Pittsburgh Pirates vs New York Yankees Prediction, 7/22/2026 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs New York Yankees

Date: Wednesday, July 22, 2026

Location: Yankee Stadium in Bronx, NY

TV: YES

Odds/Point Spread: Pittsburgh (+102) New York (-122)

The Pittsburgh Pirates (52-49) are en route to Yankee Stadium on Wednesday where they will try to beat the New York Yankees (56-44). The odds on this game have the Pirates at +102 while the Yankees are sitting at -122. The over/under is set at 9. The pitchers taking the mound are Mitch Keller and Gerrit Cole.

Pittsburgh is slugging .427 and have been rung up 956 times, while being walked on 376 occasions. They have 514 runs batted in as well as 923 base knocks for the season, while their batting average is at .263. The Pirates have hit 164 doubles as a unit and have hit 130 balls out of the park. They have earned 538 runs and hold an on-base percentage of .341. As a team, the Pittsburgh Pirates are putting up 5.3 runs per outing, which has them sitting at 2nd in the league.

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They have accumulated a K/BB ratio of 2.55 and their pitching staff has a team WHIP of 1.32. Pirates pitchers have given up 106 home runs and also 487 total runs (23rd in the league). Pittsburgh has yielded 822 base knocks (8.2 per 9 innings) and 430 earned runs. The Pirates hold a team earned run average of 4.30 on the year (20th in the league), and the staff has struck out 925 hitters. They have walked 363 opposing players and their FIP comes in at 3.98 as a unit so far this year.

The Pirates have dispatched 322 relief pitchers to the hill so far this year. The bullpen pitchers have inherited 129 runners on the campaign and 31.0% of those players crossing home plate. The relief pitchers have notched 47 holds this year (21st in MLB). Pirates relief pitchers have come into the game with opponents on base 90 times in addition to having 92 appearances in high leverage situations. They have earned 19 saves for the year and have blown 18 of 37 chances to save the game. The Pirates relief pitchers have a save percentage of 51.4% and have entered the game in 85 save situations.

The Pittsburgh Pirates have accumulated 2,703 putouts this year, as well as 798 assists and 60 errors. Their fielding rate is currently at .983 which ranks 22nd in pro baseball, and have a total of 79 double plays. The Pirates have converted 68.9% of baseballs in play into outs out of 8,109 innings, which has them ranked 24th in MLB.

Keller has taken the hill for 981 innings and has totaled 914 strikeouts in his MLB career. His ERA is 4.58 (499 earned runs allowed) and he has a WHIP of 1.376. He has surrendered 1,016 hits (9.3 hits per nine innings) with 334 free passes. Keller (48-72 career mark) has a FIP of 4.51 while facing 4,261 hitters during his time in the major leagues.

New York has a total of 146 HRs for the year to go along with 452 runs batted in. They have notched 150 doubles, while getting a free base 375 times as well as putting up 475 runs. The New York Yankees are sitting with a team OBP of .316 as well as a batting average of .237 on the campaign. The Yankees hold a slugging percentage of .423 and they earn 4.75 runs per game (10th in MLB). They have struck out on 899 occasions (5th in baseball) and have 784 base hits.

The Yankees hold a team WHIP of 1.193 in addition to having a FIP of 3.76 as a team so far this year. Their strikeout to walk ratio sits at 8.90 (873 strikeouts vs 302 walks). They are currently ranked 4th in baseball as a staff in total hits conceded with 756. They have surrendered 100 HR's and they give up 3.93 runs per 9 innings (5th in baseball). The New York pitching staff have given up 387 runs over the course of the season while holding a team ERA of 3.42 (337 earned runs surrendered).

They are currently ranked 20th in MLB holding a save percentage of 60.0%, and they have sent 332 relievers to the hill so far this year. Their bullpen pitchers have stepped onto the mound 107 times in high leverage situations and on 114 occasions with runners on base. With 90 save situations, the Yankees have 49 holds and 16 blown saves. New York has called on bullpen pitchers to take the mound in 40 save chances and they have come away with 24 saves. New York bullpen pitchers have an inherited score percentage of 25.4% out of their 169 inherited base runners.

The New York Yankees have gotten 72 double plays and have a fielding percentage of .984 (20th in pro baseball). The Yankees have racked up 869 assists, 57 errors and have notched a total of 2,663 putouts during this campaign. In 7,989 innings played, the Yankees have earned a defensive efficiency of 71.0% (7th in professional baseball).

Cole (156-85 career win-loss record) has a 3.20 earned run average and has given up 7.5 hits per nine innings. His K/BB ratio is 4.50 and he has faced 8,091 batters in his career. He has conceded 714 earned runs while earning a WHIP of 1.091 and having a FIP of 3.2. In his MLB career, Cole has allowed 1,679 base hits while he has earned 2,306 punch outs in 2,009 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Pittsburgh (+102)

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