New York Yankees vs Boston Red Sox Prediction, 4/21/2026 MLB Picks, Best Bets & Odds

Game: New York Yankees vs Boston Red Sox

Date: Tuesday, April 21, 2026

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: New York (-144) Boston (+120)

The Boston Red Sox (8-13) will play the New York Yankees (13-9) at Fenway Park on Tuesday. The odds on this game have the Yankees at -144 while the Red Sox are priced at +120. The betting total is set at 9. The men taking the mound are Luis Gil and Connelly Early.

As a squad, the New York Yankees are putting up 5.0 runs per contest, which has them sitting at 10th in baseball. They are sitting with 110 runs scored while having a team OBP of .323. The Yankees have tallied 32 two-baggers as a team and have smacked 32 baseballs out of the stadium. They have tallied 103 RBI's and 155 base knocks over the course of the season, and their batting average is sitting at .218. New York is slugging .410 and have been rung up 203 times, while drawing a walk on 109 occasions.

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They have earned a strikeout to walk ratio of 3.35 and their pitching staff has recorded a WHIP of 1.17. Yankees pitchers have conceded 18 long balls in addition to 82 runs (6th in the league). New York has allowed 168 base hits (7.7 per 9 innings) in addition to 74 earned runs. The Yankees have a team earned run average of 3.40 for the year (6th in MLB), and they have struck out 201 batters. They have walked 60 players from the other team and their FIP comes in at 3.33 as a team on the season.

The Yankees have dispatched 73 relievers to the hill so far this season. The relief pitchers have inherited 36 base runners this year and 33.3% of those runners ended up scoring. The relievers have earned 9 holds this year (26th in baseball). Yankees relief pitchers have stepped onto the hill with runners on 25 times and also have had 26 appearances in high leverage situations. They have tallied 6 saves so far this season and have not converted 5 out of their 11 chances to get a save. The Yankees relief pitchers have recorded a save percentage of 54.5% and have entered the game in 21 save situations.

The Yankees have converted 69.9% of balls hit into play into outs out of their 1,761 innings on the diamond, which has them sitting 19th in MLB. The New York Mets have 587 putouts on the campaign, in addition to 194 assists and 12 errors. Their fielding percentage sits at .985 which is 18th in the majors, and they have turned 13 double plays.

Gil (20-10 career win-loss mark) has earned a FIP of 3.57 while he has faced 1,070 opposing hitters in the major leagues. He has surrendered 184 hits (6.6 hits per 9 innings) and has 136 free passes. His ERA is 3.62 (101 ER's allowed) and he has a WHIP of 1.275. Gil has taken the ball for 251 innings and has earned 262 K's during his career.

The Red Sox have a SLG% of .341 and they score 3.86 runs per contest (24th in the league). They have tallied 36 two-baggers, while walking 69 times and scoring 81 runs. Boston has accumulated 13 long balls this season and 77 RBIs. They have been called out on strikes on 191 occasions (12th in baseball) and have totaled 159 hits. The Boston Red Sox hold an OBP of .310 in addition to a batting average of .228 so far this year.

The Red Sox are sitting with a team WHIP of 1.325 and have a FIP of 4.75 as a unit this year. They are currently ranked 8th in baseball as a pitching staff in total hits given up with 167. The Boston pitching staff have conceded 96 runs for the season and come in with a team ERA of 4.35 (89 earned runs allowed). Their K/BB ratio comes in at 8.00 (163 strikeouts against 77 bases on balls). They have surrendered 28 long balls and they surrender 4.69 runs per 9 innings (19th in the league).

Boston relievers have an inherited score rate of 28.6% of 21 inherited runners. Their relief pitchers have taken the field 20 times in high leverage situations and also on 15 occasions with base runners. With 15 save situations, the Red Sox have earned 10 holds in addition to 2 blown saves. They are ranked 19th in baseball with a save percentage of 60.0%, and they have sent 64 bullpen pitchers onto the field on the season.

The Boston Red Sox have gotten 12 double plays and have a fielding rate of .982 (24th in professional baseball). The Red Sox have racked up 202 assists, 14 errors and have accounted for 553 putouts this season. Out of their 1,659 innings on the diamond, the Red Sox have a defensive efficiency of 71.4% (6th in MLB).

During his MLB career, Early has conceded 32 hits while tallying 49 strikeouts in 38 innings. He has given up a total of 10 ER's while holding a WHIP of 1.201 and having a FIP of 2.3. He has a K/BB ratio of 3.50 and he has gone up against 163 opposing batters in his MLB career. Early (2-2 career win-loss record) has earned a 2.35 earned run average while giving up 7.5 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Boston (+120)

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