Milwaukee Brewers vs St. Louis Cardinals Prediction, 5/6/2026 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs St. Louis Cardinals

Date: Wednesday, May 6, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Milwaukee (-145) St. Louis (+125)

The St. Louis Cardinals (21-14) will try to defeat the Milwaukee Brewers (18-16) at Busch Stadium on Wednesday. The moneyline on this contest has Milwaukee at -145 while St. Louis opens at +125. The betting total comes in at 8. The men taking the mound will be Jacob Misiorowski and Matthew Liberatore.

The Brewers have hit 56 two-baggers as a team and have knocked 23 baseballs out of the stadium. Milwaukee has a slugging percentage of .358 and have been called out on strikes 269 times, while being walked on 159 occasions. As a team, the Milwaukee Brewers are earning 5.2 runs/g, which puts them at 5th in MLB. They have compiled 168 RBI's as well as 275 hits this year, and their average at the plate is .241. They have tallied 175 runs scored and have an on-base percentage of .336.

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The Brewers have compiled a team ERA of 3.64 so far this year (4th in baseball), and their staff has rung up 318 batters. Brewers pitchers have yielded 28 home runs and also 133 total runs (5th in baseball). Their pitching staff has walked 122 opposing hitters and their FIP sits at 3.56 as a team on the campaign. Milwaukee has given up 261 base hits (7.8 per 9 innings) as well as 122 earned runs. They have earned a K/BB ratio of 2.61 and the pitching staff has a collective WHIP of 1.27.

The Brewers have sent 114 relief pitchers to the hill so far this season. The bullpen pitchers have inherited 51 runners this season and 37.3% of them ended up scoring. The relief pitchers have recorded 20 holds this season (16th in the league). Brewers pitchers have come into the game with runners on 33 times as well as having 35 appearances in high leverage situations. They have recorded 10 saves for the year and have blown 5 of their 15 chances to get a save. The Brewers relievers have a save rate of 66.7% and have stepped onto the mound in 36 save situations.

The Milwaukee Brewers have 904 putouts at this point in the season, in addition to 279 assists and 16 errors. Their fielding rate is holding steady at .987 which is 10th in pro baseball, and have accumulated 27 double plays. The Brewers have transformed 69.1% of baseballs in play into outs out of 2,712 innings on the field, which has them sitting at 22nd in MLB.

Misiorowski has thrown 104 innings and is sitting with 146 punch outs during his MLB career. Misiorowski (7-5 record in his career) holds a FIP of 3.75 and he has gone up against 428 batters in the major leagues. His earned run average is 3.81 (44 ER's allowed) and his WHIP is 1.154. He has conceded 74 base hits (6.4 hits per nine innings) with 46 free passes.

The St. Louis Cardinals are sitting with an OBP of .327 as well as a team batting average of .243 this year. They have struck out on 292 instances (15th in MLB) and have earned a total of 286 hits. St. Louis has 44 home runs on the year to go along with 168 RBIs. The Cardinals hold a team slugging percentage of .404 and they are scoring 4.91 runs per game (9th in the league). They have 55 doubles, while getting a free base 127 times as well as putting up 172 runs.

The Cardinals have a WHIP of 1.427 and are the owners of a FIP of 4.62 as a pitching staff over the course of the season. Their K/BB ratio is 6.90 (243 strikeouts vs 134 walks). They come in at 25th in baseball as a pitching staff in total hits conceded with 317. They have allowed 38 home runs and they concede 4.81 runs per 9 innings (21st in baseball). The St. Louis pitching staff have allowed 169 runs over the course of the season while holding an ERA of 4.50 (158 earned runs relinquished).

They rank 8th in the league with a save percentage of 68.4%, and they have dispatched 129 relievers onto the field on the year. Their relief pitchers have stepped onto the hill 45 times in high leverage situations and on 40 occasions with base runners. Sitting with 51 save situations, the Cardinals have earned 30 holds and 6 blown saves. St. Louis has had relievers take the mound in 19 save opportunities and they have tallied 13 saves. St. Louis relievers have an inherited score rate of 38.3% of 60 inherited runners.

In 2,844 innings on the field, the Cardinals are sitting with a efficiency on defense of 69.2% (20th in pro baseball). The St. Louis Cardinals have gotten 36 double plays and have accounted for a fielding rate of .986 (14th in pro baseball). The Cardinals have recorded 355 assists, 18 errors and have a total of 948 putouts during this campaign.

Liberatore (17-25 career win-loss mark) has earned a 4.62 ERA while giving up 9.4 hits per 9 innings. He has a strikeout to walk ratio of 2.38 and he has gone up against 1,600 opposing hitters thus far in his career. He has allowed a total of 190 ER's while holding a WHIP of 1.384 and a FIP of 4.6. In his career, Liberatore has conceded 388 base knocks while earning 295 punch outs in 370 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+125)

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