Pittsburgh Pirates vs Chicago Cubs Prediction, 4/10/2026 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs Chicago Cubs

Date: Friday, April 10, 2026

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Pittsburgh (-144) Chicago (+120)

The Pittsburgh Pirates (7-5) are hitting the road to Wrigley Field on Friday where they will compete against the Chicago Cubs (6-6). The moneyline on this matchup has the Pirates at -144 and the Cubs are coming in at +120. The total has been set at 9. The pitchers who are expected to start will be Carmen Mlodzinski and Shota Imanaga.

As a unit, the Pittsburgh Pirates are putting up 4.5 runs per game, which ranks them 13th in MLB. They have racked up 54 runs and have an OBP of .338. The Pirates have accrued 19 doubles as a unit and have hit 12 balls out of the park. They have amassed 54 RBI's in addition to 100 base knocks so far this season, while their team batting average is at .247. Pittsburgh is slugging .383 and have struck out 101 times, while taking a walk on 53 occasions.

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Their K/BB ratio is 2.31 and the pitching staff holds a WHIP of 1.30. Pirates pitchers have given up 9 long balls and also 48 runs in total (12th in MLB). Pittsburgh has surrendered 88 base knocks (7.3 per 9 innings) and also 40 earned runs. The Pirates have compiled a team earned run average of 3.33 on the year (8th in MLB), and their staff has struck out 120 batters. Their pitching staff has walked 52 opposing players and their FIP sits at 3.60 as a team on the season.

Pirates pitchers have entered the contest with runners on base 11 times as well as having 16 appearances in high leverage situations. The relievers have tallied 9 holds so far this year (9th in MLB). The Pirates relievers have recorded a save rate of 66.7% and have come into the game in 12 save situations. They have recorded 2 saves this season and have blown 1 of their 3 save chances. The relievers have inherited 15 base runners for the season and 13.3% of those players ended up scoring. The Pirates have dispatched 43 relievers to the hill so far this year.

The Pirates have converted 69.8% of baseballs in play into outs out of their 972 innings, which has them ranked 14th in baseball. The Pittsburgh Pirates have accumulated 324 putouts this season, in addition to 88 assists and 6 errors. Their fielding rate is holding steady at .986 which ranks 15th in professional baseball, and they have turned 9 double plays.

Mlodzinski has pitched in 194 frames and has earned 182 K's during his MLB career. Mlodzinski (13-16 career win-loss mark) is the owner of a FIP of 3.24 and he has faced 821 hitters during his time in the majors. His earned run average is 3.29 (71 earned runs allowed) and he has a WHIP of 1.282. He has surrendered 182 hits (8.4 hits per nine innings) with 67 walks.

The Cubs have a team SLG% of .368 and they are earning 4.67 runs per contest (10th in MLB). They have 18 two-baggers, while walking 51 times as well as putting up 56 runs. Chicago has accounted for 13 home runs on the campaign as well as 51 RBIs. They have been called out on strikes on 102 instances (17th in baseball) and have recorded 87 hits. The Chicago Cubs have a team OBP of .312 as well as a team batting average of .223 so far this season.

The Cubs have a team WHIP of 1.124 and are the owners of a FIP of 4.30 as a unit on the campaign. Their strikeout to walk ratio comes in at 7.90 (92 strikeouts against 39 bases on balls). They come in at 4th in the league as a pitching staff in total hits conceded with 79. They have given up 13 homers and they allow 3.77 runs per 9 innings (10th in baseball). The Chicago pitching staff have allowed 44 runs on the campaign while having a team ERA of 3.43 (40 earned runs surrendered).

Chicago relief pitchers hold an inherited score rate of 31.8% out of their 22 inherited base runners. Their relief pitchers have taken the field 10 times in high leverage situations and also on 13 occasions with runners on base. Sitting with 6 save situations, the Cubs have accrued 1 hold in addition to 3 blown saves. They are ranked 27th in the league holding a save percentage of 40.0%, and they have sent 36 relievers to the mound on the year.

The Chicago Cubs have turned 9 double plays and have a fielding rate of .991 (8th in baseball). The Cubs have accrued 112 assists, 4 errors and have earned a total of 315 putouts on the season. In their 945 innings on the field, the Cubs have accumulated a efficiency on defense of 75.1% (2nd in pro baseball).

Imanaga (24-12 career mark) is the owner of a 3.32 ERA and has surrendered 7.5 hits per 9 innings. His strikeout to walk ratio is 5.30 and he has gone up against 1,302 batters during his career. He has given up a total of 121 earned runs while holding a WHIP of 1.012 and being the owner of a FIP of 3.3. In his career, Imanaga has allowed 275 base knocks while he has accumulated 302 strikeouts in 328 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Pittsburgh (-144)

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