Minnesota Twins vs San Diego Padres Prediction, 8/22/2026 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs San Diego Padres

Date: Saturday, August 22, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Minnesota (+120) San Diego (-144)

The Minnesota Twins (63-65) are en route to Petco Park on Saturday where they will take on the San Diego Padres (68-60). The moneyline on this contest has the Twins at +120 while the Padres are sitting at -144. The betting total comes in at 9. The starting pitchers will be Dean Kremer and Casey Mize.

Minnesota has a slugging percentage of .406 and have been called out on strikes 1,035 times, while being walked on 420 occasions. They have accrued 564 runs batted in in addition to 1,062 hits on the year, while their average at the plate sits at .246. The Twins have accounted for 210 doubles as a unit and have knocked 147 baseballs out of the park. They have a total of 592 runs scored while holding a team OBP of .321. As a unit, the Minnesota Twins are scoring 4.6 runs per outing, which is 9th in the league.

Get all of our MLB Betting Picks

The Twins hold a team earned run average of 4.62 on the year (25th in baseball), and the staff has struck out 1,058 batters. Twins pitchers have yielded 147 long balls and also 633 runs in total (26th in MLB). Their pitching staff has walked 466 opposing batters and their FIP is 4.29 as a unit on the year. Minnesota has conceded 1,091 base hits (8.7 per 9 innings) as well as 580 earned runs. Their K/BB ratio is 2.27 and the pitching staff has a collective WHIP of 1.38.

The Twins bullpen have accumulated a save percentage of 72.5% and stepped onto the hill in 141 save situations. They have compiled 37 saves so far this year and have not converted 14 of their 51 save chances. The relievers have inherited 177 base runners on the year and 36.2% of those players crossing home plate. Twins pitchers have stepped onto the hill with runners on 122 times and also have had 140 appearances in high leverage situations. The Twins have sent 427 relief pitchers to the hill this season. The bullpen have earned 86 holds for the season (4th in MLB).

The Twins have converted 69.3% of balls in play into outs out of their 10,176 innings on the field, which ranks them 24th in the majors. The Minnesota Twins have accounted for 3,392 putouts for the season, as well as 974 assists and 59 errors. Their fielding percentage is at .987 which is 12th in MLB, and have 86 double plays.

Kremer has pitched in 707 frames and has earned 616 strikeouts so far in his pro baseball career. Kremer (42-44 win-loss record in his career) sits with a FIP of 4.31 and he has faced 2,989 batters in the major leagues. His earned run average is 4.38 (344 ER's allowed) and he has a career WHIP of 1.295. He has surrendered 683 hits (8.7 hits per 9 innings) and has had 233 walks.

San Diego has 143 home runs for the season to go along with 524 runs batted in. They have tallied 186 two-baggers, while getting a free base 439 times and racking up 543 runs. The San Diego Padres have tallied a team on-base percentage of .315 in addition to a team batting average of .238 for the year. The Padres hold a team slugging % of .389 and they earn 4.24 runs per outing (21st in baseball). They have been called out on strikes on 1,038 occasions (21st in MLB) and have recorded 1,001 base hits.

The Padres have a team WHIP of 1.307 and are the owners of a FIP of 4.17 as a squad for the season. Their K/BB ratio sits at 8.30 (1,036 strikeouts vs 442 free passes). They have a ranking of 15th in the league as a pitching staff in total hits conceded with 1,035. They have given up 140 homers and they relinquish 4.30 runs per 9 innings (9th in MLB). The San Diego pitching staff have conceded 540 runs so far this season while holding a team ERA of 4.05 (508 earned runs yielded).

San Diego bullpen pitchers have an inherited score percentage of 31.7% out of their 205 inherited base runners. Their relief pitchers have stepped onto the hill 140 times in high leverage situations and on 121 occasions with base runners. Sitting with 135 save situations, the Padres have accrued 79 holds in addition to 15 blown saves. They are currently ranked 7th in baseball with a save percentage of 71.7%, and they have sent 428 bullpen pitchers to the hill for the season.

The San Diego Padres have turned 103 double plays and have a fielding percentage of .988 (5th in baseball). The Padres have accrued 1,124 assists, 55 errors and have 3,390 putouts this season. In 10,170 innings on the field, the Padres hold a defensive efficiency of 70.3% (12th in professional baseball).

Mize (24-26 career record) has a 4.25 earned run average and has conceded 9.2 hits per nine innings. He has a strikeout to walk ratio of 2.95 and he has faced 1,936 opposing hitters during his pro baseball career. He has allowed 215 earned runs while earning a WHIP of 1.296 and having a FIP of 4.2. In his pro baseball career, Mize has allowed 463 hits while he has earned 375 strikeouts in 455 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Minnesota (+120)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.