Pittsburgh Pirates vs San Francisco Giants Prediction, 5/10/2026 MLB Picks, Best Bets & Odds

Game: Pittsburgh Pirates vs San Francisco Giants

Date: Sunday, May 10, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Pittsburgh (-128) San Francisco (+106)

The Pittsburgh Pirates (21-17) are hitting the road to Oracle Park on Sunday where they will take on the San Francisco Giants (14-23). The line on this matchup has Pittsburgh at -128 and San Francisco is at +106. The betting total comes in at 9. The pitchers who are expected to start are Bubba Chandler and Tyler Mahle.

Pittsburgh has a slugging percentage of .387 and have been rung up 351 times, while drawing a walk on 151 occasions. They have 179 runs batted in in addition to 323 hits this season, while their average at the plate comes in at .246. The Pirates have hit 51 doubles as a squad and have smacked 41 baseballs out of the stadium. They have a total of 185 runs and have an OBP of .332. As a squad, the Pittsburgh Pirates are notching 4.9 runs per game, which is 8th in the league.

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The Pirates have a team earned run average of 3.70 so far this season (7th in MLB), and their staff has struck out 348 hitters. Pirates pitchers have surrendered 29 home runs in addition to 160 total runs (12th in the league). They have walked 143 opposing hitters and their FIP comes in at 3.62 as a squad this season. Pittsburgh has surrendered 278 base hits (7.3 per 9 innings) and 142 earned runs. They have earned a K/BB ratio of 2.43 and their pitching staff sits with a WHIP of 1.22.

The Pirates relief pitchers have recorded a save rate of 46.7% and stepped onto the hill in 42 save situations. They have tallied 7 saves on the year and have blown 8 out of their 15 chances to save the game. The relief pitchers have inherited 43 base runners so far this year and 34.9% of those players ended up scoring. Pirates pitchers have come into the game with runners on base 35 times as well as having 46 appearances in high leverage situations. The Pirates have sent 128 relievers to the mound this season. The bullpen have recorded 27 holds on the year (4th in baseball).

The Pittsburgh Pirates have earned a total of 1,036 putouts this year, as well as 303 assists and 21 errors. Their fielding percentage is currently at .985 which has them ranked 24th in baseball, and have a total of 27 double plays. The Pirates have transformed 71.2% of balls hit into play into outs in their 3,108 innings, which has them sitting 6th in the majors.

Chandler (5-5 career win-loss mark) holds a FIP of 4.36 while he has gone up against 276 opposing hitters in the majors. He has given up 50 base hits (6.9 hits per nine innings) and has 30 free passes. His ERA is 4.42 (32 earned runs allowed) and he has a WHIP of 1.229. Chandler has pitched in 65 frames and has 62 K's so far in his pro baseball career.

The Giants have a team slugging % of .355 and they score 3.11 runs per outing (30th in the league). They have hit 62 doubles, while taking a walk 72 times and putting up 115 runs. San Francisco is sitting with 23 home runs for the year and 110 RBIs. They have been rung up on 293 occasions (25th in the league) and have notched a total of 295 hits. The San Francisco Giants have earned an OBP of .282 and a team batting average of .238 on the year.

The San Francisco pitching staff have given up 157 runs for the season while having an ERA of 3.96 (144 earned runs yielded). They have given up 37 long balls and they surrender 4.32 runs per 9 innings (11th in baseball). The Giants hold a team WHIP of 1.296 in addition to having a FIP of 4.13 as a pitching staff over the course of the season. Their strikeout to walk ratio comes in at 8.10 (295 strikeouts vs 136 free passes). They are currently ranked 9th in the league as a staff in total hits relinquished with 288.

San Francisco bullpen pitchers have an inherited score percentage of 31.1% of 45 inherited runners. Their relief pitchers have come in 19 times in high leverage situations and also on 31 occasions with runners on base. With 33 save situations, the Giants have 21 holds and also 5 blown saves. They rank 20th in baseball with a save rate of 58.3%, and they have dispatched 116 relief pitchers to the mound this year.

The San Francisco Giants have gotten 37 double plays and hold a fielding percentage of .985 (20th in MLB). The Giants have accrued 369 assists, 20 errors and have a total of 982 putouts this year. In 2,946 innings on the diamond, the Giants are sitting with a defensive efficiency of 70.8% (9th in pro baseball).

So far in his MLB career, Mahle has surrendered 718 base knocks while he has accumulated 787 K's in 771 innings. He has given up a total of 352 ER's while earning a WHIP of 1.297 and having a FIP of 4.0. His strikeout to walk ratio is 2.79 and he has gone up against 3,280 opposing hitters in his career. Mahle (40-50 win-loss record in his career) has earned a 4.11 earned run average and has surrendered 8.4 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Pittsburgh (-128)

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