New York Yankees vs Boston Red Sox Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: New York Yankees vs Boston Red Sox

Date: Wednesday, April 22, 2026

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: New York (-152) Boston (+126)

Fenway Park is the location where the Boston Red Sox (9-13) will try to defeat the New York Yankees (13-9) on Wednesday. The odds on this game have New York at -152 while Boston is opening at +126. The betting total is set at 8.5. The starting pitchers will be Max Fried and Ranger Suarez.

The Yankees have accumulated 32 two-baggers as a unit and have hit 32 balls out of the stadium. New York is slugging .410 and have been called out on strikes 203 times, while taking a walk on 109 occasions. As a squad, the New York Yankees are scoring 5.0 runs per game, which puts them at 9th in baseball. They have 103 RBI's as well as 155 base knocks for the season, while their average at the plate comes in at .218. They have earned a total of 110 runs and have an on-base percentage of .323.

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The Yankees have a team earned run average of 3.40 this season (6th in MLB), and the staff has struck out 201 batters. Yankees pitchers have conceded 18 home runs in addition to 82 total runs (4th in MLB). Their pitching staff has walked 60 opposing batters and their FIP sits at 3.33 as a unit for the year. New York has relinquished 168 base hits (7.7 per 9 innings) and also 74 earned runs. They have a strikeout to walk ratio of 3.35 and the pitching staff has earned a collective WHIP of 1.17.

Yankees relief pitchers have come into the game with runners on 25 times in addition to having 26 appearances in high leverage situations. The bullpen have tallied 9 holds so far this season (26th in baseball). The Yankees relievers have a save percentage of 54.5% and have come into the game in 21 save situations. They have earned 6 saves so far this season and have missed out on 5 of their 11 save chances. The relievers have inherited 36 base runners for the season with 33.3% of those players ended up crossing the plate. The Yankees have sent 73 relievers to the hill on the campaign.

The Yankees have converted 69.9% of balls in play into outs out of their 1,761 innings on the field, which has them ranked 19th in professional baseball. The New York Mets have amassed 587 putouts so far this season, as well as 194 assists and 12 errors. Their fielding percentage is holding steady at .985 which is 18th in baseball, and have accumulated 13 double plays.

Fried has thrown 1,112 innings and is sitting with 1,075 punch outs in his career. Fried (94-42 win-loss mark in his career) sits with a FIP of 2.99 while he has faced 4,542 hitters in the majors. His earned run average is 3.03 (375 earned runs allowed) and his WHIP is 1.143. He has given up 966 hits (7.8 hits per nine innings) and has 305 walks.

The Red Sox have a slugging percentage of .345 and they score 4.05 runs per outing (20th in MLB). They have 39 doubles, while getting a free base 77 times as well as earning 89 runs. Boston is sitting with 13 long balls over the course of the season to go along with 84 RBIs. They have been rung up on 198 occasions (12th in baseball) and have tallied 171 hits. The Boston Red Sox have earned a team on-base percentage of .318 as well as a batting average of .233 on the season.

The Boston pitching staff have surrendered 102 runs so far this season while holding a team ERA of 4.43 (95 earned runs relinquished). They have relinquished 28 home runs and they allow 4.75 runs per 9 innings (20th in MLB). The Red Sox hold a team WHIP of 1.336 and have a FIP of 4.68 as a squad this year. Their strikeout to walk ratio sits at 7.90 (170 strikeouts vs 81 walks). They are sitting at 16th in the league as a staff in total hits given up with 177.

They are ranked 20th in baseball holding a save rate of 57.1%, and they have sent 71 relievers to the hill for the year. Their bullpen pitchers have stepped onto the mound 23 times in high leverage situations and on 19 occasions with runners on. Sitting with 18 save situations, the Red Sox have earned 11 holds in addition to 3 blown saves. Boston has had relief pitchers enter the game in 7 save chances and they have tallied 4 saves. Boston bullpen pitchers hold an inherited score rate of 31.0% out of their 29 inherited runners.

In 1,740 innings on the field, the Red Sox have earned a efficiency on defense of 71.0% (11th in baseball). The Boston Red Sox have gotten 13 double plays and own a fielding percentage of .983 (21st in pro baseball). The Red Sox have 216 assists, 14 errors and have a total of 580 putouts so far this season.

During his MLB career, Suarez has surrendered 746 hits while he has tallied 720 strikeouts in 784 innings pitched. He has given up 294 earned runs while earning a WHIP of 1.265 and being the owner of a FIP of 3.3. He has a K/BB ratio of 2.93 and he has faced 3,283 opposing hitters so far in his career. Suarez (54-38 win-loss mark in his career) has earned a 3.37 ERA and has surrendered 8.6 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take New York (-152)

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