San Diego Padres vs Colorado Rockies Prediction, 4/21/2026 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Colorado Rockies

Date: Tuesday, April 21, 2026

Location: Coors Field in Denver, CO

TV: Rockies.TV

Odds/Point Spread: San Diego (-152) Colorado (+126)

The Colorado Rockies (9-13) will compete against the San Diego Padres (15-7) at Coors Field on Tuesday. The line on this contest has San Diego at -152 while Colorado is sitting at +126. The betting total is set at 8.5. The starting pitchers are Randy Vasquez and Chase Dollander.

The Padres have hit 44 two-baggers as a unit and have knocked 17 baseballs out of the park. San Diego owns a slugging percentage of .369 and have been called out on strikes 171 times, while drawing a walk on 78 occasions. As a team, the San Diego Padres are putting up 4.4 runs per game, which ranks them 15th in MLB. They have recorded 91 RBI's as well as 168 base knocks for the year, and their team batting average is at .232. They have accumulated 96 runs and have an OBP of .310.

Get all of our MLB Picks Today

The Padres hold a team ERA of 3.36 on the campaign (5th in the league), and their staff has rung up 212 batters. Padres pitchers have conceded 13 long balls in addition to 79 runs (4th in the league). They have walked 76 batters and their FIP comes in at 3.19 as a squad on the season. San Diego has given up 168 hits (7.6 per 9 innings) and 74 earned runs. They have earned a strikeout to walk ratio of 2.79 and their pitching staff has a collective WHIP of 1.23.

The Padres relief pitchers have recorded a save rate of 64.3% and have entered the game in 34 save situations. They have compiled 9 saves on the year and have blown 5 of 14 chances to get a save. The relief pitchers have inherited 37 runners so far this season and 43.2% of those players ended up scoring. Padres relief pitchers have entered the contest with runners on base 21 times and also have had 25 appearances in high leverage situations. The Padres have dispatched 77 relievers to the mound for the season. The bullpen have a total of 18 holds this year (6th in MLB).

The San Diego Padres have a total of 594 putouts on the year, in addition to 184 assists and 6 errors. Their fielding percentage is currently at .992 which is 3rd in professional baseball, and have 19 double plays. The Padres have turned 69.1% of balls hit into play into outs out of 1,782 innings on the field, which ranks them 23rd in MLB.

Vasquez (13-16 career record) has a FIP of 3.91 and he has gone up against 1,257 opposing batters in the major leagues. He has surrendered 294 hits (9.1 hits per 9 innings) with 107 free passes. His earned run average is 3.97 (128 ER's allowed) and his WHIP is 1.381. Vasquez has taken the hill for 290 innings and is sitting with 198 strikeouts during his MLB career.

The Colorado Rockies have tallied a team OBP of .310 as well as a team batting average of .241 for the year. They have been called out on strikes on 216 occasions (2nd in MLB) and have recorded 177 hits. Colorado has knocked in 22 home runs over the course of the season and 86 runs batted in. The Rockies have a team slugging % of .386 and they score 4.05 runs per game (21st in baseball). They have recorded 37 doubles, while getting a free base 65 times as well as scoring 89 runs.

The Rockies hold a team WHIP of 1.388 in addition to having a FIP of 4.59 as a pitching staff for the season. They come in at 27th in the league as a pitching staff in total hits given up with 195. The Colorado pitching staff have yielded 99 runs for the season while holding an ERA of 4.15 (89 earned runs surrendered). They have earned a strikeout to walk ratio of 7.60 (163 strikeouts vs 73 walks). They have conceded 27 long balls and they allow 4.61 runs per 9 innings (17th in baseball).

With 17 save situations, the Rockies have 8 holds and 2 blown saves. Colorado has called on bullpen pitchers to step onto the hill in 9 save chances and they have come away with 7 saves. Colorado bullpen pitchers hold an inherited score percentage of 13.9% out of 36 inherited base runners. Their bullpen pitchers have stepped onto the mound 26 times in high leverage situations and on 23 occasions with runners on. They rank 5th in baseball with a save rate of 77.8%, and they have sent 68 relievers onto the field so far this year.

Out of their 1,740 innings played, the Rockies have a defensive efficiency of 69.3% (21st in baseball). The Colorado Rockies have turned 19 double plays and have earned a fielding percentage of .987 (12th in professional baseball). The Rockies have 186 assists, 10 errors and have a tally of 580 putouts on the season.

During his career, Dollander has surrendered 118 base knocks and he has 105 strikeouts in 117 innings pitched. Dollander (4-13 career win-loss mark) has a 6.00 ERA and has surrendered 9.1 hits per nine innings. He has given up 78 earned runs while earning a WHIP of 1.479 and being the owner of a FIP of 5.9. His strikeout to walk ratio is 1.91 and he has gone up against 521 opposing hitters during his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take San Diego (-152)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.