New York Yankees vs Houston Astros Prediction, 4/25/2026 MLB Picks, Best Bets & Odds

Game: New York Yankees vs Houston Astros

Date: Saturday, April 25, 2026

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: New York (-122) Houston (+102)

Daikin Park is the location where the Houston Astros (10-16) will compete against the New York Yankees (16-9) on Saturday. The line on this contest has the Yankees at -122 while the Astros are priced at +102. The over/under comes in at 8.5. The expected starting pitchers will be Ryan Weathers and Mike Burrows.

The Yankees have accumulated 37 doubles as a team and have hit 35 baseballs out of the stadium. New York is slugging .408 and have been called out on strikes 238 times, while drawing a walk on 117 occasions. As a team, the New York Yankees are scoring 4.9 runs per game, which is 9th in baseball. They have accumulated 115 runs batted in and 181 base knocks for the year, while their batting average sits at .223. They have racked up 122 runs scored and hold an OBP of .322.

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The Yankees have a team earned run average of 3.07 this year (1st in the league), and they have rung up 219 hitters. Yankees pitchers have relinquished 19 home runs and also 85 total runs (2nd in the league). They have walked 66 players from the other team and their FIP is 3.31 as a unit for the season. New York has given up 181 hits (7.3 per 9 innings) and 76 earned runs. They have accrued a K/BB ratio of 3.32 and the pitching staff holds a collective WHIP of 1.11.

The Yankees have sent 78 relievers to the mound so far this year. The relief pitchers have inherited 39 base runners on the season and 30.8% of those runners ended up crossing the plate. The relief pitchers have a total of 10 holds on the year (27th in MLB). Yankees bullpen pitchers have stepped onto the hill with runners on 27 times in addition to having 28 appearances in high leverage situations. They have accumulated 7 saves for the season and have not converted 5 out of their 12 save opportunities. The Yankees relievers have a save percentage of 58.3% and have entered the game in 23 save situations.

The New York Yankees have a total of 668 putouts at this point in the season, as well as 225 assists and 13 errors. Their fielding percentage is holding steady at .986 which has them sitting 14th in pro baseball, and they have turned 15 double plays. The Yankees have turned 71.5% of baseballs in play into outs out of 2,004 innings on the field, which has them sitting 6th in baseball.

Weathers (13-25 mark in his career) sits with a FIP of 4.70 while he has gone up against 1,328 opposing hitters in the majors. He has conceded 317 base hits (9.2 hits per nine innings) and has 107 free passes. His earned run average is 4.78 (164 ER's allowed) and his WHIP is 1.372. Weathers has thrown 309 innings and has accumulated 271 strikeouts in his career.

Houston has knocked in 31 home runs this year to go along with 129 RBIs. They have hit 59 two-baggers, while taking a walk 113 times as well as racking up 137 runs. The Houston Astros have tallied an on-base percentage of .349 and a batting average of .259 so far this year. The Astros have a SLG% of .434 and they score 5.27 runs per contest (5th in MLB). They have struck out on 197 occasions (25th in baseball) and have recorded 229 base hits.

The Houston pitching staff have conceded 150 runs on the campaign while having an ERA of 5.81 (146 earned runs yielded). They have yielded 35 homers and they concede 5.97 runs per 9 innings (29th in baseball). The Astros have a team WHIP of 1.632 in addition to having a FIP of 5.13 as a team on the year. They currently have a strikeout to walk ratio of 9.70 (245 strikeouts against 141 walks). They come in at 27th in the league as a staff in total hits surrendered with 228.

Sitting with 19 save situations, the Astros have amassed 12 holds in addition to 1 blown save. Houston has had bullpen pitchers step onto the mound in 7 save chances and they have walked away with 6 saves. Houston bullpen pitchers have an inherited score rate of 31.0% of 58 inherited base runners. Their relief pitchers have stepped onto the mound 22 times in high leverage situations in addition to 34 occasions with base runners. They are currently ranked 2nd in the league with a save percentage of 85.7%, and they have sent 84 bullpen pitchers onto the field this year.

The Houston Astros have gotten 25 double plays and have a fielding percentage of .990 (5th in pro baseball). The Astros have accrued 187 assists, 9 errors and have accumulated 679 putouts on the season. In their 2,037 innings played, the Astros hold a efficiency on defense of 66.8% (29th in pro baseball).

So far in his MLB career, Burrows has given up 126 base knocks and he has 124 punch outs in 125 frames. Burrows (4-7 career win-loss mark) holds a 4.53 earned run average while surrendering 9.1 hits per 9 innings. He has allowed a total of 63 earned runs while holding a WHIP of 1.349 and having a FIP of 4.5. He has a strikeout to walk ratio of 2.88 and he has faced 538 hitters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take New York (-122)

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