Pittsburgh Pirates vs San Diego Padres Prediction, 8/25/2026 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs San Diego Padres

Date: Tuesday, August 25, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Pittsburgh (+150) San Diego (-182)

The Pittsburgh Pirates (63-69) are en route to Petco Park on Tuesday where they will meet the San Diego Padres (71-60). The moneyline on this matchup has the Pirates at +150 and the Padres are at -182. The over/under is set at 8. The pitchers who are expected to start are Paul Skenes and Michael King.

As a unit, the Pittsburgh Pirates are putting up 5.0 runs per contest, which has them sitting at 5th in the league. They have accumulated 653 runs scored and hold an on-base percentage of .331. The Pirates have accounted for 202 two-baggers as a team and have hit 156 baseballs out of the stadium. They have accumulated 623 RBI's in addition to 1,152 base knocks so far this season, while their average at the plate is sitting at .254. Pittsburgh has a slugging rate of .407 and have struck out 1,247 times, while being walked on 468 occasions.

Get all of our Free MLB Picks

The Pirates have compiled a team earned run average of 4.29 this season (22nd in MLB), and the staff has rung up 1,226 hitters. Pirates pitchers have conceded 134 home runs and 628 runs in total (23rd in the league). They have walked 487 players from the other team and their FIP sits at 3.91 as a team for the year. Pittsburgh has conceded 1,070 base hits (8.2 per 9 innings) and 561 earned runs. They have earned a strikeout to walk ratio of 2.52 and their pitching staff holds a collective WHIP of 1.32.

Pirates bullpen pitchers have come into the game with runners on 107 times as well as having 112 appearances in high leverage situations. The bullpen have tallied 50 holds over the course of the season (29th in MLB). The Pirates relief pitchers have recorded a save rate of 55.6% and have come into the game in 96 save situations. They have recorded 25 saves so far this year and have not converted 20 out of their 45 save opportunities. The bullpen pitchers have inherited 151 runners so far this year with 34.4% of them ended up crossing the plate. The Pirates have dispatched 421 relievers to the mound on the year.

The Pittsburgh Pirates are sitting with 3,529 putouts for the season, as well as 1,032 assists and 83 errors. Their fielding percentage is at .982 which puts them in 27th in professional baseball, and they have turned 107 double plays. The Pirates have converted 68.6% of balls hit into play into outs out of 10,587 innings on the field, ranking them 27th in the majors.

Skenes has pitched in 459 frames and has 557 strikeouts in his career. His ERA is 2.57 (131 earned runs allowed) and he has a WHIP of 1.008. He has surrendered 348 hits (6.8 hits per 9 innings) and has 115 walks. Skenes (30-24 career win-loss record) holds a FIP of 2.53 while facing 1,820 opposing hitters in the majors.

The San Diego Padres are sitting with a team OBP of .316 as well as a batting average of .239 on the campaign. They have been rung up on 1,061 instances (20th in MLB) and have 1,030 hits. San Diego has accumulated 148 home runs so far this year as well as 544 runs batted in. The Padres have a SLG% of .391 and they earn 4.31 runs per game (21st in MLB). They have tallied 191 two-baggers, while taking a walk 454 times and earning 564 runs.

The Padres hold a team WHIP of 1.294 and have a FIP of 4.17 as a team this year. They rank 15th in the league as a pitching staff in total hits allowed with 1,053. The San Diego pitching staff have conceded 548 runs on the year while holding an ERA of 4.01 (516 earned runs relinquished). They currently have a K/BB ratio of 8.20 (1,052 strikeouts against 444 walks). They have allowed 144 homers and they surrender 4.26 runs per 9 innings (9th in baseball).

Sitting with 137 save situations, the Padres have tallied 80 holds in addition to 15 blown saves. San Diego has had relievers step onto the mound in 54 save chances and they have recorded 39 saves. San Diego bullpen pitchers hold an inherited score percentage of 31.9% out of 207 inherited runners. Their relievers have stepped onto the hill 142 times in high leverage situations in addition to 123 occasions with base runners. They are ranked 6th in baseball with a save percentage of 72.2%, and they have dispatched 436 relief pitchers onto the diamond so far this season.

The San Diego Padres have gotten 106 double plays and have accounted for a fielding rate of .988 (5th in professional baseball). The Padres have racked up 1,152 assists, 55 errors and have earned 3,471 putouts so far this season. In their 10,413 innings on the field, the Padres have earned a efficiency on defense of 70.5% (11th in pro baseball).

So far in his MLB career, King has allowed 535 base hits while earning 687 punch outs in 643 innings. King (39-38 win-loss record in his career) holds a 3.27 ERA and has allowed 7.5 hits per 9 innings. He has surrendered a total of 234 earned runs while holding a WHIP of 1.189 and being the owner of a FIP of 3.2. He has a strikeout to walk ratio of 2.99 and he has gone up against 2,679 opposing batters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (-182)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.