Pittsburgh Pirates vs Arizona Diamondbacks Prediction, 5/6/2026 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs Arizona Diamondbacks

Date: Wednesday, May 6, 2026

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Pittsburgh (-160) Arizona (+132)

Chase Field is where the Arizona Diamondbacks (16-17) will take on the Pittsburgh Pirates (19-16) on Wednesday. The moneyline on this contest has the Pirates at -160 and the Diamondbacks are sitting at +132. The total has been set at 8. The pitchers expected to start will be Paul Skenes and Michael Soroka.

Pittsburgh is slugging .393 and have struck out 327 times, while being walked on 143 occasions. They have accumulated 174 RBI's and 307 base knocks for the year, and their average at the plate is .253. The Pirates have earned 49 two-baggers as a team and have knocked 38 baseballs out of the park. They have accounted for 180 runs and have an OBP of .339. As a team, the Pittsburgh Pirates are compiling 5.1 runs per contest, which puts them at 6th in baseball.

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Their strikeout to walk ratio sits at 2.52 and their pitching staff sits with a WHIP of 1.23. Pirates pitchers have yielded 28 long balls and 149 runs (12th in MLB). Pittsburgh has conceded 263 hits (7.4 per 9 innings) and 132 earned runs. The Pirates have compiled a team ERA of 3.72 for the season (7th in the league), and their staff has struck out 330 batters. They have walked 131 opposing batters and their FIP comes in at 3.61 as a squad this season.

The Pirates bullpen have accumulated a save percentage of 38.5% and have come into the game in 37 save situations. They have earned 5 saves this season and have blown 8 of 13 save opportunities. The bullpen pitchers have inherited 38 runners for the season and 36.8% of those runners ended up scoring. Pirates relief pitchers have entered the game with runners on base 32 times as well as having 41 appearances in high leverage situations. The Pirates have dispatched 120 relief pitchers to the mound this year. The relievers have tallied 24 holds this year (9th in the league).

The Pittsburgh Pirates have notched a total of 958 putouts this season, in addition to 278 assists and 20 errors. Their fielding percentage is holding at .984 which has them sitting 25th in professional baseball, and have 24 double plays. The Pirates have converted 70.6% of balls hit into play into outs in their 2,874 innings, ranking them 11th in MLB.

Skenes (25-15 career win-loss record) sits with a FIP of 2.05 while he has gone up against 1,380 hitters during his time in the major leagues. He has allowed 252 base hits (6.4 hits per 9 innings) and has 81 walks. His ERA is 2.08 (82 earned runs allowed) and his career WHIP is 0.940. Skenes has thrown 354 innings and has accounted for 425 punch outs in his career.

Arizona has accounted for 34 home runs this season and 144 runs batted in. They have 60 two-baggers, while walking 87 times and recording 150 runs. The Arizona Diamondbacks have tallied a team on-base percentage of .304 as well as a team batting average of .247 this year. The Diamondbacks have a slugging percentage of .412 and they score 4.55 runs per game (11th in the league). They have been rung up on 267 occasions (28th in MLB) and have a total of 272 base hits.

The Diamondbacks are sitting with a team WHIP of 1.411 and have a FIP of 4.65 as a squad on the season. Their strikeout to walk ratio comes in at 7.50 (242 strikeouts against 116 free passes). They are currently ranked 20th in baseball as a pitching staff in total hits conceded with 292. They have surrendered 42 home runs and they yield 5.63 runs per 9 innings (28th in MLB). The Arizona pitching staff have yielded 181 runs on the season while holding an ERA of 5.07 (163 earned runs yielded).

They rank 20th in MLB with a save rate of 60.0%, and they have sent 119 bullpen pitchers onto the diamond on the season. Their relief pitchers have stepped onto the hill 45 times in high leverage situations in addition to 34 occasions with runners on. Sitting with 41 save situations, the Diamondbacks have tallied 25 holds and 6 blown saves. Arizona has called on bullpen pitchers to enter the game in 15 save opportunities and they have come away with 9 saves. Arizona bullpen pitchers hold an inherited score percentage of 26.5% out of their 49 inherited runners.

The Arizona Diamondbacks have gotten 21 double plays and have earned a fielding percentage of .985 (24th in professional baseball). The Diamondbacks have accrued 295 assists, 18 errors and have earned a total of 868 putouts so far this season. In 2,604 innings on the field, the Diamondbacks have earned a efficiency on defense of 69.5% (17th in professional baseball).

In his career, Soroka has surrendered 403 hits while he has totaled 415 punch outs in 445 frames. Soroka (24-27 career win-loss mark) has a 3.92 ERA while allowing 8.1 hits per nine innings. He has given up a total of 194 ER's while holding a WHIP of 1.239 and a FIP of 3.9. His K/BB ratio is 2.79 and he has gone up against 1,878 hitters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Pittsburgh (-160)

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