 save situations, the Phillies have earned 73 holds in addition to 23 blown saves. They are ranked 15th in MLB with a save percentage of 64.1%, and they have dispatched 510 relief pitchers onto the field this year.

The Philadelphia Phillies have turned 101 double plays and have accounted for a fielding rate of .986 (14th in MLB). The Phillies have accrued 1,290 assists, 77 errors and are sitting with 4,153 putouts on the season. In their 12,459 innings on the diamond, the Phillies have accumulated a defensive efficiency of 67.9% (28th in baseball).

So far in his MLB career, Wheeler has given up 1,588 base knocks while accumulating 1,997 strikeouts in 1,878 frames. He has given up a total of 680 ER's while earning a WHIP of 1.131 and a FIP of 3.2. He has a strikeout to walk ratio of 3.73 and he has gone up against 7,685 hitters thus far in his career. Wheeler (126-80 career mark) is the owner of a 3.26 ERA while allowing 7.6 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Philadelphia (+110) and under 8.5 runs

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