New York Yankees vs San Diego Padres Prediction, 9/4/2026 MLB Picks, Best Bets & Odds

Game: New York Yankees vs San Diego Padres

Date: Friday, September 4, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: New York (-132) San Diego (+110)

The New York Yankees (80-60) are traveling to Petco Park on Friday where they will compete against the San Diego Padres (73-67). The moneyline on this matchup has New York at -132 while San Diego is at +110. The over/under comes in at 8. The pitchers taking the mound will be Carlos Rodon and Walker Buehler.

As a squad, the New York Yankees are compiling 4.5 runs per game, which is 11th in MLB. They have racked up 636 runs while holding a team on-base percentage of .311. The Yankees have accounted for 201 two-baggers as a squad and have smacked 192 balls out of the park. They have accrued 607 runs batted in and 1,083 hits so far this season, and their average at the plate is sitting at .234. New York has a slugging rate of .409 and have struck out 1,288 times, while taking a walk on 502 occasions.

Get all of our MLB Betting Picks

They have accrued a K/BB ratio of 2.98 and their pitching staff holds a collective WHIP of 1.17. Yankees pitchers have given up 137 home runs and 521 runs in total (1st in MLB). New York has allowed 1,047 base hits (7.5 per 9 innings) and 451 earned runs. The Yankees are sitting with a team earned run average of 3.24 over the course of the season (1st in baseball), and their staff has struck out 1,256 batters. They have walked 421 opposing players and their FIP is 3.65 as a unit on the season.

The Yankees bullpen have a save percentage of 60.6% and have entered the game in 147 save situations. They have compiled 40 saves so far this season and have missed out on 26 of their 66 save opportunities. The relievers have inherited 237 base runners for the year with 20.3% of those players earned a run for their team. Yankees pitchers have entered the game with opponents on base 166 times and also have had 161 appearances in high leverage situations. The Yankees have dispatched 465 relievers to the mound over the course of the season. The relief pitchers are sitting with 79 holds for the year (11th in baseball).

The New York Yankees have accounted for 3,755 putouts on the year, in addition to 1,220 assists and 81 errors. Their fielding percentage is currently at .984 which is 21st in baseball, and they have turned 108 double plays. The Yankees have turned 71.0% of balls in play into outs in their 11,265 innings, ranking them 8th in the majors.

Rodon has thrown 1,341 innings and has totaled 1,472 strikeouts so far in his MLB career. Rodon (97-75 career mark) is the owner of a FIP of 3.66 while he has gone up against 5,625 batters in the majors. His earned run average is 3.71 (553 ER's allowed) and he has a WHIP of 1.217. He has surrendered 1,124 base hits (7.5 hits per nine innings) and has 508 free passes.

The Padres hold a team slugging percentage of .387 and they have an average of 4.24 runs per contest (22nd in MLB). They have recorded 202 doubles, while walking 485 times and racking up 594 runs. San Diego has compiled 153 HRs on the year to go along with 572 runs batted in. They have been called out on strikes on 1,139 occasions (20th in baseball) and have totaled 1,096 base hits. The San Diego Padres are sitting with a team on-base percentage of .315 and a batting average of .237 for the season.

The Padres have a WHIP of 1.292 with a FIP of 4.19 as a staff so far this year. Their K/BB ratio comes in at 8.20 (1,131 strikeouts against 475 walks). They are sitting at 13th in the league as a pitching staff in total hits given up with 1,125. They have allowed 155 dingers and they allow 4.25 runs per 9 innings (9th in baseball). The San Diego pitching staff have given up 584 runs so far this year while holding a team ERA of 3.94 (542 earned runs surrendered).

San Diego bullpen pitchers hold an inherited score rate of 31.8% out of their 220 inherited base runners. Their relievers have come in 156 times in high leverage situations in addition to 136 occasions with runners on. Sitting with 146 save situations, the Padres have amassed 85 holds in addition to 18 blown saves. They are ranked 11th in MLB holding a save rate of 69.0%, and they have dispatched 470 relief pitchers to the mound for the year.

The San Diego Padres have gotten 112 double plays and have notched a fielding percentage of .988 (5th in professional baseball). The Padres have 1,236 assists, 59 errors and have notched a total of 3,715 putouts this year. In 11,145 innings on the field, the Padres hold a efficiency on defense of 70.6% (10th in the majors).

Buehler (65-35 career mark) has earned a 3.67 ERA and has given up 7.9 hits per nine innings. He has a K/BB ratio of 3.19 and he has faced 4,026 batters so far in his career. He has surrendered a total of 396 ER's while holding a WHIP of 1.182 and being the owner of a FIP of 3.6. So far in his career, Buehler has allowed 847 base knocks while accumulating 957 punch outs in 970 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take New York (-132)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.