Philadelphia Phillies vs Chicago Cubs Prediction, 4/21/2026 MLB Picks, Best Bets & Odds

Game: Philadelphia Phillies vs Chicago Cubs

Date: Tuesday, April 21, 2026

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Philadelphia (+126) Chicago (-152)

The Philadelphia Phillies (8-13) are en route to Wrigley Field on Tuesday where they will try to defeat the Chicago Cubs (12-9). The odds on this game have the Phillies at +126 while the Cubs are coming in at -152. The betting total is set at 9. The pitchers who are expected to start are Jesus Luzardo and Shota Imanaga.

Philadelphia is slugging .367 and have been called out on strikes 179 times, while drawing a walk on 67 occasions. They have tallied 74 runs batted in and 156 base knocks this year, while their average at the plate comes in at .222. The Phillies have earned 32 doubles as a team and have hit 22 baseballs out of the park. They have 75 runs and hold an on-base percentage of .302. As a squad, the Philadelphia Phillies are notching 3.6 runs per outing, which is 26th in the league.

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Their strikeout to walk ratio sits at 3.54 and the pitching staff sits with a WHIP of 1.41. Phillies pitchers have given up 20 home runs and 113 runs in total (28th in the league). Philadelphia has yielded 206 base hits (9.9 per 9 innings) and also 101 earned runs. The Phillies are sitting with a team ERA of 4.84 for the season (28th in baseball), and they have rung up 209 batters. They have walked 59 opposing batters and their FIP is 3.34 as a team for the year.

The Phillies relievers have recorded a save percentage of 83.3% and have come into the game in 16 save situations. They have recorded 5 saves over the course of the season and have blown 1 out of their 6 save opportunities. The bullpen pitchers have inherited 24 base runners for the season with 45.8% of those runners ended up crossing the plate. Phillies relief pitchers have stepped onto the hill with opponents on base 18 times as well as having 15 appearances in high leverage situations. The Phillies have dispatched 77 relievers to the hill this year. The relief pitchers have tallied 10 holds on the season (22nd in the league).

The Phillies have turned 63.0% of balls in play into outs out of 1,692 innings on the diamond, which has them sitting 30th in pro baseball. The Philadelphia Phillies have accumulated 564 putouts over the course of the season, in addition to 194 assists and 15 errors. Their fielding percentage is currently at .981 which has them sitting 26th in pro baseball, and they have turned 13 double plays.

Luzardo has taken the hill for 717 innings and has accumulated 805 punch outs so far in his MLB career. Luzardo (42-44 record in his career) has a FIP of 4.25 and he has faced 3,002 opposing batters in the majors. His earned run average is 4.32 (344 ER's allowed) and he has a WHIP of 1.252. He has surrendered 656 base knocks (8.2 hits per 9 innings) with 242 walks.

Chicago has knocked in 24 long balls so far this year to go along with 100 runs batted in. They have 31 two-baggers, while walking 95 times as well as putting up 112 runs. The Chicago Cubs have accounted for an OBP of .341 as well as a batting average of .251 for the season. The Cubs have a slugging percentage of .398 and they score 5.33 runs per outing (4th in baseball). They have struck out on 177 occasions (21st in the league) and have accounted for 179 hits.

The Cubs have a WHIP of 1.154 with a FIP of 4.04 as a unit over the course of the season. Their strikeout to walk ratio comes in at 8.50 (177 strikeouts against 62 walks). They have a ranking of 3rd in baseball as a pitching staff in total hits allowed with 155. They have given up 24 dingers and they allow 3.93 runs per 9 innings (10th in baseball). The Chicago pitching staff have conceded 82 runs for the season while having an ERA of 3.59 (75 earned runs yielded).

Chicago relief pitchers hold an inherited score percentage of 25.9% of 27 inherited runners. Their relief pitchers have stepped onto the mound 16 times in high leverage situations and on 21 occasions with base runners. With 9 save situations, the Cubs have tallied 3 holds in addition to 3 blown saves. They rank 22nd in the league holding a save percentage of 50.0%, and they have sent 64 bullpen pitchers onto the diamond this season.

In their 1,692 innings on the field, the Cubs are sitting with a defensive efficiency of 72.3% (3rd in MLB). The Chicago Cubs have turned 19 double plays and own a fielding percentage of .988 (11th in pro baseball). The Cubs have recorded 192 assists, 9 errors and have earned 564 putouts this season.

So far in his career, Imanaga has surrendered 278 hits and he has 322 K's in 340 innings pitched. He has surrendered 122 ER's while earning a WHIP of 0.991 and a FIP of 3.2. He has a K/BB ratio of 5.46 and he has gone up against 1,343 opposing hitters during his MLB career. Imanaga (25-12 career win-loss record) is the owner of a 3.23 earned run average and has allowed 7.4 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Philadelphia (+126)

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