Philadelphia Phillies vs San Diego Padres Prediction, 5/25/2026 MLB Picks, Best Bets & Odds

Game: Philadelphia Phillies vs San Diego Padres

Date: Monday, May 25, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Philadelphia (-130) San Diego (+110)

The San Diego Padres (31-20) are hosting the Philadelphia Phillies (26-26) at Petco Park on Monday. The line on this matchup has the Phillies at -130 and the Padres are at +110. The total is 8. The starting pitchers are Jesus Luzardo and Randy Vasquez.

As a unit, the Philadelphia Phillies are scoring 4.1 runs per outing, which has them sitting at 22nd in the league. They have earned 212 runs scored and hold an OBP of .298. The Phillies have accumulated 72 doubles as a team and have knocked 62 balls out of the stadium. They have accumulated 208 RBI's in addition to 403 hits on the year, while their team batting average sits at .230. Philadelphia is slugging .386 and have been called out on strikes 434 times, while being walked on 155 occasions.

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They have a K/BB ratio of 3.40 and their pitching staff holds a WHIP of 1.33. Phillies pitchers have allowed 49 long balls and also 234 total runs (19th in MLB). Philadelphia has surrendered 473 hits (9.2 per 9 innings) and also 215 earned runs. The Phillies have a team earned run average of 4.16 on the season (18th in MLB), and their staff has rung up 493 batters. They have walked 145 hitters and their FIP comes in at 3.41 as a unit on the season.

Phillies pitchers have come into the game with runners on base 51 times in addition to having 47 appearances in high leverage situations. The bullpen have racked up 17 holds on the season (28th in baseball). The Phillies relief pitchers have earned a save percentage of 72.2% and have come into the game in 35 save situations. They have accumulated 13 saves on the year and have not converted 5 of 18 chances to get a save. The relief pitchers have inherited 63 runners this year and 33.3% of those runners crossing home plate. The Phillies have dispatched 177 relief pitchers to the hill this season.

The Philadelphia Phillies have earned a total of 1,396 putouts thus far, as well as 450 assists and 24 errors. Their fielding percentage is currently at .987 which puts them in 13th in pro baseball, and have accumulated 32 double plays. The Phillies have converted 66.0% of baseballs in play into outs out of 4,188 innings, ranking them 30th in baseball.

Luzardo has thrown 750 innings and has accumulated 841 punch outs in his career. His earned run average is 4.25 (354 earned runs allowed) and he has a career WHIP of 1.250. He has conceded 686 hits (8.2 hits per 9 innings) with 252 walks. Luzardo (44-45 career record) is the owner of a FIP of 4.18 and he has gone up against 3,140 opposing batters in the majors.

The Padres have a slugging percentage of .365 and they tally 4.10 runs per outing (20th in baseball). They have hit 73 doubles, while walking 166 times as well as racking up 209 runs. San Diego has tallied 52 long balls this year and 202 RBIs. They have struck out on 429 instances (18th in baseball) and have earned 363 hits. The San Diego Padres have recorded an OBP of .293 as well as a batting average of .219 this year.

The San Diego pitching staff have relinquished 200 runs on the year while holding an ERA of 3.84 (194 earned runs given up). They have relinquished 41 homers and they allow 3.96 runs per 9 innings (9th in the league). The Padres have a team WHIP of 1.251 and are the owners of a FIP of 3.63 as a squad on the season. Their strikeout to walk ratio sits at 8.70 (441 strikeouts against 177 walks). They are sitting at 7th in baseball as a staff in total hits allowed with 392.

They rank 8th in the league with a save percentage of 70.4%, and they have dispatched 171 relievers onto the diamond over the course of the season. Their bullpen pitchers have taken the field 57 times in high leverage situations in addition to 45 occasions with base runners. With 66 save situations, the Padres have accumulated 37 holds in addition to 8 blown saves. San Diego has had relief pitchers step onto the hill in 27 save opportunities and they have earned 19 saves. San Diego relief pitchers have an inherited score percentage of 33.8% of 80 inherited runners.

The San Diego Padres have turned 40 double plays and have accounted for a fielding rate of .991 (1st in baseball). The Padres have racked up 447 assists, 16 errors and have a total of 1,365 putouts this season. In 4,095 innings on the field, the Padres are sitting with a defensive efficiency of 70.5% (14th in baseball).

In his career, Vasquez has surrendered 323 base hits while totaling 218 K's in 323 frames. He has given up a total of 140 earned runs while holding a WHIP of 1.355 and a FIP of 3.8. His strikeout to walk ratio is 1.90 and he has gone up against 1,391 batters in his career. Vasquez (17-18 career record) holds a 3.90 earned run average while conceding 9.0 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Philadelphia (-130)

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