San Diego Padres vs Arizona Diamondbacks Prediction, 4/25/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Arizona Diamondbacks

Date: Saturday, April 25, 2026

Location: Estadio Alfredo Harp Helú in Mexico City, MX

TV: DBACKS.TV

Odds/Point Spread: San Diego (-130) Arizona (+110)

The Arizona Diamondbacks (14-11) welcome the San Diego Padres (17-8) at Estadio Alfredo Harp Helú on Saturday. The line on this contest has the Padres at -130 and the Diamondbacks are coming in at +110. The over/under is set at 9. The starting pitchers will be German Marquez and Zac Gallen.

The Padres have accumulated 49 doubles as a squad and have knocked 20 balls out of the stadium. San Diego owns a slugging percentage of .372 and have been called out on strikes 206 times, while being walked on 87 occasions. As a squad, the San Diego Padres are knocking in 4.4 runs per game, which has them at 16th in MLB. They have earned 105 runs batted in as well as 194 hits this season, while their batting average is .234. They have earned a total of 110 runs scored while holding a team on-base percentage of .310.

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They have a K/BB ratio of 2.77 and the pitching staff holds a collective WHIP of 1.26. Padres pitchers have conceded 16 long balls and also 95 runs in total (5th in baseball). San Diego has given up 200 base knocks (8.0 per 9 innings) and 90 earned runs. The Padres have an ERA of 3.62 on the season (9th in MLB), and their staff has struck out 230 batters. They have walked 83 players from the other team and their FIP sits at 3.32 as a team this year.

The Padres have sent 85 relievers to the mound for the season. The relief pitchers have inherited 42 runners so far this year and 38.1% of them ended up scoring. The relief pitchers have tallied 19 holds so far this year (6th in the league). Padres relief pitchers have entered the contest with players on base 23 times in addition to having 28 appearances in high leverage situations. They have earned 11 saves on the campaign and have not converted 5 of their 16 save opportunities. The Padres bullpen have a save percentage of 68.8% and stepped onto the hill in 37 save situations.

The San Diego Padres have a total of 672 putouts on the campaign, as well as 213 assists and 6 errors. Their fielding rate is currently at .993 which ranks 2nd in pro baseball, and have earned 22 double plays. The Padres have turned 68.7% of balls hit into play into outs out of their 2,016 innings, which ranks them 22nd in baseball.

Marquez has taken the ball for 1,164 innings and has racked up 1,084 strikeouts so far in his career. His earned run average is 4.66 (603 ER's allowed) and he has a career WHIP of 1.336. He has surrendered 1,195 hits (9.2 hits per 9 innings) with 360 walks. Marquez (70-73 win-loss mark in his career) has earned a FIP of 4.59 and he has gone up against 4,986 hitters during his time in the majors.

The Arizona Diamondbacks have accumulated an OBP of .306 as well as a team batting average of .251 on the campaign. They have been called out on strikes on 197 occasions (24th in the league) and have earned a total of 208 base hits. Arizona has hit 23 HRs for the year to go along with 110 RBIs. The Diamondbacks hold a team slugging percentage of .417 and they are earning 4.64 runs per outing (13th in MLB). They have put up 51 two-baggers, while taking a walk 65 times and notching 116 runs.

The Diamondbacks have a WHIP of 1.324 with a FIP of 4.50 as a unit for the season. They currently have a strikeout to walk ratio of 7.60 (188 strikeouts vs 79 bases on balls). They rank 25th in baseball as a staff in total hits given up with 215. They have surrendered 32 home runs and they concede 5.02 runs per 9 innings (22nd in baseball). The Arizona pitching staff have given up 124 runs this season while having a team ERA of 4.42 (109 earned runs relinquished).

They sit at 14th in baseball with a save percentage of 64.3%, and they have dispatched 89 relievers to the mound over the course of the season. Their bullpen pitchers have come in 40 times in high leverage situations and on 24 occasions with runners on base. With 37 save situations, the Diamondbacks have accrued 22 holds in addition to 5 blown saves. Arizona has called on relievers to enter the contest in 14 save chances and they have come away with 9 saves. Arizona relievers have an inherited score percentage of 25.0% of 32 inherited base runners.

The Arizona Diamondbacks have gotten 17 double plays and own a fielding percentage of .988 (9th in the majors). The Diamondbacks have recorded 221 assists, 11 errors and have a tally of 667 putouts so far this year. In their 2,001 innings on the field, the Diamondbacks have a defensive efficiency of 70.6% (11th in pro baseball).

During his MLB career, Gallen has given up 874 hits while he has accumulated 1,074 punch outs in 1,032 innings. Gallen (67-53 career win-loss mark) has a 3.58 ERA while allowing 7.6 hits per nine innings. He has conceded a total of 411 earned runs while earning a WHIP of 1.167 and being the owner of a FIP of 3.5. His strikeout to walk ratio is 3.24 and he has gone up against 4,252 hitters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Arizona (+110)

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