San Diego Padres vs Cincinnati Reds Prediction, 9/2/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Cincinnati Reds

Date: Wednesday, September 2, 2026

Location: Great American Ball Park in Cincinnati, OH

TV: Reds.TV

Odds/Point Spread: San Diego (-144) Cincinnati (+120)

The San Diego Padres (73-65) are en route to Great American Ball Park on Wednesday where they will try to defeat the Cincinnati Reds (65-73). The moneyline on this contest has the Padres at -144 and the Reds are priced at +120. The total comes in at 9. The starting pitchers will be Casey Mize and Brandon Williamson.

As a squad, the San Diego Padres are recording 4.3 runs per game, which has them at 22nd in baseball. They are sitting with 588 runs and hold an OBP of .315. The Padres have compiled 200 doubles as a squad and have smacked 150 balls out of the park. They have tallied 566 runs batted in and 1,082 base knocks on the campaign, and their team batting average is .238. San Diego has a slugging % of .386 and have been called out on strikes 1,119 times, while taking a walk on 477 occasions.

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They have a strikeout to walk ratio of 2.38 and their pitching staff holds a collective WHIP of 1.29. Padres pitchers have allowed 152 home runs and 573 total runs (9th in the league). San Diego has given up 1,107 hits (8.2 per 9 innings) and 531 earned runs. The Padres hold a team ERA of 3.91 for the season (9th in baseball), and the staff has rung up 1,117 hitters. They have walked 469 opposing batters and their FIP is 4.17 as a unit for the season.

Padres relief pitchers have come into the game with opponents on base 131 times in addition to having 153 appearances in high leverage situations. The relievers have a total of 85 holds for the year (8th in the league). The Padres bullpen have earned a save rate of 69.0% and have entered the game in 146 save situations. They have 40 saves over the course of the season and have blown 18 out of their 58 chances to get a save. The relief pitchers have inherited 213 base runners for the year with 31.9% of them crossing home plate. The Padres have dispatched 462 relief pitchers to the hill so far this season.

The San Diego Padres have notched a total of 3,667 putouts on the campaign, as well as 1,220 assists and 58 errors. Their fielding percentage is at .988 which is 5th in MLB, and have 112 double plays. The Padres have transformed 70.6% of balls in play into outs out of 11,001 innings, which has them sitting 10th in pro baseball.

Mize (24-27 career win-loss mark) has a FIP of 4.23 while going up against 1,974 hitters in the major leagues. He has surrendered 473 base knocks (9.2 hits per 9 innings) and has 129 free passes. His ERA is 4.30 (221 earned runs allowed) and his WHIP is 1.300. Mize has thrown 463 frames and has accumulated 376 strikeouts in his career.

The Reds have a team slugging % of .395 and they are scoring 4.13 runs per contest (23rd in the league). They have 194 doubles, while walking 493 times and notching 570 runs. Cincinnati has accumulated 183 HRs this year as well as 546 runs batted in. They have been rung up on 1,315 instances (2nd in the league) and are sitting with 1,046 base hits. The Cincinnati Reds have compiled a team OBP of .307 and a team batting average of .228 on the season.

The Reds have a team WHIP of 1.426 and have a FIP of 4.70 as a unit on the season. They have earned a K/BB ratio of 8.20 (1,109 strikeouts against 559 walks). They sit at 25th in baseball as a pitching staff in total hits given up with 1,187. They have conceded 177 home runs and they concede 5.02 runs per 9 innings (26th in the league). The Cincinnati pitching staff have surrendered 683 runs this year while having a team ERA of 4.67 (635 earned runs relinquished).

Cincinnati relievers have an inherited score rate of 27.8% out of 216 inherited base runners. Their bullpen pitchers have stepped onto the hill 167 times in high leverage situations in addition to 148 occasions with runners on. Sitting with 135 save situations, the Reds have earned 75 holds and 21 blown saves. They are ranked 15th in the league holding a save rate of 63.2%, and they have sent 485 relievers to the hill so far this year.

The Cincinnati Reds have turned 93 double plays and have a fielding percentage of .984 (19th in the majors). The Reds have recorded 1,107 assists, 77 errors and have a tally of 3,672 putouts this season. In their 11,016 innings on the field, the Reds have earned a efficiency on defense of 69.6% (18th in professional baseball).

During his career, Williamson has allowed 147 base knocks while earning 129 strikeouts in 159 innings. Williamson (7-8 career record) has earned a 4.70 earned run average and has allowed 8.3 hits per nine innings. He has allowed a total of 83 ER's while holding a WHIP of 1.326 and a FIP of 4.6. He has a K/BB ratio of 2.02 and he has faced 678 opposing hitters during his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take San Diego (-144)

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