Minnesota Twins vs Boston Red Sox Prediction, 5/22/2026 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs Boston Red Sox

Date: Friday, May 22, 2026

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: Minnesota (+102) Boston (-122)

The Boston Red Sox (22-27) welcome the Minnesota Twins (23-27) at Fenway Park on Friday. The line on this contest has the Twins at +102 while the Red Sox are coming in at -122. The betting total is set at 9. The pitchers taking the mound are Connor Prielipp and Payton Tolle.

As a unit, the Minnesota Twins are compiling 4.6 runs per contest, which ranks them 10th in MLB. They have tallied 230 runs scored and have an OBP of .322. The Twins have compiled 74 two-baggers as a team and have hit 55 baseballs out of the stadium. They have amassed 217 runs batted in and 391 hits this season, and their team batting average is .236. Minnesota has a slugging % of .387 and have been called out on strikes 429 times, while taking a walk on 185 occasions.

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They have earned a strikeout to walk ratio of 2.16 and their pitching staff has recorded a WHIP of 1.32. Twins pitchers have given up 44 home runs and 231 total runs (23rd in baseball). Minnesota has given up 404 hits (8.2 per 9 innings) and 206 earned runs. The Twins are sitting with a team earned run average of 4.20 on the year (17th in the league), and their staff has struck out 382 hitters. They have walked 177 players from the other team and their FIP is 4.08 as a team so far this year.

Twins relief pitchers have entered the game with runners on 54 times in addition to having 46 appearances in high leverage situations. The relief pitchers have accumulated 33 holds on the season (6th in MLB). The Twins relief pitchers have a save percentage of 64.7% and have entered the game in 51 save situations. They have earned 11 saves on the campaign and have blown 6 of their 17 chances to get a save. The bullpen pitchers have inherited 79 runners over the course of the season with 34.2% of them crossing home plate. The Twins have sent 165 relievers to the mound so far this year.

The Minnesota Twins have accounted for 1,323 putouts on the year, as well as 373 assists and 24 errors. Their fielding rate sits at .986 which puts them in 19th in baseball, and have accumulated 37 double plays. The Twins have turned 70.3% of balls in play into outs out of 3,969 innings on the diamond, ranking them 14th in pro baseball.

Prielipp (1-2 record in his career) has earned a FIP of 2.84 while he has faced 102 hitters in the majors. He has conceded 15 base knocks (5.4 hits per nine innings) and has 9 free passes. His earned run average is 2.88 (8 earned runs allowed) and his career WHIP is 0.960. Prielipp has taken the ball for 25 frames and is sitting with 29 strikeouts in his MLB career.

The Red Sox hold a team SLG% of .366 and they have an average of 3.69 runs per contest (29th in baseball). They have tallied 84 doubles, while taking a walk 150 times and earning 181 runs. Boston has knocked in 36 home runs on the campaign as well as 173 runs batted in. They have been rung up on 411 occasions (17th in baseball) and have earned 395 base hits. The Boston Red Sox have an OBP of .314 and a team batting average of .240 so far this year.

The Boston pitching staff have yielded 192 runs so far this year while having an ERA of 3.68 (177 earned runs conceded). They have conceded 57 homers and they allow 3.99 runs per 9 innings (8th in the league). The Red Sox are sitting with a team WHIP of 1.228 in addition to having a FIP of 4.16 as a unit for the season. Their strikeout to walk ratio sits at 8.30 (401 strikeouts against 152 free passes). They have a ranking of 10th in MLB as a staff in total hits given up with 380.

Sitting with 44 save situations, the Red Sox have tallied 27 holds in addition to 4 blown saves. Boston has had bullpen pitchers step onto the hill in 16 save chances and they have earned 12 saves. Boston bullpen pitchers hold an inherited score percentage of 28.8% out of 59 inherited runners. Their bullpen pitchers have taken the field 48 times in high leverage situations in addition to 43 occasions with runners on base. They are ranked 4th in MLB holding a save rate of 75.0%, and they have dispatched 151 relievers to the hill for the season.

The Boston Red Sox have gotten 33 double plays and have a fielding rate of .987 (14th in MLB). The Red Sox have racked up 436 assists, 23 errors and have earned 1,300 putouts on the season. In 3,900 innings played, the Red Sox hold a efficiency on defense of 71.4% (7th in the majors).

So far in his career, Tolle has conceded 35 hits while he has totaled 49 punch outs in 46 innings. He has given up 18 earned runs while holding a WHIP of 1.080 and a FIP of 3.4. His strikeout to walk ratio is 3.27 and he has faced 189 hitters in his MLB career. Tolle (2-3 record in his career) has earned a 3.50 ERA while allowing 6.8 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Boston (-122)

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