Minnesota Twins vs San Francisco Giants Prediction, 9/22/2026 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs San Francisco Giants

Date: Tuesday, September 22, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Minnesota (+162) San Francisco (-196)

The Minnesota Twins (73-83) are en route to Oracle Park on Tuesday where they will take on the San Francisco Giants (64-92). The moneyline on this contest has the Twins at +162 and the Giants are opening at -196. The over/under is set at 8.5. The pitchers taking the mound are Taj Bradley and Anthony Molina.

As a squad, the Minnesota Twins are putting up 4.6 runs per game, which puts them at 10th in baseball. They have earned 712 runs while holding a team OBP of .317. The Twins have tallied 250 doubles as a unit and have hit 180 balls out of the stadium. They have recorded 681 RBI's and 1,289 base knocks over the course of the season, and their average at the plate is sitting at .244. Minnesota has a slugging percentage of .403 and have struck out 1,254 times, while being walked on 492 occasions.

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They have accumulated a K/BB ratio of 2.33 and the pitching staff holds a WHIP of 1.37. Twins pitchers have yielded 180 home runs and also 776 total runs (26th in baseball). Minnesota has surrendered 1,322 base hits (8.6 per 9 innings) as well as 706 earned runs. The Twins have an ERA of 4.60 this year (25th in the league), and their staff has struck out 1,325 hitters. They have walked 568 players from the other team and their FIP is 4.25 as a unit so far this year.

The Twins relievers have a save rate of 67.2% and have stepped onto the mound in 172 save situations. They have compiled 43 saves over the course of the season and have not converted 21 of their 64 save opportunities. The relievers have inherited 222 base runners this season with 36.9% of those runners earned a run for their team. Twins pitchers have stepped onto the hill with runners on 156 times and also have had 171 appearances in high leverage situations. The Twins have dispatched 520 relief pitchers to the hill over the course of the season. The relief pitchers have 104 holds over the course of the season (4th in MLB).

The Twins have converted 69.3% of balls hit into play into outs out of their 12,444 innings on the diamond, which has them ranked 22nd in baseball. The Minnesota Twins have earned 4,148 putouts this season, in addition to 1,184 assists and 71 errors. Their fielding percentage is at .987 which has them ranked 11th in the majors, and have a total of 106 double plays.

Bradley has pitched in 557 innings and has accumulated 609 K's in his career. Bradley (30-33 career mark) holds a FIP of 4.47 while he has gone up against 2,367 opposing batters during his time in the majors. His ERA is 4.54 (281 earned runs allowed) and he has a WHIP of 1.280. He has conceded 498 hits (8.0 hits per nine innings) and has 215 free passes.

The Giants have a slugging percentage of .405 and they have an average of 4.21 runs per contest (24th in MLB). They have tallied 255 doubles, while getting a free base 437 times and putting up 656 runs. San Francisco has accounted for 177 home runs on the year as well as 633 RBIs. They have struck out on 1,272 instances (19th in baseball) and have totaled 1,303 hits. The San Francisco Giants are sitting with an on-base percentage of .308 and a team batting average of .247 this season.

The Giants hold a team WHIP of 1.369 and have a FIP of 4.25 as a staff on the campaign. Their strikeout to walk ratio comes in at 7.60 (1,159 strikeouts vs 581 walks). They sit at 18th in MLB as a pitching staff in total hits surrendered with 1,302. They have surrendered 151 HR's and they concede 4.84 runs per 9 innings (23rd in MLB). The San Francisco pitching staff have relinquished 740 runs on the season while having an ERA of 4.39 (670 earned runs relinquished).

San Francisco relievers have an inherited score percentage of 34.6% out of their 280 inherited runners. Their relief pitchers have stepped onto the mound 137 times in high leverage situations and on 179 occasions with runners on base. With 138 save situations, the Giants have accrued 83 holds and 26 blown saves. They rank 27th in MLB with a save rate of 52.7%, and they have sent 498 bullpen pitchers onto the diamond for the season.

The San Francisco Giants have turned 140 double plays and have accounted for a fielding rate of .982 (30th in pro baseball). The Giants have recorded 1,460 assists, 104 errors and are sitting with 4,125 putouts over the course of the season. Out of their 12,375 innings on the diamond, the Giants have earned a defensive efficiency of 69.5% (17th in the majors).

Molina (2-2 career win-loss record) is the owner of a 6.90 ERA and has given up 11.8 hits per nine innings. He has a strikeout to walk ratio of 2.31 and he has gone up against 445 hitters during his pro baseball career. He has surrendered 76 earned runs while holding a WHIP of 1.604 and a FIP of 6.8. During his pro baseball career, Molina has surrendered 130 hits while he has tallied 67 strikeouts in 99 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take San Francisco (-196)

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