Minnesota Twins vs Chicago White Sox Prediction, 5/25/2026 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs Chicago White Sox

Date: Monday, May 25, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Minnesota (-122) Chicago (+102)

Rate Field is the location where the Chicago White Sox (26-25) will meet the Minnesota Twins (25-27) on Monday. The line on this matchup has the Twins at -122 and the White Sox are at +102. The total is set at 8.5. The starting pitchers will be Zebby Matthews and Anthony Kay.

The Twins have tallied 78 two-baggers as a squad and have smacked 57 balls out of the stadium. Minnesota has a slugging rate of .389 and have been called out on strikes 449 times, while drawing a walk on 190 occasions. As a team, the Minnesota Twins are putting up 4.7 runs/g, which is 9th in the league. They have compiled 229 RBI's in addition to 413 hits on the year, and their average at the plate is at .238. They are sitting with 242 runs scored and hold an OBP of .323.

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They have accumulated a K/BB ratio of 2.13 and the pitching staff has a collective WHIP of 1.32. Twins pitchers have conceded 44 long balls in addition to 239 total runs (22nd in baseball). Minnesota has relinquished 416 base hits (8.2 per 9 innings) and 213 earned runs. The Twins are sitting with a team earned run average of 4.18 so far this year (19th in the league), and the staff has struck out 400 batters. Their pitching staff has walked 188 opposing players and their FIP is 4.02 as a team over the course of the season.

The Twins have dispatched 172 relievers to the mound so far this year. The relief pitchers have inherited 84 runners on the campaign with 32.1% of those players earned a run for their team. The bullpen are sitting with 37 holds for the season (5th in the league). Twins pitchers have entered the game with runners on base 56 times in addition to having 50 appearances in high leverage situations. They have accumulated 13 saves over the course of the season and have blown 6 of their 19 chances to get a save. The Twins relievers have accumulated a save percentage of 68.4% and have come into the game in 57 save situations.

The Twins have transformed 70.3% of balls in play into outs out of 4,131 innings on the diamond, which has them ranked 17th in the majors. The Minnesota Twins are sitting with 1,377 putouts this season, as well as 391 assists and 27 errors. Their fielding percentage is at .985 which ranks 20th in professional baseball, and have a total of 40 double plays.

Matthews has thrown 130 innings and has totaled 142 strikeouts thus far in his career. Matthews (7-11 win-loss record in his career) sits with a FIP of 5.39 and he has gone up against 579 hitters during his time in the majors. His earned run average is 5.47 (79 ER's allowed) and his WHIP is 1.462. He has conceded 154 base hits (10.7 hits per nine innings) with 36 free passes.

The Chicago White Sox hold an OBP of .323 and a batting average of .234 for the season. They have struck out on 477 instances (4th in MLB) and have recorded 393 base hits. Chicago has hit 68 long balls over the course of the season as well as 218 runs batted in. The White Sox have a team slugging % of .399 and they have an average of 4.51 runs per game (12th in the league). They have recorded 62 doubles, while taking a walk 192 times and putting up 230 runs.

The White Sox have a team WHIP of 1.365 in addition to having a FIP of 4.46 as a pitching staff on the season. They rank 12th in baseball as a staff in total hits given up with 409. The Chicago pitching staff have conceded 244 runs on the season while having an ERA of 4.47 (224 earned runs surrendered). Their K/BB ratio is 8.20 (413 strikeouts vs 207 bases on balls). They have conceded 56 dingers and they yield 4.87 runs per 9 innings (24th in baseball).

Sitting with 43 save situations, the White Sox have accrued 16 holds and also 11 blown saves. Chicago has had relievers enter the contest in 27 save chances and they have earned 16 saves. Chicago relievers have an inherited score rate of 33.3% of 90 inherited base runners. Their relief pitchers have come in 50 times in high leverage situations in addition to 59 occasions with base runners. They rank 19th in baseball holding a save percentage of 59.3%, and they have dispatched 177 bullpen pitchers onto the field on the year.

Out of their 4,065 innings on the diamond, the White Sox have earned a defensive efficiency of 70.6% (13th in MLB). The Chicago White Sox have turned 36 double plays and have a fielding rate of .986 (18th in MLB). The White Sox have recorded 448 assists, 26 errors and have accumulated 1,355 putouts over the course of the season.

So far in his career, Kay has conceded 135 hits while totaling 122 K's in 131 frames. Kay (7-3 career mark) is the owner of a 5.14 ERA while surrendering 9.3 hits per nine innings. He has allowed a total of 75 earned runs while holding a WHIP of 1.555 and a FIP of 5.1. He has a strikeout to walk ratio of 1.77 and he has gone up against 605 batters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+102)

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