Minnesota Twins vs Chicago White Sox Prediction, 5/27/2026 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs Chicago White Sox

Date: Wednesday, May 27, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Minnesota (-132) Chicago (+110)

The Minnesota Twins (26-28) are headed to Rate Field on Wednesday where they will take on the Chicago White Sox (27-26). The moneyline on this game has the Twins at -132 and the White Sox are coming in at +110. The over/under has been set at 8. The pitchers who are expected to start are Connor Prielipp and Davis Martin.

As a unit, the Minnesota Twins are recording 4.6 runs per contest, which has them at 10th in MLB. They are sitting with 249 runs while holding a team on-base percentage of .324. The Twins have recorded 83 doubles as a squad and have knocked 58 balls out of the park. They have tallied 235 RBI's as well as 432 base knocks on the campaign, and their batting average is at .239. Minnesota has a slugging rate of .388 and have struck out 469 times, while taking a walk on 196 occasions.

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Their strikeout to walk ratio sits at 2.17 and their pitching staff has earned a collective WHIP of 1.31. Twins pitchers have surrendered 48 long balls in addition to 247 runs in total (21st in the league). Minnesota has conceded 433 hits (8.2 per 9 innings) and also 221 earned runs. The Twins have a team ERA of 4.18 this year (19th in the league), and their staff has rung up 414 batters. Their pitching staff has walked 191 opposing hitters and their FIP is 4.05 as a squad this year.

The Twins bullpen have recorded a save percentage of 70.0% and have come into the game in 62 save situations. They have recorded 14 saves for the season and have missed out on 6 out of their 20 chances to get a save. The bullpen pitchers have inherited 89 base runners over the course of the season and 30.3% of them crossing the plate. Twins pitchers have stepped onto the hill with runners on 59 times in addition to having 55 appearances in high leverage situations. The Twins have dispatched 178 relief pitchers to the hill over the course of the season. The relief pitchers have a total of 41 holds for the season (3rd in MLB).

The Minnesota Twins have earned a total of 1,428 putouts for the season, as well as 405 assists and 28 errors. Their fielding percentage is currently at .985 which has them ranked 23rd in the majors, and have accumulated 41 double plays. The Twins have turned 70.3% of balls in play into outs out of their 4,284 innings, which has them sitting at 17th in professional baseball.

Prielipp (1-2 mark in his career) sits with a FIP of 3.97 and he has faced 123 hitters in the majors. He has surrendered 22 base hits (6.8 hits per 9 innings) and has had 12 walks. His earned run average is 4.03 (13 ER's allowed) and he has a WHIP of 1.172. Prielipp has thrown 29 frames and has earned 30 strikeouts during his MLB career.

The Chicago White Sox have a team OBP of .322 as well as a batting average of .232 on the campaign. They have been called out on strikes on 492 instances (5th in MLB) and have earned a total of 403 base hits. Chicago has hit 72 home runs over the course of the season and 226 RBIs. The White Sox have a team slugging percentage of .399 and they average 4.49 runs per outing (12th in the league). They have put up 63 two-baggers, while getting a free base 202 times and racking up 238 runs.

The White Sox have a WHIP of 1.361 and have a FIP of 4.45 as a team so far this season. Their K/BB ratio is 8.20 (427 strikeouts against 210 walks). They come in at 15th in baseball as a pitching staff in total hits relinquished with 427. They have surrendered 59 dingers and they relinquish 4.86 runs per 9 innings (24th in baseball). The Chicago pitching staff have yielded 253 runs on the campaign while having an ERA of 4.48 (233 earned runs allowed).

Sitting with 46 save situations, the White Sox have accumulated 18 holds and also 11 blown saves. Chicago has had relief pitchers enter the game in 28 save opportunities and they have walked away with 17 saves. Chicago relief pitchers hold an inherited score percentage of 34.8% of 92 inherited runners. Their relief pitchers have stepped onto the mound 51 times in high leverage situations and on 60 occasions with base runners. They are ranked 18th in MLB with a save percentage of 60.7%, and they have sent 184 bullpen pitchers onto the field so far this season.

Out of their 4,218 innings on the field, the White Sox are sitting with a efficiency on defense of 70.5% (13th in the majors). The Chicago White Sox have gotten 36 double plays and hold a fielding percentage of .985 (19th in pro baseball). The White Sox have 469 assists, 28 errors and have a total of 1,406 putouts on the campaign.

Martin (17-22 record in his career) holds a 3.89 earned run average while conceding 8.5 hits per 9 innings. His K/BB ratio is 2.60 and he has gone up against 1,331 batters thus far in his career. He has given up a total of 137 earned runs while earning a WHIP of 1.267 and being the owner of a FIP of 3.8. During his pro baseball career, Martin has surrendered 300 base knocks while totaling 265 strikeouts in 317 frames.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (+110)

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