Pittsburgh Pirates vs San Diego Padres Prediction, 8/26/2026 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs San Diego Padres

Date: Wednesday, August 26, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Pittsburgh (+120) San Diego (-144)

The San Diego Padres (71-61) will try to defeat the Pittsburgh Pirates (64-69) at Petco Park on Wednesday. The line on this matchup has the Pirates at +120 and the Padres are coming in at -144. The over/under comes in at 9. The pitchers taking the mound are Bubba Chandler and Randy Vasquez.

The Pirates have accounted for 203 two-baggers as a team and have smacked 157 balls out of the stadium. Pittsburgh has a slugging % of .406 and have been rung up 1,262 times, while drawing a walk on 473 occasions. As a team, the Pittsburgh Pirates are putting up 4.9 runs/g, which is 5th in the league. They have 626 runs batted in as well as 1,161 base knocks so far this year, while their team batting average is sitting at .253. They have 656 runs scored while holding a team on-base percentage of .330.

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They have accumulated a K/BB ratio of 2.51 and the pitching staff holds a collective WHIP of 1.32. Pirates pitchers have given up 134 home runs and also 630 total runs (23rd in baseball). Pittsburgh has surrendered 1,077 base hits (8.2 per 9 innings) and 563 earned runs. The Pirates are sitting with a team ERA of 4.26 on the campaign (22nd in baseball), and the staff has struck out 1,236 hitters. They have walked 493 players from the other team and their FIP is 3.90 as a unit for the year.

The Pirates relievers have compiled a save rate of 55.3% and have come into the game in 99 save situations. They have recorded 26 saves on the campaign and have blown 21 of their 47 save chances. The bullpen pitchers have inherited 154 runners this season and 33.8% of those players ended up crossing the plate. Pirates pitchers have come into the game with runners on base 111 times and also have had 118 appearances in high leverage situations. The Pirates have dispatched 427 relief pitchers to the mound this year. The relief pitchers have recorded 51 holds for the year (28th in the league).

The Pirates have transformed 68.6% of balls in play into outs out of their 10,695 innings, which ranks them 27th in the majors. The Pittsburgh Pirates have accounted for 3,565 putouts at this point in the season, as well as 1,045 assists and 83 errors. Their fielding percentage is holding at .982 which has them ranked 27th in professional baseball, and have earned 111 double plays.

Chandler has taken the hill for 156 frames and has racked up 145 strikeouts so far in his pro baseball career. His earned run average is 4.32 (75 ER's allowed) and his WHIP is 1.287. He has conceded 131 base hits (7.5 hits per 9 innings) and has 70 walks. Chandler (10-9 mark in his career) has earned a FIP of 4.26 while he has faced 671 opposing batters in the majors.

The San Diego Padres have recorded a team on-base percentage of .316 and a team batting average of .238 on the season. They have been rung up on 1,071 occasions (19th in the league) and have earned 1,037 hits. San Diego has knocked in 148 long balls so far this season and 545 runs batted in. The Padres have a slugging percentage of .390 and they have an average of 4.29 runs per outing (21st in the league). They have recorded 193 doubles, while taking a walk 460 times and putting up 566 runs.

The Padres have a team WHIP of 1.293 with a FIP of 4.16 as a squad on the campaign. Their strikeout to walk ratio sits at 8.20 (1,067 strikeouts vs 449 walks). They are currently ranked 15th in MLB as a pitching staff in total hits allowed with 1,062. They have allowed 145 homers and they concede 4.24 runs per 9 innings (9th in MLB). The San Diego pitching staff have surrendered 551 runs on the campaign while having a team ERA of 3.99 (518 earned runs yielded).

With 137 save situations, the Padres have earned 80 holds in addition to 15 blown saves. San Diego has had bullpen pitchers step onto the mound in 54 save chances and they have earned 39 saves. San Diego bullpen pitchers have an inherited score percentage of 32.2% out of 208 inherited runners. Their relief pitchers have taken the field 145 times in high leverage situations and on 126 occasions with runners on base. They are currently ranked 6th in the league with a save percentage of 72.2%, and they have sent 442 relievers to the hill this year.

The San Diego Padres have turned 107 double plays and have a fielding percentage of .988 (5th in baseball). The Padres have recorded 1,166 assists, 55 errors and have amassed 3,507 putouts during this campaign. In 10,521 innings played, the Padres have a defensive efficiency of 70.6% (10th in pro baseball).

Vasquez (21-22 career win-loss record) has a 4.12 ERA while allowing 9.2 hits per nine innings. He has a strikeout to walk ratio of 1.89 and he has gone up against 1,665 hitters thus far in his career. He has allowed 177 ER's while holding a WHIP of 1.364 and a FIP of 4.1. During his MLB career, Vasquez has surrendered 397 hits while he has tallied 247 strikeouts in 387 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Pittsburgh (+120)

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