San Diego Padres vs Chicago Cubs Prediction, 6/29/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Chicago Cubs

Date: Monday, June 29, 2026

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: San Diego (+106) Chicago (-128)

The San Diego Padres (43-38) are on their way to Wrigley Field on Monday where they will compete against the Chicago Cubs (45-38). The line on this contest has San Diego at +106 and Chicago is opening at -128. The betting total is set at 8. The expected starting pitchers will be German Marquez and Shota Imanaga.

San Diego owns a slugging percentage of .366 and have been rung up 680 times, while being walked on 271 occasions. They have amassed 311 runs batted in in addition to 583 hits so far this season, while their batting average sits at .221. The Padres have accumulated 117 doubles as a team and have smacked 83 balls out of the park. They have accounted for 319 runs and hold an on-base percentage of .297. As a unit, the San Diego Padres are earning 3.9 runs per outing, which has them sitting at 29th in MLB.

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Their strikeout to walk ratio is 2.36 and their pitching staff has a team WHIP of 1.30. Padres pitchers have surrendered 80 home runs and 330 runs (6th in MLB). San Diego has given up 655 hits (8.2 per 9 innings) as well as 312 earned runs. The Padres have compiled a team ERA of 3.91 so far this year (10th in MLB), and the staff has struck out 669 hitters. Their pitching staff has walked 283 hitters and their FIP comes in at 4.02 as a team for the year.

Padres relief pitchers have entered the game with runners on 82 times and also have had 94 appearances in high leverage situations. The relievers are sitting with 52 holds on the season (7th in MLB). The Padres bullpen have accumulated a save percentage of 73.5% and have entered the game in 88 save situations. They have earned 25 saves over the course of the season and have blown 9 of their 34 chances to save the game. The relievers have inherited 140 runners over the course of the season with 31.4% of those players crossing home plate. The Padres have sent 277 relievers to the mound on the season.

The Padres have turned 70.1% of baseballs in play into outs in their 6,471 innings, which has them ranked 14th in professional baseball. The San Diego Padres have earned 2,157 putouts this year, as well as 725 assists and 27 errors. Their fielding percentage is at .991 which has them sitting 2nd in MLB, and they have turned 71 double plays.

Marquez (71-74 mark in his career) is the owner of a FIP of 4.63 while he has gone up against 5,035 opposing hitters during his time in the majors. He has surrendered 1,206 hits (9.2 hits per nine innings) and has 366 free passes. His ERA is 4.70 (614 earned runs allowed) and he has a WHIP of 1.338. Marquez has taken the mound for 1,175 innings and is sitting with 1,088 K's so far in his pro baseball career.

The Chicago Cubs have accounted for an on-base percentage of .336 and a batting average of .242 for the season. They have struck out on 701 occasions (13th in baseball) and have tallied 685 hits. Chicago has 99 home runs so far this year as well as 381 RBIs. The Cubs hold a team slugging percentage of .404 and they are recording 4.93 runs per contest (6th in the league). They have tallied 133 doubles, while taking a walk 367 times and racking up 409 runs.

The Chicago pitching staff have allowed 370 runs on the year while holding a team ERA of 4.27 (350 earned runs yielded). They have given up 126 homers and they concede 4.52 runs per 9 innings (14th in MLB). The Cubs have a team WHIP of 1.245 and are the owners of a FIP of 4.72 as a staff on the campaign. Their strikeout to walk ratio is 7.90 (650 strikeouts vs 257 walks). They rank 14th in the league as a staff in total hits surrendered with 661.

Chicago relievers have an inherited score percentage of 30.4% out of their 115 inherited base runners. Their bullpen pitchers have stepped onto the hill 78 times in high leverage situations and on 81 occasions with base runners. With 58 save situations, the Cubs have tallied 28 holds and 14 blown saves. They sit at 28th in the league with a save rate of 46.2%, and they have sent 268 relief pitchers to the hill on the campaign.

In their 6,636 innings on the diamond, the Cubs have a defensive efficiency of 72.6% (2nd in professional baseball). The Chicago Cubs have turned 57 double plays and hold a fielding percentage of .989 (5th in baseball). The Cubs have recorded 764 assists, 33 errors and have 2,212 putouts on the campaign.

Imanaga (29-17 career record) has a 3.53 earned run average and has conceded 7.5 hits per 9 innings. His strikeout to walk ratio is 4.92 and he has gone up against 1,630 opposing hitters in his pro baseball career. He has conceded 161 ER's while earning a WHIP of 1.017 and having a FIP of 3.5. So far in his career, Imanaga has conceded 340 hits and he has 379 strikeouts in 410 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (-128)

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