Pittsburgh Pirates vs Milwaukee Brewers Prediction, 4/25/2026 MLB Picks, Best Bets & Odds
Game: Pittsburgh Pirates vs Milwaukee Brewers
Date: Saturday, April 25, 2026
Location: American Family Field in Milwaukee, WI
TV: Brewers.TV
Odds/Point Spread: Pittsburgh (+110) Milwaukee (-130)
The Pittsburgh Pirates (14-11) are on their way to American Family Field on Saturday where they will take on the Milwaukee Brewers (13-11). The moneyline on this contest has the Pirates at +110 and the Brewers are at -130. The total comes in at 9. The expected starting pitchers will be Mitch Keller and Jacob Misiorowski.

Pittsburgh has a slugging percentage of .386 and have struck out 233 times, while drawing a walk on 99 occasions. They have tallied 119 RBI's in addition to 214 base knocks on the year, and their team batting average is at .247. The Pirates have earned 33 doubles as a squad and have hit 28 baseballs out of the stadium. They have tallied 123 runs while holding a team OBP of .332. As a squad, the Pittsburgh Pirates are knocking in 4.9 runs per contest, which puts them at 8th in the league.
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The Pirates have a team earned run average of 3.45 so far this year (6th in the league), and the staff has rung up 234 hitters. Pirates pitchers have yielded 19 home runs and also 103 runs in total (12th in the league). Their pitching staff has walked 103 hitters and their FIP is 3.70 as a squad so far this season. Pittsburgh has yielded 193 hits (7.6 per 9 innings) as well as 88 earned runs. They have a K/BB ratio of 2.27 and their pitching staff has earned a collective WHIP of 1.29.
The Pirates have sent 88 relief pitchers to the hill so far this season. The bullpen pitchers have inherited 24 runners on the year and 29.2% of them crossing the plate. The relievers have racked up 20 holds on the season (4th in MLB). Pirates relief pitchers have come into the game with players on base 22 times and also have had 34 appearances in high leverage situations. They have earned 4 saves this season and have blown 6 of their 10 save opportunities. The Pirates relief pitchers have a save percentage of 40.0% and have entered the game in 30 save situations.
The Pittsburgh Pirates have 688 putouts on the campaign, in addition to 201 assists and 14 errors. Their fielding rate is holding at .984 which ranks 19th in MLB, and have accumulated 19 double plays. The Pirates have turned 70.0% of balls hit into play into outs out of 2,064 innings, which has them sitting 17th in professional baseball.
Keller has taken the hill for 907 innings and is sitting with 856 K's during his pro baseball career. Keller (44-66 mark in his career) has a FIP of 4.39 while he has gone up against 3,933 hitters in the majors. His earned run average is 4.46 (449 earned runs allowed) and he has a WHIP of 1.373. He has allowed 937 base knocks (9.3 hits per nine innings) and has 308 free passes.
The Brewers hold a team slugging % of .365 and they have an average of 5.17 runs per game (6th in baseball). They have notched 35 doubles, while getting a free base 119 times as well as notching 124 runs. Milwaukee has accounted for 19 long balls for the year to go along with 119 RBIs. They have struck out on 198 occasions (23rd in the league) and have 192 hits. The Milwaukee Brewers have compiled an on-base percentage of .341 and a team batting average of .240 for the season.
The Milwaukee pitching staff have yielded 101 runs on the campaign while holding an ERA of 3.99 (94 earned runs relinquished). They have surrendered 23 home runs and they relinquish 4.29 runs per 9 innings (12th in MLB). The Brewers hold a team WHIP of 1.334 in addition to having a FIP of 3.97 as a staff so far this season. Their strikeout to walk ratio sits at 9.00 (212 strikeouts against 91 bases on balls). They sit at 10th in MLB as a staff in total hits relinquished with 192.
Milwaukee bullpen pitchers have an inherited score percentage of 40.0% of 40 inherited base runners. Their relief pitchers have taken the field 29 times in high leverage situations and on 24 occasions with runners on. With 29 save situations, the Brewers have 16 holds in addition to 5 blown saves. They are currently ranked 18th in baseball with a save rate of 61.5%, and they have sent 84 relievers onto the field so far this year.
In 1,911 innings on the diamond, the Brewers have accumulated a defensive efficiency of 69.3% (21st in professional baseball). The Milwaukee Brewers have turned 18 double plays and have notched a fielding percentage of .989 (6th in professional baseball). The Brewers have racked up 208 assists, 9 errors and have a total of 637 putouts during this campaign.
In his MLB career, Misiorowski has given up 68 base knocks while he has totaled 129 punch outs in 92 innings pitched. Misiorowski (6-5 career mark) has a 4.00 earned run average while giving up 6.6 hits per nine innings. He has given up 41 ER's while holding a WHIP of 1.204 and having a FIP of 3.9. He has a strikeout to walk ratio of 3.00 and he has faced 384 hitters so far in his pro baseball career.
Who will win tonight's MLB game against the spread or moneyline?
Josh Schonwald's Pick: Take Milwaukee (-130)
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Additional Resources:
Milwaukee Brewers - Twitter
Pittsburgh Pirates - Twitter
