Minnesota Twins vs New York Mets Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs New York Mets

Date: Wednesday, April 22, 2026

Location: Citi Field in Queens, NY

TV: Sportsnet New York

Odds/Point Spread: Minnesota (-130) New York (+110)

Citi Field is where the New York Mets (7-15) will play the Minnesota Twins (11-11) on Wednesday. The moneyline on this game has Minnesota at -130 and New York is opening at +110. The total is 8.5. The starting pitchers will be Joe Ryan and Clay Holmes.

The Twins have tallied 27 doubles as a squad and have hit 26 balls out of the stadium. Minnesota has a slugging % of .381 and have struck out 193 times, while being walked on 98 occasions. As a squad, the Minnesota Twins are notching 5.1 runs per outing, which is 7th in the league. They have recorded 107 runs batted in as well as 166 hits on the season, and their team batting average is sitting at .230. They have tallied 112 runs while holding a team OBP of .332.

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They have accumulated a K/BB ratio of 2.35 and their pitching staff has recorded a WHIP of 1.37. Twins pitchers have allowed 13 home runs in addition to 100 total runs (14th in the league). Minnesota has given up 189 base hits (8.7 per 9 innings) and 88 earned runs. The Twins have compiled a team earned run average of 4.06 for the season (16th in baseball), and the staff has rung up 183 hitters. Their pitching staff has walked 78 opposing batters and their FIP is 3.58 as a unit this year.

The Twins bullpen have compiled a save rate of 62.5% and have come into the game in 25 save situations. They have tallied 5 saves for the year and have blown 3 out of their 8 save opportunities. The bullpen pitchers have inherited 30 base runners for the season with 23.3% of those runners crossing home plate. Twins relief pitchers have come into the game with players on base 21 times in addition to having 18 appearances in high leverage situations. The Twins have sent 73 relief pitchers to the mound this year. The relief pitchers have racked up 17 holds for the season (8th in MLB).

The Milwaukee Brewers have amassed 585 putouts on the year, as well as 161 assists and 14 errors. Their fielding percentage is holding steady at .982 which has them sitting 25th in professional baseball, and they have turned 18 double plays. The Twins have converted 67.1% of balls in play into outs out of their 1,755 innings, which has them sitting 27th in baseball.

Ryan (48-38 mark in his career) holds a FIP of 3.71 and he has gone up against 2,710 opposing hitters in the major leagues. He has allowed 552 hits (7.4 hits per nine innings) and has had 154 free passes. His earned run average is 3.77 (280 ER's allowed) and his WHIP is 1.057. Ryan has taken the hill for 668 innings and is sitting with 747 K's in his MLB career.

New York has compiled 16 long balls so far this season and 68 runs batted in. They have recorded 29 two-baggers, while getting a free base 64 times and scoring 72 runs. The New York Mets have compiled a team OBP of .288 as well as a team batting average of .226 this season. The Mets hold a slugging percentage of .336 and they average 3.27 runs per game (30th in the league). They have struck out on 178 occasions (24th in baseball) and have totaled 169 hits.

The Mets have a team WHIP of 1.284 and have a FIP of 3.82 as a team on the campaign. They rank 18th in baseball as a pitching staff in total hits relinquished with 178. The New York pitching staff have relinquished 97 runs on the campaign while holding an ERA of 4.06 (89 earned runs surrendered). They have earned a strikeout to walk ratio of 8.70 (190 strikeouts vs 75 walks). They have surrendered 21 homers and they allow 4.43 runs per 9 innings (12th in MLB).

New York relievers hold an inherited score percentage of 52.4% out of 21 inherited runners. Their relievers have stepped onto the hill 27 times in high leverage situations in addition to 20 occasions with runners on. Sitting with 12 save situations, the Mets have compiled 7 holds in addition to 3 blown saves. They sit at 28th in MLB holding a save rate of 40.0%, and they have sent 64 bullpen pitchers to the mound this season.

The New York Mets have turned 14 double plays and own a fielding percentage of .986 (13th in pro baseball). The Mets have 202 assists, 11 errors and have amassed 592 putouts during this campaign. In 1,776 innings played, the Mets have earned a efficiency on defense of 70.0% (18th in professional baseball).

Holmes (38-32 career record) has a 3.58 earned run average and has allowed 7.7 hits per 9 innings. His strikeout to walk ratio is 2.21 and he has gone up against 2,261 hitters during his MLB career. He has conceded 209 ER's while earning a WHIP of 1.293 and having a FIP of 3.5. During his pro baseball career, Holmes has allowed 452 hits while accumulating 505 punch outs in 526 frames.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take New York (+110)

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