Minnesota Twins vs San Francisco Giants Prediction, 9/23/2026 MLB Picks, Best Bets & Odds

Game: Minnesota Twins vs San Francisco Giants

Date: Wednesday, September 23, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Minnesota (+120) San Francisco (-144)

The San Francisco Giants (65-92) will take on the Minnesota Twins (73-84) at Oracle Park on Wednesday. The line on this matchup has Minnesota at +120 while San Francisco opens at -144. The over/under is set at 9. The pitchers taking the mound are Connor Prielipp and Cesar Perdomo.

Minnesota has a slugging % of .402 and have been rung up 1,262 times, while taking a walk on 493 occasions. They have accounted for 683 RBI's and 1,293 base knocks on the year, while their team batting average is .244. The Twins have tallied 250 doubles as a unit and have hit 182 baseballs out of the park. They have accumulated 714 runs scored while holding a team OBP of .316. As a unit, the Minnesota Twins are putting up 4.6 runs per game, which has them at 11th in MLB.

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The Twins have compiled a team earned run average of 4.60 for the season (25th in MLB), and the staff has struck out 1,338 hitters. Twins pitchers have conceded 181 home runs and also 781 runs (26th in baseball). They have walked 568 players from the other team and their FIP sits at 4.24 as a unit for the season. Minnesota has given up 1,332 hits (8.6 per 9 innings) in addition to 711 earned runs. They have a K/BB ratio of 2.36 and the pitching staff holds a collective WHIP of 1.37.

Twins bullpen pitchers have gone to the mound with opponents on base 156 times and also have had 171 appearances in high leverage situations. The relievers have earned 104 holds this year (4th in the league). The Twins relievers have a save rate of 67.2% and stepped onto the hill in 172 save situations. They have accumulated 43 saves on the campaign and have blown 21 out of their 64 chances to get a save. The bullpen pitchers have inherited 222 base runners for the season with 36.9% of those players crossing home plate. The Twins have sent 522 relief pitchers to the hill so far this season.

The Minnesota Twins have accounted for 4,172 putouts at this point in the season, in addition to 1,191 assists and 71 errors. Their fielding percentage is at .987 which is 11th in professional baseball, and have a total of 107 double plays. The Twins have turned 69.2% of balls hit into play into outs out of their 12,516 innings, ranking them 23rd in professional baseball.

Prielipp has thrown 120 innings and has totaled 125 strikeouts thus far in his career. His earned run average is 4.95 (66 earned runs allowed) and his career WHIP is 1.299. He has surrendered 114 hits (8.5 hits per 9 innings) and has 42 walks. Prielipp (6-7 record in his career) holds a FIP of 4.87 while going up against 513 opposing batters in the major leagues.

San Francisco has a total of 178 long balls this season as well as 638 RBIs. They have put up 257 doubles, while getting a free base 437 times as well as putting up 661 runs. The San Francisco Giants have recorded a team OBP of .308 as well as a team batting average of .247 on the year. The Giants have a team SLG% of .405 and they score 4.21 runs per contest (24th in the league). They have struck out on 1,285 occasions (17th in the league) and have recorded 1,313 base hits.

The San Francisco pitching staff have surrendered 742 runs so far this season while having a team ERA of 4.37 (672 earned runs yielded). They have surrendered 153 long balls and they surrender 4.83 runs per 9 innings (23rd in MLB). The Giants hold a team WHIP of 1.364 and are the owners of a FIP of 4.25 as a squad this season. Their strikeout to walk ratio sits at 7.60 (1,167 strikeouts vs 582 free passes). They rank 19th in MLB as a staff in total hits allowed with 1,306.

Sitting with 139 save situations, the Giants have 83 holds in addition to 26 blown saves. San Francisco has had relievers enter the game in 56 save opportunities and they have recorded 30 saves. San Francisco relief pitchers hold an inherited score rate of 34.6% out of their 280 inherited base runners. Their relief pitchers have stepped onto the mound 137 times in high leverage situations and on 179 occasions with runners on. They are currently ranked 27th in the league with a save rate of 53.6%, and they have dispatched 502 bullpen pitchers onto the field this season.

Out of their 12,456 innings played, the Giants have accumulated a efficiency on defense of 69.6% (15th in pro baseball). The San Francisco Giants have turned 141 double plays and have earned a fielding percentage of .982 (29th in pro baseball). The Giants have recorded 1,470 assists, 104 errors and have 4,152 putouts this season.

Perdomo (0-1 record in his career) holds a 3.77 earned run average while allowing 10.4 hits per 9 innings. His strikeout to walk ratio is 1.71 and he has faced 83 hitters during his MLB career. He has allowed 8 earned runs while earning a WHIP of 1.518 and a FIP of 3.7. During his MLB career, Perdomo has conceded 22 base hits while he has accumulated 12 punch outs in 19 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take San Francisco (-144)

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