Milwaukee Brewers vs Pittsburgh Pirates Prediction, 9/16/2026 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs Pittsburgh Pirates

Date: Wednesday, September 16, 2026

Location: PNC Park in Pittsburgh, PA

TV: SportsNet Pittsburgh

Odds/Point Spread: Milwaukee (-144) Pittsburgh (+120)

PNC Park is the location where the Pittsburgh Pirates (75-75) will take on the Milwaukee Brewers (93-57) on Wednesday. The moneyline on this matchup has the Brewers at -144 and the Pirates are at +120. The betting total comes in at 9. The pitchers who are expected to start are Logan Henderson and Jared Jones.

As a unit, the Milwaukee Brewers are earning 5.2 runs per game, which has them at 2nd in MLB. They have 778 runs and hold an OBP of .341. The Brewers have accrued 261 doubles as a unit and have hit 146 balls out of the park. They have amassed 735 RBI's and 1,323 base knocks so far this year, and their average at the plate is sitting at .259. Milwaukee has a slugging % of .406 and have struck out 1,259 times, while being walked on 620 occasions.

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They have earned a K/BB ratio of 2.97 and the pitching staff holds a collective WHIP of 1.19. Brewers pitchers have conceded 159 home runs and also 583 runs (4th in the league). Milwaukee has given up 1,106 base hits (7.4 per 9 innings) and 532 earned runs. The Brewers have a team earned run average of 3.57 on the campaign (2nd in baseball), and they have struck out 1,433 batters. Their pitching staff has walked 483 opposing batters and their FIP sits at 3.72 as a team over the course of the season.

The Brewers have sent 464 relief pitchers to the mound on the year. The relievers have inherited 173 base runners this season and 40.5% of them crossing home plate. The bullpen have a total of 76 holds this year (21st in MLB). Brewers relief pitchers have entered the contest with runners on 119 times and also have had 145 appearances in high leverage situations. They have accumulated 47 saves on the season and have not converted 19 of their 66 chances to save the game. The Brewers relievers have recorded a save percentage of 71.2% and have come into the game in 143 save situations.

The Milwaukee Brewers have a tally of 4,019 putouts so far this season, in addition to 1,173 assists and 67 errors. Their fielding rate is currently at .987 which has them ranked 10th in the majors, and have a total of 112 double plays. The Brewers have transformed 71.0% of balls in play into outs out of 12,057 innings on the field, ranking them 8th in the majors.

Henderson (13-3 win-loss mark in his career) has a FIP of 2.19 and he has gone up against 427 hitters in the majors. He has conceded 71 hits (5.6 hits per nine innings) with 23 walks. His ERA is 2.23 (28 ER's allowed) and he has a career WHIP of 0.830. Henderson has taken the ball for 113 innings and is sitting with 132 punch outs thus far in his career.

The Pittsburgh Pirates have an OBP of .330 as well as a team batting average of .253 on the season. They have been called out on strikes on 1,395 occasions (4th in baseball) and are sitting with 1,302 base hits. Pittsburgh has hit 170 long balls on the campaign to go along with 685 runs batted in. The Pirates hold a team slugging % of .401 and they have an average of 4.79 runs per game (5th in the league). They have notched 224 doubles, while taking a walk 533 times and scoring 718 runs.

The Pirates have a team WHIP of 1.299 in addition to having a FIP of 3.87 as a team on the season. They currently have a strikeout to walk ratio of 9.20 (1,369 strikeouts against 543 bases on balls). They sit at 12th in the league as a staff in total hits surrendered with 1,195. They have conceded 145 HR's and they allow 4.65 runs per 9 innings (21st in baseball). The Pittsburgh pitching staff have allowed 692 runs so far this year while holding a team ERA of 4.18 (621 earned runs yielded).

Pittsburgh relievers hold an inherited score percentage of 31.7% out of their 183 inherited base runners. Their relief pitchers have stepped onto the mound 144 times in high leverage situations and on 124 occasions with runners on base. With 130 save situations, the Pirates have tallied 71 holds and also 23 blown saves. They are ranked 21st in MLB with a save rate of 59.6%, and they have sent 485 relievers to the hill this year.

The Pittsburgh Pirates have gotten 124 double plays and have notched a fielding percentage of .983 (26th in professional baseball). The Pirates have recorded 1,192 assists, 92 errors and have a tally of 4,015 putouts on the campaign. In their 12,045 innings played, the Pirates are sitting with a defensive efficiency of 69.1% (26th in pro baseball).

So far in his MLB career, Jones has conceded 176 hits while earning 232 K's in 206 innings. Jones (10-14 career win-loss mark) holds a 4.14 ERA while giving up 7.7 hits per 9 innings. He has given up a total of 95 earned runs while holding a WHIP of 1.187 and being the owner of a FIP of 4.1. He has a K/BB ratio of 3.36 and he has gone up against 861 hitters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Milwaukee (-144)

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