Philadelphia Phillies vs Chicago Cubs Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: Philadelphia Phillies vs Chicago Cubs

Date: Wednesday, April 22, 2026

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Philadelphia (-144) Chicago (+120)

Wrigley Field is the site where the Chicago Cubs (13-9) will attempt to beat the Philadelphia Phillies (8-14) on Wednesday. The moneyline on this game has the Phillies at -144 while the Cubs open at +120. The total comes in at 9. The pitchers expected to start will be Taijuan Walker and Matthew Boyd.

Philadelphia is slugging .360 and have been called out on strikes 184 times, while being walked on 72 occasions. They have earned 75 runs batted in as well as 162 base knocks this year, while their batting average sits at .220. The Phillies have accumulated 33 doubles as a team and have knocked 22 balls out of the stadium. They are sitting with 76 runs while holding a team on-base percentage of .301. As a team, the Philadelphia Phillies are earning 3.5 runs per contest, which is 27th in baseball.

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They have earned a K/BB ratio of 3.42 and their pitching staff has earned a collective WHIP of 1.42. Phillies pitchers have yielded 21 home runs and 118 runs in total (28th in the league). Philadelphia has yielded 214 base hits (9.8 per 9 innings) and 106 earned runs. The Phillies are sitting with a team ERA of 4.87 on the season (28th in baseball), and their staff has struck out 219 batters. They have walked 64 opposing hitters and their FIP comes in at 3.38 as a unit this year.

The Phillies have dispatched 80 relief pitchers to the mound for the year. The relief pitchers have inherited 26 base runners on the campaign with 42.3% of those runners crossing the plate. The relief pitchers are sitting with 10 holds this season (22nd in baseball). Phillies pitchers have come into the game with opponents on base 19 times as well as having 15 appearances in high leverage situations. They have compiled 5 saves on the campaign and have missed out on 1 of their 6 save opportunities. The Phillies relief pitchers have accumulated a save percentage of 83.3% and stepped onto the hill in 16 save situations.

The Phillies have converted 63.1% of balls hit into play into outs out of their 1,764 innings, which has them ranked 30th in pro baseball. The Philadelphia Phillies have amassed 588 putouts thus far, as well as 200 assists and 15 errors. Their fielding percentage is currently at .981 which ranks 26th in baseball, and they have turned 14 double plays.

Walker has taken the hill for 1,296 innings and is sitting with 1,104 strikeouts during his career. His ERA is 4.26 (613 ER's allowed) and he has a WHIP of 1.298. He has allowed 1,239 base hits (8.6 hits per 9 innings) and has had 444 walks. Walker (78-74 career record) holds a FIP of 4.19 and he has faced 5,517 batters during his time in the majors.

The Chicago Cubs have accounted for a team OBP of .342 and a batting average of .251 on the campaign. They have been called out on strikes on 187 instances (15th in baseball) and have a total of 187 hits. Chicago has 25 home runs on the campaign and 104 runs batted in. The Cubs have a team slugging percentage of .399 and they tally 5.32 runs per game (5th in MLB). They have tallied 33 doubles, while getting a free base 100 times as well as putting up 117 runs.

The Cubs have a team WHIP of 1.157 in addition to having a FIP of 4.02 as a team on the year. They rank 3rd in MLB as a staff in total hits given up with 161. The Chicago pitching staff have surrendered 83 runs for the season while having an ERA of 3.47 (76 earned runs relinquished). They have earned a K/BB ratio of 8.30 (182 strikeouts vs 67 bases on balls). They have surrendered 24 home runs and they concede 3.79 runs per 9 innings (7th in MLB).

Chicago relief pitchers hold an inherited score rate of 25.0% out of 28 inherited runners. Their bullpen pitchers have stepped onto the mound 16 times in high leverage situations and on 22 occasions with runners on. With 9 save situations, the Cubs have accumulated 3 holds and also 3 blown saves. They are ranked 22nd in MLB holding a save percentage of 50.0%, and they have sent 66 relief pitchers to the hill this season.

In 1,773 innings played, the Cubs have accumulated a defensive efficiency of 72.6% (3rd in pro baseball). The Chicago Cubs have gotten 19 double plays and hold a fielding percentage of .988 (11th in pro baseball). The Cubs have 200 assists, 10 errors and have earned a total of 591 putouts on the campaign.

So far in his pro baseball career, Boyd has given up 1,061 hits and he has 1,062 K's in 1,097 frames. He has conceded a total of 560 ER's while earning a WHIP of 1.276 and a FIP of 4.5. He has a K/BB ratio of 3.13 and he has gone up against 4,651 hitters so far in his career. Boyd (61-78 win-loss mark in his career) has earned a 4.59 ERA while giving up 8.7 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Philadelphia (-144)

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