Minnesota Twins vs Chicago White Sox Prediction, 5/26/2026 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs Chicago White Sox

Date: Tuesday, May 26, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Minnesota (-144) Chicago (+120)

Rate Field is where the Chicago White Sox (27-26) will go up against the Minnesota Twins (26-28) on Tuesday. The moneyline on this game has the Twins at -144 and the White Sox are at +120. The betting total is set at 9. The pitchers expected to start will be Joe Ryan and Sean Burke.

As a squad, the Minnesota Twins are notching 4.7 runs per game, which ranks them 9th in MLB. They have notched a total of 248 runs scored while holding a team on-base percentage of .325. The Twins have accumulated 81 two-baggers as a team and have smacked 57 baseballs out of the park. They have tallied 234 runs batted in as well as 425 base knocks for the year, and their team batting average is .240. Minnesota has a slugging % of .389 and have been rung up 461 times, while being walked on 195 occasions.

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They have accrued a K/BB ratio of 2.15 and their pitching staff has recorded a WHIP of 1.32. Twins pitchers have given up 46 home runs and also 244 runs (23rd in baseball). Minnesota has allowed 427 hits (8.2 per 9 innings) in addition to 218 earned runs. The Twins have an ERA of 4.19 on the season (20th in baseball), and the staff has struck out 407 batters. They have walked 189 opposing players and their FIP is 4.03 as a team so far this year.

Twins bullpen pitchers have come into the game with runners on 59 times and also have had 55 appearances in high leverage situations. The relievers have earned 41 holds on the year (3rd in MLB). The Twins bullpen have recorded a save percentage of 70.0% and have come into the game in 62 save situations. They have tallied 14 saves for the year and have blown 6 of their 20 chances to save the game. The relievers have inherited 89 runners so far this year with 30.3% of those players ended up crossing the plate. The Twins have sent 177 relievers to the hill for the season.

The Twins have turned 70.2% of balls hit into play into outs in their 4,212 innings, which has them sitting at 18th in professional baseball. The Minnesota Twins have earned 1,404 putouts for the season, as well as 398 assists and 28 errors. Their fielding percentage is currently at .985 which has them sitting 23rd in pro baseball, and they have turned 41 double plays.

Ryan (49-39 career win-loss record) sits with a FIP of 3.67 and he has faced 2,828 batters during his time in the major leagues. He has conceded 575 hits (7.4 hits per nine innings) and has 162 walks. His earned run average is 3.73 (289 ER's allowed) and he has a WHIP of 1.057. Ryan has thrown 697 frames and has totaled 780 strikeouts thus far in his career.

The White Sox have a team slugging % of .399 and they average 4.52 runs per game (12th in the league). They have hit 63 doubles, while getting a free base 200 times and putting up 235 runs. Chicago has tallied 70 home runs on the year to go along with 223 runs batted in. They have struck out on 485 occasions (5th in the league) and have 397 base hits. The Chicago White Sox hold a team on-base percentage of .322 in addition to a team batting average of .232 over the course of the season.

The Chicago pitching staff have allowed 252 runs this season while having a team ERA of 4.55 (232 earned runs yielded). They have conceded 58 home runs and they concede 4.94 runs per 9 innings (24th in MLB). The White Sox hold a team WHIP of 1.370 with a FIP of 4.49 as a staff this year. They currently have a K/BB ratio of 8.20 (419 strikeouts against 209 free passes). They sit at 16th in baseball as a staff in total hits given up with 420.

Chicago relief pitchers have an inherited score percentage of 34.8% of 92 inherited runners. Their bullpen pitchers have come in 51 times in high leverage situations and on 60 occasions with runners on base. Sitting with 43 save situations, the White Sox have 16 holds and 11 blown saves. They rank 19th in the league with a save percentage of 59.3%, and they have dispatched 181 relievers to the hill for the year.

In 4,137 innings on the field, the White Sox have a defensive efficiency of 70.4% (16th in the majors). The Chicago White Sox have gotten 36 double plays and have notched a fielding percentage of .986 (18th in baseball). The White Sox have racked up 459 assists, 27 errors and have a tally of 1,379 putouts so far this season.

Burke (8-14 mark in his career) has earned a 3.93 ERA while giving up 8.4 hits per nine innings. He has a strikeout to walk ratio of 2.39 and he has faced 896 opposing hitters during his pro baseball career. He has surrendered a total of 90 earned runs while holding a WHIP of 1.344 and being the owner of a FIP of 3.9. So far in his career, Burke has allowed 193 base hits while he has tallied 201 K's in 206 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+120)

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