New York Yankees vs Minnesota Twins Prediction, 9/16/2026 MLB Picks, Best Bets & Odds

Game: New York Yankees vs Minnesota Twins

Date: Wednesday, September 16, 2026

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: New York (-130) Minnesota (+110)

Target Field is the location where the Minnesota Twins (70-80) will attempt to beat the New York Yankees (87-63) on Wednesday. The odds on this game have the Yankees at -130 and the Twins are opening at +110. The total comes in at 8.5. The men taking the mound are Carlos Rodon and Zebby Matthews.

As a unit, the New York Yankees are earning 4.6 runs per game, which is 11th in MLB. They have 685 runs while holding a team on-base percentage of .312. The Yankees have tallied 213 doubles as a unit and have knocked 207 balls out of the stadium. They have amassed 654 RBI's and 1,162 base knocks on the season, while their team batting average sits at .235. New York has a slugging % of .410 and have struck out 1,371 times, while taking a walk on 534 occasions.

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Their strikeout to walk ratio is 2.98 and the pitching staff has a collective WHIP of 1.16. Yankees pitchers have given up 155 home runs in addition to 555 runs in total (1st in MLB). New York has given up 1,109 hits (7.4 per 9 innings) and also 480 earned runs. The Yankees hold a team earned run average of 3.22 on the campaign (1st in MLB), and the staff has rung up 1,346 batters. They have walked 452 opposing batters and their FIP is 3.73 as a squad on the campaign.

Yankees bullpen pitchers have come into the game with runners on base 178 times in addition to having 167 appearances in high leverage situations. The relief pitchers have a total of 86 holds so far this year (11th in baseball). The Yankees relievers have recorded a save rate of 62.0% and stepped onto the hill in 160 save situations. They have 44 saves on the season and have blown 27 out of their 71 save opportunities. The relief pitchers have inherited 255 base runners so far this season and 20.8% of those runners crossing home plate. The Yankees have sent 496 relievers to the mound so far this year.

The New York Yankees have earned 4,023 putouts thus far, as well as 1,298 assists and 89 errors. Their fielding percentage is holding steady at .984 which is 20th in professional baseball, and have 112 double plays. The Yankees have transformed 71.4% of balls hit into play into outs out of 12,069 innings, which ranks them 5th in the majors.

Rodon (99-75 win-loss mark in his career) has a FIP of 3.64 and he has faced 5,668 opposing batters during his time in the major leagues. He has conceded 1,129 base knocks (7.5 hits per nine innings) with 512 walks. His ERA is 3.69 (555 earned runs allowed) and he has a WHIP of 1.214. Rodon has taken the ball for 1,352 frames and has tallied 1,487 strikeouts thus far in his career.

The Twins have a SLG% of .404 and they average 4.57 runs per game (10th in the league). They have notched 243 doubles, while taking a walk 481 times and scoring 686 runs. Minnesota has tallied 175 HRs over the course of the season as well as 656 RBIs. They have struck out on 1,195 occasions (24th in MLB) and have totaled 1,229 hits. The Minnesota Twins have earned a team on-base percentage of .318 in addition to a batting average of .244 for the year.

The Twins have a team WHIP of 1.376 with a FIP of 4.32 as a pitching staff on the season. They have earned a K/BB ratio of 8.50 (1,255 strikeouts against 544 free passes). They rank 23rd in baseball as a pitching staff in total hits given up with 1,275. They have allowed 176 long balls and they surrender 5.13 runs per 9 innings (26th in baseball). The Minnesota pitching staff have relinquished 753 runs so far this season while holding an ERA of 4.71 (692 earned runs surrendered).

Minnesota relievers hold an inherited score rate of 37.7% out of their 215 inherited base runners. Their relievers have taken the field 159 times in high leverage situations and also on 148 occasions with base runners. With 160 save situations, the Twins have compiled 97 holds and also 18 blown saves. They are currently ranked 9th in the league with a save rate of 69.5%, and they have sent 497 relief pitchers onto the field so far this season.

The Minnesota Twins have turned 102 double plays and own a fielding percentage of .987 (12th in baseball). The Twins have racked up 1,140 assists, 68 errors and have a total of 3,968 putouts on the campaign. In 11,904 innings on the field, the Twins are sitting with a defensive efficiency of 69.3% (21st in pro baseball).

In his pro baseball career, Matthews has surrendered 260 base knocks while accumulating 230 K's in 236 frames. Matthews (15-20 mark in his career) has a 5.45 ERA and has given up 9.9 hits per nine innings. He has allowed a total of 143 ER's while holding a WHIP of 1.406 and being the owner of a FIP of 5.4. He has a strikeout to walk ratio of 3.19 and he has gone up against 1,031 hitters during his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take New York (-130)

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