Pittsburgh Pirates vs Chicago White Sox Prediction, 9/10/2026 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs Chicago White Sox

Date: Thursday, September 10, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Pittsburgh (-145) Chicago (+125)

Rate Field is the site where the Chicago White Sox (75-68) will try to beat the Pittsburgh Pirates (71-73) on Thursday. The moneyline on this game has the Pirates at -145 and the White Sox are at +125. The betting total is set at 8.5. The starting pitchers will be Jared Jones and Luis Castillo.

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Pittsburgh is slugging .401 and have been rung up 1,362 times, while taking a walk on 513 occasions. They have 661 runs batted in as well as 1,245 base knocks over the course of the season, while their team batting average is sitting at .252. The Pirates have compiled 215 doubles as a unit and have hit 165 balls out of the park. They have notched a total of 694 runs scored and have an on-base percentage of .330. As a unit, the Pittsburgh Pirates are putting up 4.8 runs per game, which has them sitting at 5th in the league.

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They have a K/BB ratio of 2.51 and the pitching staff has a collective WHIP of 1.31. Pirates pitchers have relinquished 139 home runs and also 668 total runs (20th in the league). Pittsburgh has yielded 1,153 base hits (8.1 per 9 innings) as well as 597 earned runs. The Pirates have an earned run average of 4.18 this season (17th in baseball), and their staff has struck out 1,322 hitters. They have walked 527 opposing hitters and their FIP comes in at 3.85 as a unit so far this year.

The Pirates have sent 468 relief pitchers to the hill this year. The bullpen pitchers have inherited 175 runners for the season and 32.6% of those runners ended up scoring. The relief pitchers have earned 64 holds over the course of the season (26th in the league). Pirates relief pitchers have stepped onto the hill with runners on 121 times in addition to having 134 appearances in high leverage situations. They have recorded 31 saves on the season and have blown 22 of 53 save chances. The Pirates relievers have compiled a save rate of 58.5% and have entered the game in 119 save situations.

The Pirates have turned 68.9% of balls hit into play into outs out of 11,577 innings, ranking them 26th in baseball. The Pittsburgh Pirates have 3,859 putouts at this point in the season, in addition to 1,144 assists and 90 errors. Their fielding rate sits at .982 which has them ranked 26th in professional baseball, and they have turned 116 double plays.

Jones (9-14 career mark) sits with a FIP of 4.22 while he has faced 837 opposing hitters during his time in the major leagues. He has given up 175 hits (7.9 hits per 9 innings) and has 67 free passes. His earned run average is 4.29 (95 earned runs allowed) and his WHIP is 1.214. Jones has thrown 199 frames and has accumulated 224 K's during his career.

The White Sox have a SLG% of .407 and they earn 4.76 runs per contest (6th in baseball). They have hit 227 two-baggers, while getting a free base 517 times and scoring 680 runs. Chicago has tallied 188 home runs for the season as well as 649 RBIs. They have struck out on 1,303 instances (6th in baseball) and are sitting with 1,136 base hits. The Chicago White Sox are sitting with an OBP of .319 in addition to a team batting average of .237 on the campaign.

The Chicago pitching staff have relinquished 631 runs this season while holding an ERA of 4.11 (582 earned runs conceded). They have conceded 161 dingers and they concede 4.46 runs per 9 innings (14th in the league). The White Sox hold a team WHIP of 1.303 and have a FIP of 4.27 as a pitching staff over the course of the season. They have earned a K/BB ratio of 8.40 (1,192 strikeouts vs 514 walks). They rank 11th in the league as a staff in total hits allowed with 1,146.

Chicago bullpen pitchers hold an inherited score percentage of 29.8% out of their 228 inherited base runners. Their bullpen pitchers have stepped onto the mound 142 times in high leverage situations and also on 156 occasions with runners on. Sitting with 121 save situations, the White Sox have earned 55 holds and 26 blown saves. They are currently ranked 20th in baseball with a save rate of 58.7%, and they have sent 476 bullpen pitchers to the hill this year.

The Chicago White Sox have gotten 95 double plays and own a fielding percentage of .986 (16th in MLB). The White Sox have recorded 1,160 assists, 73 errors and are sitting with 3,822 putouts so far this season. Out of their 11,466 innings on the field, the White Sox are sitting with a defensive efficiency of 70.6% (12th in MLB).

During his MLB career, Castillo has allowed 1,245 base knocks while he has earned 1,516 punch outs in 1,436 innings. He has given up 579 earned runs while earning a WHIP of 1.188 and having a FIP of 3.6. His strikeout to walk ratio is 3.29 and he has faced 5,948 batters thus far in his career. Castillo (85-86 career mark) has earned a 3.63 earned run average and has given up 7.8 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Pittsburgh (-145)

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